38 completed. 38 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 38 | Completed 38 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty Morphine, Vancomycin - Primary Total Knee Arthroplasty, Intraosseous Morphine Injection | Phase 2 | Completed | Carilion Clinic | 100 | 2024-12-01 | 2025-09-10 |
| Abbreviated Protocol for Two-Stage Exchange VT-X7 Treatment System with Tobramycin Sulfate, Standard of Care, Two-stage exchange arthroplasty - Prosthetic Joint Infection | Phase 2 | Completed | Osteal Therapeutics, Inc. | 76 | 2021-11-01 | 2026-10-15 |
| PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN Imipenem/Cilastatin/Relebactam, Cefepime, Meropenem - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 2 | Completed | M.D. Anderson Cancer Center | 100 | 2021-09-14 | 2026-04-06 |
| VE303 for Treatment of Hepatic Encephalopathy (HE) Placebo, VE303, oral vancomycin - Cirrhosis, Hepatic Encephalopathy | Phase 2 | Completed | Patricia Bloom | 19 | 2021-08-06 | 2025-02-07 |
| DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia Cefazolin, Dalbavancin, Daptomycin - Staphylococcal Bacteraemia | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 200 | 2021-04-22 | 2024-12-10 |
| ACX-362E [Ibezapolstat] for Oral Treatment of Clostridioides Difficile Infection Ibezapolstat, Vancomycin - Clostridium Difficile Infection | Phase 2 | Completed | Acurx Pharmaceuticals Inc. | 53 | 2020-03-06 | 2025-01-17 |
| Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer VE800, Nivolumab, Vancomycin Oral Capsule - Metastatic Cancer, Melanoma | Phase 1 / Phase 2 | Completed | Vedanta Biosciences, Inc. | 56 | 2020-01-23 | 2025-10-27 |
| Suprafascial Vancomycin Powder for Prevention of Surgical Site Infections After Instrumented Posterior Spinal Fusion Vancomycin - Surgical Site Infection | Phase 2 | Completed | Insel Gruppe AG, University Hospital Bern | 450 | 2019-10-15 | 2026-08-05 |
| MTT for Children With Both Pitt Hopkins Syndrome and Gastrointestinal Disorders vancomycin, magnesium citrate, microbiota, placebo vancomycin, real magnesium citrate, placebo microbiota - Pitt Hopkins Syndrome | Phase 2 | Completed | Arizona State University | 6 | 2019-09-30 | 2024-08-26 |
| TNP-2092 to Treat Acute Bacterial Skin and Skin Structure Infection TNP-2092, Vancomycin - Skin and Subcutaneous Tissue Bacterial Infections, Gram-Positive Bacterial Infections | Phase 2 | Completed | TenNor Therapeutics Limited | 120 | 2019-04-20 | 2023-12-01 |
| Safety and Efficacy in Patients Treated for Hip or Knee PJI With Vancomycin and Tobramycin Joint Irrigation vancomycin hydrochloride and tobramycin sulfate - Prosthetic Joint Infection | Phase 2 | Completed | Osteal Therapeutics, Inc. | 15 | 2018-10-26 | 2022-01-11 |
| Topical Antibiotics in Chronic Rhinosinusitis Mupirocin, Tobramycin, Levofloxacin - Chronic Rhinosinusitis (Diagnosis) | Phase 1 / Phase 2 | Completed | Mayo Clinic | 19 | 2018-09-26 | 2022-04-20 |
| Regional Prophylactic Vancomycin With Restricted Tourniquet Time in Primary Total Knee Replacement Vancomycin - Arthropathy of Knee Joint | Phase 2 / Phase 3 | Completed | Mayo Clinic | 24 | 2018-09-24 | 2020-01-27 |
| Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease Vancomycin, Neomycin, Ciprofloxacin - Crohn Disease | Phase 2 | Completed | Children's Hospital of Philadelphia | 10 | 2018-07-12 | 2022-02-09 |
| Vancomycin for C Difficile NAAT+/EIA- Hematology Oncology Patients Vancomycin Oral Capsule, Placebo Oral Capsule - Clostridium Difficile Infection, Hematologic Diseases | Phase 2 | Completed | Medical College of Wisconsin | 9 | 2018-06-01 | 2026-04-15 |
| Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection Vancomycin, Placebo - Recurrent Clostridium Difficile Infection, Clostridium Difficile Infection | Phase 2 | Completed | University of Wisconsin, Madison | 79 | 2018-05-21 | 2025-05-25 |
| The Effect of an Antibiotic on the Production of Uremic Toxins by the Gut Microbiome Vancomycin, Placebo - End Stage Renal Disease | Phase 2 | Completed | NYU Langone Health | 15 | 2017-11-27 | 2021-03-26 |
| Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease Fluconazole, Vancomycin, Neomycin - Crohn's Disease | Phase 2 | Completed | University of Pennsylvania | 8 | 2016-08-01 | 2024-02-06 |
| Fecal Microbiota Transplantation for Severe Clostridium Difficile Infection Single-infusion FMT, Vancomycin (before randomization), multiple-infusion FMT - Clostridium Difficile, Pseudomembranous Colitis | Phase 2 | Completed | Catholic University of the Sacred Heart | 58 | 2016-03-01 | 2018-02-09 |
| Transplantation of Cultured Gut Microflora to Repeat Antibiotic-induced Diarrhea Due to Clostridium Difficile Cultured human intestinal microbiota, Vancomycin, Metronidazole - Clostridium Difficile | Phase 2 | Completed | Per Hellström | 60 | 2014-10-01 | 2019-01-09 |
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Clostridium Infections (8) · Enterocolitis, Pseudomembranous (4) · Gram-Positive Bacterial Infections (4) · Abscess (2) · Bacteremia (2) · Burns (2) · Cellulitis (2) · Crohn Disease (2) · Staphylococcal Infections (2) · Ulcer (2) · Wound Infection (2) · Autism Spectrum Disorder (1) · Bacterial Infections (1) · Colorectal Neoplasms (1) · Diarrhea (1)
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (3) · Cumberland Pharmaceuticals (3) · Mayo Clinic (3) · Arizona State University (2) · Catholic University of the Sacred Heart (2) · Osteal Therapeutics, Inc. (2) · Actelion (1) · Acurx Pharmaceuticals Inc. (1) · Carilion Clinic (1) · Children's Hospital of Philadelphia (1) · Duke University (1) · Insel Gruppe AG, University Hospital Bern (1) · M.D. Anderson Cancer Center (1) · Medical College of Wisconsin (1) · Melinta Therapeutics, Inc. (1)
United States (32) · Canada (5) · Italy (2) · Sweden (2) · United Kingdom (2) · Germany (1) · Russia (1) · South Korea (1) · Spain (1) · Switzerland (1)
G. Ralph Corey, MD (3) · Bryan Springer, MD (2) · Lindsey Albenberg, DO (2) · Alistair Wheeler, MD (1) · Garret W Choby, MD (1) · Issam I Raad (1) · Jae-Joon Yim, MD (1) · James B Adams, PhD (1) · James D Lewis, MD, MSCE (1) · Jerome Lowenstein, MD (1) · Jonathan Krakoff, M.D. (1) · Joseph T Moskal, MD (1) · Judy Wang, MD (1) · Mark J Spangehl (1)
PMID 10440607, PMID 11171619, PMID 18662172, PMID 21871249, PMID 22908174, PMID 23323867, PMID 24884578, PMID 25348519, PMID 25534724, PMID 25534727, PMID 26248357, PMID 26348734, PMID 26433782, PMID 26679243, PMID 27432604, PMID 27707993, PMID 27943501, PMID 28122648, PMID 28461207, PMID 29718329, PMID 29851107, PMID 30264119, PMID 30967657, PMID 32050447, PMID 32235930, PMID 33029899, PMID 33087514, PMID 35091036, PMID 35134880, PMID 35578360, PMID 38604274, PMID 39456544, PMID 39969428, PMID 40516571, PMID 40601321, PMID 40802264, PMID 40993807, PMID 41999282, PMID 9712236
2019 (1), 5UM1AI104681-12 (1), K23DK109136 (1)