49 completed, 13 terminated, 8 recruiting, 7 unknown. 85 Phase 3, 12 Phase 2.
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin Vancomycin (POC) - Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium | Phase 2 / Phase 3 | Withdrawn | University of Maryland, Baltimore | 2027-01-01 | 2026-07-29 | |
| Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures Vancomycin (VAN) treatment, Standard Open Fracture Care - Open Fracture | Phase 3 | Not yet recruiting | Atlantic Health System | 100 | 2026-06-10 | 2026-06-22 |
| Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis Bisphosphonates Combined with Vancomycin, Vancomycin - Osteomyelitis (Refractory) | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 280 | 2026-05-01 | 2026-02-27 |
| Vancomycin Taper to Prevent Recurrent Clostridioides Difficile Fidaxomicin, Vancomycin capsule - Clostridia Difficile Colitis | Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 500 | 2026-04-24 | 2026-09-23 |
| Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients Vancomycin 125mg, Placebo - Clostridium Difficile Infection, Vancomycin Resistant Enterococci Infection | Phase 2 / Phase 3 | Recruiting | Riverside University Health System Medical Center | 176 | 2024-10-21 | 2025-11-10 |
| Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid, IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline - Staphylococcus Aureus Bacteremia | Phase 3 | Unknown | Clinical Research Centre, Malaysia | 290 | 2024-06-28 | 2024-07-05 |
| Infection Prophylaxis in Total Joint Replacement Chlorhexidine Gluconate, Vancomycin Hydrochloride, Povidone-Iodine - Periprosthetic Joint Infection | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 21006 | 2024-05-07 | 2026-05-22 |
| Intramedullary Calcium Sulfate Antibiotic Depot Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail - Open tíbia Fracture, Osteomyelitis Tibia | Phase 3 | Recruiting | Wake Forest University Health Sciences | 242 | 2024-04-08 | 2026-10-14 |
| Efficacy of Intrawound Vancomycin in Spine Surgery vancomycin, Standard surgical closure - Surgical Site Infection (SSI), Spine Diseases | Phase 3 | Completed | Ain Shams University | 416 | 2023-12-02 | 2026-10-15 |
| Fecal Microbiota Transplantation in Clostridioides Difficile Infection First Episode and First Recurrence oral capsulized Fecal Microbiota Transplantation, Vancomycin or Fidaxomicin - Clostridioides Difficile Infection | Phase 3 | Recruiting | Benoit Guery | 100 | 2023-03-15 | 2026-07-10 |
| Intracameral Antibiotic Safety Study Vancomycin, Moxifloxacin, Placebo - Intracameral Antibiotics, Cataract Surgery | Phase 3 | Suspended | Panhandle Eye Group, LLP | 500 | 2023-01-01 | 2022-04-27 |
| The Effect of Intrawound Vancomycin Powder on Surgical Site Infection in Inguinal Lymph Node Dissection Vancomycin - Postoperative Complications | Phase 2 / Phase 3 | Recruiting | Women and Infants Hospital of Rhode Island | 30 | 2022-10-25 | 2023-12-05 |
| Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection Oral Vancomycin, Placebo - Clostridioides Difficile Infection | Phase 3 | Completed | Julia Orígüen | 24 | 2022-08-02 | 2024-12-12 |
| Prevention of C.Difficile Infections With Oral Vancomycine in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant Vancomycin, Placebo - Clostridium Difficile Infections, Stem Cell Transplant Complications | Phase 3 | Unknown | Assistance Publique - Hôpitaux de Paris | 336 | 2022-03-01 | 2022-02-25 |
| Safety, Tolerability and the Pharmacokinetics of Ridinilazole in Adolescent Subjects Ridinilazole, Vancomycin - Clostridioides Difficile Infection | Phase 3 | Terminated | Summit Therapeutics | 2 | 2021-05-19 | 2023-08-21 |
| Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT 2 Standard of care, Vancomycin and Tobramycin - Post Operative Surgical Site Infection | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 600 | 2021-05-07 | 2026-07-22 |
| Local Antibiotics for Breast Implants Gentamicin, Cefazolin and Vancomycin, Placebo - Implant Complication, Implant Infection | Phase 3 | Active not recruiting | Mikkel Herly | 1003 | 2021-01-27 | 2026-09-29 |
| Fecal Microbiota Transplantation for Primary Clostridium Difficile Diarrhea Fecal Microbiota Transplantation, Vancomycin, Fecal Microbiota Transplantation Placebo - Clostridium Difficile | Phase 3 | Withdrawn | Memorial University of Newfoundland | 2020-12-01 | 2022-04-29 | |
| Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection Vancomycin, Placebos - Clostridium Difficile Infection | Phase 3 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 263 | 2020-11-19 | 2025-12-10 |
| Intra-wound Vancomycin Powder for Prevention of Surgical Site Infection Following Spinal Surgery Vancomycin - Infection | Phase 3 | Recruiting | Rabin Medical Center | 363 | 2020-05-31 | 2024-11-27 |
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Clostridium Infections (22) · Cellulitis (12) · Infections (10) · Bacterial Infections (9) · Diarrhea (8) · Staphylococcal Infections (8) · Surgical Wound Infection (8) · Skin Diseases, Bacterial (7) · Soft Tissue Infections (7) · Staphylococcal Skin Infections (7) · Abscess (6) · Wound Infection (6) · Bacteremia (5) · Skin Diseases, Infectious (5) · Fever (3)
Cumberland Pharmaceuticals (5) · Pfizer (5) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Melinta Therapeutics, Inc. (4) · Actelion (3) · Basilea Pharmaceutica (3) · Durata Therapeutics Inc., an affiliate of Allergan plc (2) · Forest Laboratories (2) · Mayo Clinic (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · Motif Bio (2) · Novartis Pharmaceuticals (2) · Optimer Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · Rabin Medical Center (2) · Summit Therapeutics (2)
United States (40) · Canada (13) · Germany (11) · Poland (11) · Spain (11) · Argentina (10) · Israel (10) · Romania (10) · Russia (9) · Brazil (8) · Chile (8) · Italy (8) · Ukraine (8) · Bulgaria (7) · Belgium (6)
G. Ralph Corey, MD (6) · Anne Claire Marrast, MD (2) · David Melnick, MSD (2) · Lori Styles, MD (2) · Michael Dunne, MD (2) · Achim J Kaasch, MD (1) · Adam Bressler, MD (1) · Alena Jamdourek, MD (1) · Andreas M Petersen, MD PhD (1) · Anthony R Carlini, MS (1)
PMID 30597021, PMID 30716446, PMID 34741280, PMID 34922058, PMID 18444791, PMID 19095213, PMID 20695801, PMID 21115456, PMID 22416054, PMID 22752857, PMID 22752865, PMID 23715579, PMID 24599770, PMID 24708675, PMID 24897082, PMID 27370913, PMID 27585969, PMID 27718118, PMID 28630189, PMID 29358292, PMID 29454592, PMID 29680101, PMID 29783024, PMID 30349845, PMID 30709665, PMID 32747931, PMID 34905144, PMID 18225981, PMID 18702902, PMID 19036671, PMID 19128645, PMID 19133801, PMID 21115454, PMID 21115455, PMID 21288078, PMID 22311838, PMID 22321770, PMID 22752860, PMID 22752862, PMID 22980682, PMID 23054338, PMID 23776108, PMID 24119597, PMID 24897083, PMID 25294250, PMID 25832968, PMID 25977146, PMID 26363164, PMID 26452342, PMID 27182626
2014 (2), 2009 (1), 2015 (1), 2018 (1)