38 completed, 19 terminated, 14 recruiting, 12 unknown. 96 Phase 2, 12 Phase 3, 10 Phase 1.
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin Vancomycin (POC) - Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium | Phase 2 / Phase 3 | Withdrawn | University of Maryland, Baltimore | 2027-01-01 | 2026-07-29 | |
| A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics - Prosthetic Joint Infection (PJI) | Phase 2 | Recruiting | TenNor Therapeutics (Zhongshan) Limited | 40 | 2026-10-21 | 2026-10-28 |
| Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis Oral Vancomycin - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Tampere University Hospital | 140 | 2026-10-01 | 2026-09-10 |
| A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID - ADHD, ADHD - Attention Deficit Disorder With Hyperactivity | Phase 2 | Not yet recruiting | University of Calgary | 64 | 2026-08-31 | 2026-09-10 |
| Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study) MGT-006, Vancomycin hydrochloride, Amoxicillin hydrate/ Fosfomycin calcium hydrate/ Metronidazole - Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate | Phase 1 / Phase 2 | Recruiting | Metagen Therapeutics, Inc. | 54 | 2026-07-09 | 2026-11-03 |
| Ceftazidime Safety and Efficacy in the Prevention of Surgical Site Infections Topical ceftazidime and vancomycin - Thoracolumbar Spinal Fusion | Phase 2 | Enrolling by invitation | University of Utah | 80 | 2026-07-07 | 2026-11-12 |
| Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Placebo (blinded), Vancomycin (blinded), Vancomycin (open-label extension) - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | McMaster University | 14 | 2026-06-17 | 2026-10-09 |
| Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions Vancomycin (IV) - Healthy Volunteer, Hypersensitivity Reactions | Phase 1 / Phase 2 | Active not recruiting | Johns Hopkins University | 25 | 2026-05-21 | 2026-10-27 |
| Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mg, Inulin/Inulin C13 - IBD, Crohn Disease | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 45 | 2026-01-02 | 2026-03-12 |
| Topical Vancomycin for Infection Prophylaxis in TJA Vancomycin Powder - Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis | Phase 2 | Not yet recruiting | Alberta Hip and Knee Clinic | 100 | 2025-12-30 | 2024-07-31 |
| Maternal Probiotic Intervention to Improve Gut Health-Trial II-Pakistan Oral Vancomycin, VE818, Placebo - Environmental Enteric Dysfunction (EED), Stunting | Phase 2 | Active not recruiting | Aga Khan University | 144 | 2025-08-30 | 2026-11-05 |
| Evaluation of Microbiota Transplant Therapy in Patients With Alopecia Areata Vancomycin, Neomycin and MTT capsules, Placebo capsules - Alopecia Areata, Alopecia Totalis | Phase 2 | Recruiting | University of Minnesota | 40 | 2025-08-21 | 2026-06-26 |
| Maternal Probiotic Intervention to Improve Gut Health - Trial II - Burkina Faso (MPIGH-II) VE818, Placebo, Oral Vancomycin - Environmental Enteric Dysfunction (EED) | Phase 2 | Recruiting | University Ghent | 144 | 2025-07-30 | 2025-11-17 |
| Fecal Microbiota Transfer in Liver Cancer to Overcome Resistance to Atezolizumab/Bevacizumab (FLORA) Fecal microbiota transfer, Vancomycin Oral Capsule, Atezolizumab + Bevacizumab - Immunotherapy, HCC - Hepatocellular Carcinoma | Phase 2 | Recruiting | Michael Dill | 48 | 2025-07-16 | 2025-08-06 |
| Maternal Probiotic Intervention to Improve Gut Health - Trial II - Bangladesh VE818, Placebo, Oral Vancomycin - Environmental Enteric Dysfunction | Phase 2 | Enrolling by invitation | International Centre for Diarrhoeal Disease Research, Bangladesh | 144 | 2025-04-20 | 2025-12-10 |
| A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV) - Periprosthetic Joint Infection (PJI) | Phase 1 / Phase 2 | Recruiting | TenNor Therapeutics Inc. | 33 | 2025-04-03 | 2026-10-19 |
| Effectiveness of Adding Morphine to Intraosseous Vancomycin for Pain Control in Total Knee Arthroplasty Morphine, Vancomycin - Primary Total Knee Arthroplasty, Intraosseous Morphine Injection | Phase 2 | Completed | Carilion Clinic | 100 | 2024-12-01 | 2025-09-10 |
| Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients Vancomycin 125mg, Placebo - Clostridium Difficile Infection, Vancomycin Resistant Enterococci Infection | Phase 2 / Phase 3 | Recruiting | Riverside University Health System Medical Center | 176 | 2024-10-21 | 2025-11-10 |
| Microbiota Transplant Therapy for Children With Both Autism Spectrum Disorder and Gastrointestinal Disorders MTP-101P, Vancomycin, Miralax - Autism Spectrum Disorder, Gastro-Intestinal Disorder | Phase 2 | Unknown | Gut-Brain-Axis Therapeutics Inc. | 60 | 2024-08-20 | 2024-09-25 |
Showing 20 of 96. Sign in to see all of them.
Clostridium Infections (14) · Bacteremia (6) · Colitis, Ulcerative (5) · Gram-Positive Bacterial Infections (5) · Autism Spectrum Disorder (4) · Cholangitis, Sclerosing (4) · Diarrhea (4) · Enterocolitis, Pseudomembranous (4) · Carcinoma, Hepatocellular (3) · Colorectal Neoplasms (3) · Crohn Disease (3) · Digestive System Diseases (3) · Staphylococcal Infections (3) · Surgical Wound Infection (3) · Wound Infection (3)
Arizona State University (4) · Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (4) · Cumberland Pharmaceuticals (3) · Mayo Clinic (3) · Actelion (2) · Catholic University of the Sacred Heart (2) · Gut-Brain-Axis Therapeutics Inc. (2) · M.D. Anderson Cancer Center (2) · National Cancer Institute (NCI) (2) · Osteal Therapeutics, Inc. (2) · University of Minnesota (2) · University of Wisconsin, Madison (2) · Vedanta Biosciences, Inc. (2) · Acurx Pharmaceuticals Inc. (1) · Aga Khan University (1)
United States (59) · Canada (11) · Italy (6) · Spain (5) · United Kingdom (5) · France (4) · China (3) · Germany (3) · Sweden (3) · Switzerland (3) · Czechia (2) · Hungary (2) · Poland (2) · South Korea (2) · Ukraine (2)
G. Ralph Corey, MD (3) · James B Adams, PhD (3) · Bryan Springer, MD (2) · Lindsey Albenberg, DO (2) · Tim F Greten, M.D. (2) · Abbas Khani-Hanjani, MD (1) · Alain Vonlaufen, MD (1) · Alexander Khoruts, MD (1) · Alistair Wheeler, MD (1) · Asad Ali Syed, MPH (1) · Brian Karamian, MD (1) · Carl Lachat, M.Eng., Ph.D. (1)
PMID 10440607, PMID 11171619, PMID 18662172, PMID 21871249, PMID 22908174, PMID 23323867, PMID 24884578, PMID 24943129, PMID 25348519, PMID 25534724, PMID 25534727, PMID 26248357, PMID 26348734, PMID 26433782, PMID 26679243, PMID 27432604, PMID 27682068, PMID 27707993, PMID 27943501, PMID 28011612, PMID 28122648, PMID 28461207, PMID 28760801, PMID 29038277, PMID 29718329, PMID 29851107, PMID 29859132, PMID 30264119, PMID 30967657, PMID 32050447, PMID 32235930, PMID 33029899, PMID 33087514, PMID 33463542, PMID 34843669, PMID 35091036, PMID 35134880, PMID 35578360, PMID 38604274, PMID 39456544, PMID 39969428, PMID 40487852, PMID 40516571, PMID 40601321, PMID 40802264, PMID 40930564, PMID 40993807, PMID 41342324, PMID 41513411, PMID 41705840
2015 (1), 2019 (1), 2025 (1), 5UM1AI104681-12 (1), K23DK109136 (1), P50CA221707 (1), R21AI182531 (1), U01AI125053 (1)