4 terminated, 3 completed, 1 not yet recruiting, 1 recruiting. 4 Phase 2, 3 Phase 3, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Terminated 2, Completed 1, Not yet recruiting 1 |
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Not applicable | 1 | Terminated 1 |
| Phase 1 | 1 | Completed 1 |
Follow Acute Alcoholic Hepatitis: new trials by email Literature Review of Acute Alcoholic Hepatitis trials Research Report on Acute Alcoholic Hepatitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial miroliverELAP treatment - Acute Liver Failure, Acute Liver Injury, Drug Induced | Phase 1 | Completed | Miromatrix Medical Inc. | 10 | 2024-10-05 | 2026-03-06 |
| MRG-001 in Patients With Alcoholic Hepatitis MRG-001 - Alcoholic Hepatitis, Acute Alcoholic Hepatitis | Phase 2 | Not yet recruiting | MedRegen LLC | 32 | 2024-09-01 | 2024-03-13 |
| Integrative Epidemiology of Prognosis in Patients With Acute Alcoholic Hepatitis at AP-HP Acute Alcoholic Hepatitis | Recruiting | Assistance Publique - Hôpitaux de Paris | 1400 | 2024-07-19 | 2025-12-03 | |
| Digoxin In Treatment of Alcohol Associated Hepatitis Intravenous digoxin - Acute Alcoholic Hepatitis, Chemical and Drug Induced Liver Injury | Phase 2 | Terminated | Yale University | 23 | 2021-10-08 | 2026-09-29 |
| Randomized, Open-Label, Multicenter, Controlled, Pivotal Study to Assess Safety and Efficacy of ELAD in Subjects w/ AILD ELAD System, Standard of Care (Control) - Acute Alcoholic Hepatitis | Phase 3 | Terminated | Vital Therapies, Inc. | 151 | 2016-01-01 | 2019-01-25 |
| Pharmacokinetic and Pharmacodynamic Study of IDN-6556 in ACLF IDN-6556, Placebo - Acute on Chronic Hepatic Failure, Acute Liver Failure | Phase 2 | Terminated | Conatus Pharmaceuticals Inc. | 23 | 2013-09-01 | 2016-04-11 |
| Efficacy Study of Anakinra, Pentoxifylline, and Zinc Compared to Methylprednisolone in Severe Acute Alcoholic Hepatitis Anakinra, Pentoxifylline, Zinc Sulfate - Acute Alcoholic Hepatitis | Phase 2 / Phase 3 | Completed | Mack Mitchell | 104 | 2013-09-01 | 2021-11-01 |
| Novel Therapies in Moderately Severe Acute Alcoholic Hepatitis Lactobacillus Rhamnosus GG, Placebo for Probiotic - Acute Alcoholic Hepatitis | Not applicable | Terminated | University of Texas Southwestern Medical Center | 45 | 2013-08-01 | 2022-03-02 |
| Assess Safety and Efficacy of ELAD (Extracorporeal Liver Assist System) in Subjects With Alcohol-Induced Liver Failure ELAD treatment, Standard of care (Control) - Acute Alcoholic Hepatitis | Phase 3 | Completed | Vital Therapies, Inc. | 203 | 2013-02-01 | 2019-02-15 |
Hepatitis, Alcoholic (4) · Chemical and Drug Induced Liver Injury (2) · Hepatitis (2) · Liver Failure, Acute (2) · Acute-On-Chronic Liver Failure (1) · Alcohol-Induced Disorders (1) · Fatty Liver, Alcoholic (1) · Fibrosis (1) · Infections (1) · Liver Cirrhosis (1) · Liver Diseases (1) · Liver Diseases, Alcoholic (1) · Liver Failure (1)
Digestive System Diseases (7) · Chemically-Induced Disorders (6) · Liver Diseases (6) · Alcohol-Related Disorders (5) · Substance-Related Disorders (5) · Alcohol-Induced Disorders (4) · Hepatitis (4) · Liver Diseases, Alcoholic (4) · Drug-Related Side Effects and Adverse Reactions (2) · Hepatic Insufficiency (2) · Poisoning (2) · Fatty Liver (1) · Liver Failure (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Standard of Care (2) · 3-(2-(2-tert-butylphenylaminooxalyl)aminopropionylamino)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid (1) · Digoxin (1) · Drugs, Generic (1) · Interleukin 1 Receptor Antagonist Protein (1) · Methylprednisolone (1) · Pentoxifylline (1) · Probiotics (1) · Zinc Sulfate (1)
Vital Therapies, Inc. (2) · Assistance Publique - Hôpitaux de Paris (1) · Conatus Pharmaceuticals Inc. (1) · Mack Mitchell (1) · MedRegen LLC (1) · Miromatrix Medical Inc. (1) · University of Texas Southwestern Medical Center (1) · Yale University (1)
United States (7) · United Kingdom (3) · Spain (2) · Australia (1) · Austria (1) · France (1) · Germany (1) · Ireland (1)
Ali Al-Khafaji, MD (2) · Jan Stange, MD (2) · Julie Thompson, MD (2) · Kalyan R Bhamidimarri, MD (2) · Nikunj Shah, MD (2) · Ram Subramanian, MD (2) · Raza Malik, MD (2) · Simona Rossi, MD (2) · Talal Adhami, MD (2) · Waldo Concepcion, MD (2) · Agustin Albillos, MD (1) · Ahmed M Elsharkawy, MD (1) · Alan Wigg, MD (1) · Alasdair Hay, MD (1) · Alexander Kuo, MD (1)
PMID 31811953, PMID 29171941, PMID 35084335, PMID 35340032, PMID 37011138, PMID 37040544, PMID 37633275
U01AA021893 (2)