35 completed, 3 terminated, 2 unknown. 37 Phase 1, 2 Phase 3, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 37 | Completed 34, Terminated 2, Unknown 1 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy Volunteers RXC007, RXC007 Matching Placebo - Fibrosis, Inflammation | Phase 1 | Completed | Redx Pharma Ltd | 90 | 2021-05-13 | 2023-11-18 |
| Study to Evaluate the Safety, Tolerability and Immunogenicity of a Potential Enteric Fever Vaccine ZH9PA and ZH9, Placebo, ZH9PA - Enteric Fever | Phase 1 | Completed | Prokarium Ltd | 46 | 2019-12-16 | 2025-08-17 |
| A Scintigraphy Study of PT010 in COPD Patients BGF-MDI - Chronic Obstructive Pulmonary Disease | Phase 1 | Completed | AstraZeneca | 18 | 2019-04-04 | 2021-02-12 |
| Group B Streptococcus Vaccine in Healthy Females GBS-NN/NN2 with Alhydrogel® 25, Placebo GBS-NN/NN2 with Alhydrogel® 25, Placebo GBS-NN/NN2 with Alhydrogel® 50 - Group B Strep Infection | Phase 1 | Completed | Minervax ApS | 60 | 2019-01-09 | 2021-02-02 |
| A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers SPR720 for SAD, Placebo for SAD, SPR720 for MAD - Healthy Volunteers | Phase 1 | Completed | Spero Therapeutics | 96 | 2018-12-18 | 2019-10-28 |
| Efficacy and Safety of Remimazolam (CNS7056) Compared to Propofol for Intravenous Anesthesia During Elective Surgery Remimazolam, Propofol - Anesthesia, Intravenous | Phase 3 | Completed | Paion UK Ltd. | 469 | 2018-07-24 | 2020-05-28 |
| BN201 SAD MAD Study in Healthy Subjects Comparison of BN201 treatment with Placebo - Optic Neuritis, Optic; Neuritis, With Demyelination | Phase 1 | Completed | Accure Therapeutics | 48 | 2018-05-27 | 2019-04-10 |
| Study to Investigate the Pharmacokinetics & Safety Following One Application of 3 Different Doses 0.5,0.75,& 1.25 gm,a Transdermal Estradiol Cream (VML-0203), in Comparison to a Single Dose of EstroGel 1.25 gm to Healthy Post-menopausal Women. Estrogel - Menopause | Phase 1 | Unknown | Viramal Limited | 20 | 2018-05-22 | 2022-04-27 |
| A Study of Infacort® Versus Cortef® in Healthy Adult Male and Female Subjects Infacort®, Cortef® - Adrenal Insufficiency | Phase 1 | Completed | Neurocrine UK Limited | 51 | 2018-04-16 | 2026-09-14 |
| A Study of Chronocort® Versus Cortef ® in Healthy Adult Male Subjects Chronocort®, Cortef® - Adrenal Insufficiency | Phase 1 | Completed | Neurocrine UK Limited | 25 | 2018-02-19 | 2026-09-14 |
| Nurofen Ibuprofen Orodispersible Tablet Disintegration Study 200 mg Ibuprofen acid orodispersible tablet - Healthy | Not applicable | Terminated | Reckitt Benckiser Healthcare (UK) Limited | 29 | 2017-12-19 | 2018-09-05 |
| Phase 1 Study to Evaluate DDI, PK, Safety, Tolerability of SPR741 SPR741, Ceftazidime, Piperacillin/tazobactam - Healthy Volunteers | Phase 1 | Completed | Spero Therapeutics | 27 | 2017-11-10 | 2018-01-05 |
| Two-period 21 Day Cross-over Study to Compare the Pharmacokinetics of Tiotropium From Two Inhalers Tiotropium - Healthy | Phase 1 | Completed | Kindeva Drug Delivery | 40 | 2017-07-13 | 2025-12-04 |
| Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral Administration Infacort - Adrenal Insufficiency | Phase 1 | Completed | Neurocrine UK Limited | 19 | 2017-05-22 | 2026-09-14 |
| Ibuprofen Bioavailability Study Test - RB ibuprofen acid orodispersible tablets, Reference - RB Nurofen ibuprofen acid tablets, Comparator - Dolormin ibuprofen lysine tablets - Healthy | Phase 1 | Completed | Reckitt Benckiser Healthcare (UK) Limited | 36 | 2017-04-10 | 2017-10-05 |
| Study to Compare DITEST to Testosterone Undecanoate in Adult Men With Hypogonadism DITEST, Testosterone undecanoate - Male Hypogonadism | Phase 1 | Completed | Neurocrine UK Limited | 25 | 2016-11-03 | 2026-09-14 |
| A Study of SENS 401 in Healthy Subjects SENS-401, Placebo - Inner Ear Disease | Phase 1 | Completed | Simbec Research | 36 | 2016-10-21 | 2019-04-08 |
| Naproxen Sodium (2 x 220 mg) Fasted Comparative Bioavailability Study Test, Reference - Healthy | Phase 1 | Completed | Reckitt Benckiser Healthcare (UK) Limited | 18 | 2016-10-12 | 2019-02-28 |
| Ibuprofen and Pseudoephedrine Comparative Pharmacokinetic Study Test Nurofen Cold and Flu®, Ibuprofen and pseudoephedrine liquid capsules, Comparator 1 Nurofen Cold and Flu®, ibuprofen and pseudoephedrine tablets, Comparator 2 Nurofen Immedia 200 mg Weichkapseln, ibuprofen liquid capsules - Healthy | Phase 1 | Completed | Reckitt Benckiser Healthcare (UK) Limited | 55 | 2016-08-10 | 2017-06-14 |
| Multiple Ascending Dose Study of GMC-252-L-Lys Salt in Healthy Subjects and Type 2 Diabetics GMC-252-L-Lysine Salt, Placebo - Healthy, Type 2 Diabetes Mellitus | Phase 1 | Terminated | Genmedica Therapeutics S.L. | 34 | 2016-04-01 | 2017-10-12 |
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Adrenal Insufficiency (6) · Adrenal Hyperplasia, Congenital (2) · Labyrinth Diseases (2) · Acute Pain (1) · Asthma (1) · Demyelinating Diseases (1) · Diabetes Mellitus, Type 2 (1) · Eunuchism (1) · Fibrosis (1) · Hypersensitivity (1) · Hypogonadism (1) · Idiopathic Pulmonary Fibrosis (1) · Inflammation (1) · Kidney Diseases (1) · Liver Diseases (1)
Hydrocortisone (6) · Ibuprofen (3) · Dexamethasone (2) · (5-fluoro-2-methyl-3-quinolin-2-ylmethylindo-1-yl)acetic acid (1) · Acetaminophen (1) · Aztreonam (1) · Ceftazidime (1) · Clonidine (1) · Estradiol (1) · Granisetron (1) · Influenza Vaccines (1) · Piperacillin, Tazobactam Drug Combination (1) · Propofol (1) · Pseudoephedrine (1) · Radiotherapy (1)
United Kingdom (29) · Germany (1)
Girish Sharma, MBBS (5) · Robert Adams, MBBS (4) · Annelize Koch, MBChB (3) · A Koch (2) · Girish Sharma (2) · Girish Sharma, MD (2) · Salvatore Febbraro, MD (2) · Annelize Koch (1) · Annelize Koch, MBBS (1) · Brian R Walker, BSc MBChB MD (1) · Christopher Bailey, Bsc, PhD (1) · David P. Dearnaley, MD, FRCP, FRCR (1) · Dr Simona Fiore, MD (1) · Ezanul Wahab (1)
PMID 28726169, PMID 29132988, PMID 29667449, PMID 31202508, PMID 31262767, PMID 33807097, PMID 34491803, PMID 34620167
2014 (2), 2017 (2), 2015 (1)