21 completed, 4 recruiting, 3 terminated, 3 unknown. 35 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 35 | Completed 21, Recruiting 4, Terminated 3, Unknown 3, Not yet recruiting 2, Active not recruiting 1, Withdrawn 1 |
| Phase 2 | 8 | Completed 5, Unknown 2, Terminated 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CARE-Melanoma Trial Rehabilitation - Melanoma (Skin Cancer) | Phase 1 | Not yet recruiting | McMaster University | 30 | 2026-01-20 | 2026-01-06 |
| Progesterone and Muscle Protein Synthesis in Premenopausal Women (MP4-MPS) Micronized progesterone (oral capsules), placebo capsule - Healthy Volunteers, Female | Phase 1 | Completed | McMaster University | 20 | 2026-01-01 | 2026-06-17 |
| The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges Adenosine 5'-triphosphate - Chronic Cough (CC), Asthma | Phase 1 | Recruiting | McMaster University | 33 | 2025-08-05 | 2025-08-29 |
| Affect of Duavive on Mood & Anxiety Symptoms Duavive 0.45Mg-20Mg Tablet - Menopause, Depression, Anxiety | Phase 1 | Recruiting | St. Joseph's Healthcare Hamilton | 30 | 2024-07-03 | 2024-12-03 |
| The Pharmacokinetics of Single Dose Oral Tetrahydrocannabinol and Cannabidiol Tetrahydrocannabinol-Cannabidiol Combination - Cannabis, Chronic Kidney Diseases | Phase 1 | Active not recruiting | McMaster University | 24 | 2024-01-11 | 2024-11-20 |
| Effects of Probiotics on Synaptic Plasticity During the Menstrual Cycle Progressive Perfect Probiotic, Placebo - Women's Health, Brain Plasticity | Phase 1 | Unknown | McMaster University | 40 | 2024-01-01 | 2024-01-19 |
| Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control Metformin, Salsalate - Diabetes Mellitus, Type 2, Hyperglycemia | Phase 1 | Withdrawn | McMaster University | 2023-12-01 | 2026-06-12 | |
| Intravesical Mitomycin C After Diagnostic Ureteroscopy for Upper Tract Urothelial Carcinoma Mitomycin C - Urothelial Carcinoma Ureter, Urothelial Cancer of Renal Pelvis | Phase 1 | Not yet recruiting | McMaster University | 40 | 2023-09-01 | 2023-08-07 |
| AMIC Compared With Microfracture for Focal Articular Cartilage Damage of the Hip Autologous matrix-induced chondrogenesis (AMIC) - Hip Arthroscopy, Articular Cartilage Defect | Phase 1 | Recruiting | McMaster University | 40 | 2023-03-13 | 2026-10-07 |
| Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI) Intravenous DNase I - Sepsis, Critical Illness | Phase 1 | Recruiting | McMaster University | 36 | 2023-01-17 | 2026-03-03 |
| Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol Ad5-triCoV/Mac, ChAd-triCoV/Mac - COVID-19, SARS-CoV2 Infection | Phase 1 | Completed | McMaster University | 36 | 2022-01-03 | 2025-07-17 |
| Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women Estring Vaginal Ring, RepHresh Pro-B - HIV-1-infection, Bacterial Vaginoses | Phase 1 | Completed | McMaster University | 50 | 2019-11-04 | 2021-12-17 |
| Phase 1 Clinical Trial of the Safety and Immunogenicity of an Adenovirus-based TB Vaccine Administered by Aerosol Ad5Ag85A - Tuberculosis | Phase 1 | Completed | McMaster University | 36 | 2017-09-05 | 2021-11-01 |
| Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free) Benzodiazepine - limited use strategy, Benzodiazepine - Ad libitum strategy - Post-operative Delirium | Phase 1 | Completed | McMaster University | 480 | 2017-04-01 | 2018-10-16 |
| Effectiveness of a Medication Wallet Card Medication Wallet Card, Reminder Card - Comorbidity, Medication Therapy Management | Phase 1 | Completed | McMaster University | 100 | 2016-07-01 | 2021-09-10 |
| Community Health Assessment Program in the Philippines Community Health Assessment Program Philippines (CHAP-P) - Diabetes | Phase 1 / Phase 2 | Unknown | McMaster University | 45 | 2015-11-01 | 2015-06-24 |
| Early In-bed Cycling in Critically Ill Children In-bed cycling, Usual Care - Critical Illness | Phase 1 / Phase 2 | Completed | McMaster University | 30 | 2015-09-01 | 2018-08-20 |
| Extended Low-Molecular Weight Heparin VTE Prophylaxis in Thoracic Surgery LMWH: Dalteparin, Placebo - Venous Thromboembolism, Lung Neoplasms | Phase 1 / Phase 2 | Completed | McMaster University | 102 | 2015-09-01 | 2018-09-18 |
| The Efficacy of Denosumab in Active Crohn's Disease Denosumab - Crohn Disease | Phase 1 / Phase 2 | Completed | University of Manitoba | 2 | 2015-02-01 | 2018-10-15 |
| Randomized Controlled Feasibility Trial of the Fearon Algorithm to Improve Management of Unstable Warfarin Warfarin adjustment using the Fearon algorithm, Warfarin adjustment using standard dosing - Hypoprothrombinemia | Phase 1 / Phase 2 | Terminated | McMaster University | 42 | 2014-11-01 | 2018-04-06 |
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Adenoviridae Infections (3) · Critical Illness (3) · Asthma (2) · Tuberculosis (2) · Anxiety Disorders (1) · Autistic Disorder (1) · Brain Injuries (1) · Breast Neoplasms (1) · Bronchial Diseases (1) · Bronchitis (1) · COVID-19 (1) · Cerebral Palsy (1) · Chronic Cough (1) · Crohn Disease (1) · Deglutition Disorders (1)
Adenosine Triphosphate (1) · Alprazolam (1) · Dalteparin (1) · Denosumab (1) · Diazepam (1) · Estradiol (1) · Lorazepam (1) · Metformin (1) · Mitomycin (1) · PUR003 (1) · Progesterone (1) · Rehabilitation (1) · Resistance Training (1) · Tissue Plasminogen Activator (1) · maltodextrin (1)
Canada (30) · United States (1)
Fiona M Smaill, MD (2) · Karen Choong, MB, BCh, MSc (2) · Ainsley Moore, MD (1) · Alison Shea, MD (1) · Audrey Hicks, PhD (1) · Catherine Amlie-Lefond, MD (1) · Charles N Bernstein, MD (1) · Fiona M Smaill, MB,ChB (1) · Jenny Ploeg, RN, PhD (1) · Levine Mark, MD (1) · Lori-Ann Linkins, MD, MSc (1) · Michael Walsh, MD, PhD (1) · Parameswaran Nair, MD, PhD (1) · Peter McLean, PhD (1) · Pierre P. Major, MD (1)
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