18 completed, 9 recruiting, 5 unknown, 2 active not recruiting. 39 Phase 1, 10 Phase 2.
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease Fecal Microbiota Transplant - Parkinson Disease | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-07-01 | 2026-10-09 |
| Safety, Dosage, and Microbiome Engraftment Study of MGT-006 for Ulcerative Colitis (ROOT Study) MGT-006, Vancomycin hydrochloride, Amoxicillin hydrate/ Fosfomycin calcium hydrate/ Metronidazole - Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate | Phase 1 / Phase 2 | Recruiting | Metagen Therapeutics, Inc. | 54 | 2026-07-09 | 2026-11-03 |
| Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas Vancomycin 125mg, Radiation Therapy, CAR-T - Large B Cell Lymphoma, Non Hodgkin Lymphoma (NHL) | Phase 1 | Recruiting | Abramson Cancer Center at Penn Medicine | 14 | 2026-05-29 | 2026-07-01 |
| Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions Vancomycin (IV) - Healthy Volunteer, Hypersensitivity Reactions | Phase 1 / Phase 2 | Active not recruiting | Johns Hopkins University | 25 | 2026-05-21 | 2026-10-27 |
| Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure MTP-101-C encapsulated Microbiota, Vancomycin, Neomycin - Chronic Heart Failure | Phase 1 | Recruiting | Melana Yuzefpolskaya, MD | 40 | 2025-10-20 | 2026-10-08 |
| A Phase 1/2 Study to Evaluate the Safety, PK and Efficacy of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection (IA), Vancomycin Hydrochloride for Injection (IV) - Periprosthetic Joint Infection (PJI) | Phase 1 / Phase 2 | Recruiting | TenNor Therapeutics Inc. | 33 | 2025-04-03 | 2026-10-19 |
| Vancomycin Dose Optimization in Obesity Vancomycin (IV) - Pharmacokinetics and Pharmacodynamics | Phase 1 | Completed | University of Michigan | 35 | 2025-04-01 | 2026-05-22 |
| A Phase 1b Trial to Evaluate the Safety of MB310 in Patients With Active, Mild-to-Moderate Ulcerative Colitis MB310, Placebo, Vancomycin - Ulcerative Colitis | Phase 1 | Completed | Microbiotica Ltd | 29 | 2024-09-27 | 2026-06-15 |
| A Phase 1b Trial to Evaluate Safety of MB097 in Combination With Pembrolizumab in Melanoma Patients MB097, Pembrolizumab, Vancomycin - Melanoma | Phase 1 | Active not recruiting | Microbiotica Ltd | 41 | 2024-08-28 | 2025-09-26 |
| Combination Study of Antibiotics With Enzalutamide (PROMIZE) Enzalutamide 40mg, Amoxicillin 500mg, Metronidazole 400mg - Metastatic Castration-Resistant Prostate Cancer (mCRPC) | Phase 1 / Phase 2 | Recruiting | Institute of Cancer Research, United Kingdom | 39 | 2023-11-02 | 2025-11-24 |
| Clostridioides Difficile Colonisation 10E4 NTCD spores, 10E7 NTCD spores, placebo - Clostridioides Difficile Infection | Phase 1 | Unknown | Leiden University Medical Center | 70 | 2023-09-22 | 2023-10-17 |
| Vancomycin Study in Multiple Sclerosis (MS) Vancomycin, Placebo - Multiple Sclerosis | Phase 1 | Recruiting | Icahn School of Medicine at Mount Sinai | 12 | 2023-01-31 | 2026-09-28 |
| Application of Fecal Microbiota Transplantation in Children With ASD Fecal microbiota transplantation, Vancomycin - Autism Spectrum Disorder | Phase 1 | Unknown | Tongji Hospital | 40 | 2022-06-01 | 2023-01-20 |
| Antibiotics Continuous Infusion at Home Cefepime, Piperacillin/tazobactam, Meropenem - Severe Bacterial Infections | Phase 1 | Unknown | Ospedale San Carlo Borromeo | 50 | 2021-09-01 | 2021-03-25 |
| Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration Systemic IV Vancomycin, Bier Block, Vancomycin - Infection, Hand Injury Wrist | Phase 1 | Completed | Mayo Clinic | 20 | 2021-08-26 | 2022-10-07 |
| Microbiome Effect of Omadacycline on Healthy Volunteers Omadacycline, Vancomycin Pill, Moxifloxacin - Healthy Volunteers | Phase 1 | Completed | University of Houston | 32 | 2020-10-12 | 2025-03-25 |
| Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer VE800, Nivolumab, Vancomycin Oral Capsule - Metastatic Cancer, Melanoma | Phase 1 / Phase 2 | Completed | Vedanta Biosciences, Inc. | 56 | 2020-01-23 | 2025-10-27 |
| Fecal Microbiota Transplant for Primary CDI Fecal microbiota transplant G3 capsules, Oral Vancomycin alone - Clostridium Difficile Infection | Phase 1 / Phase 2 | Terminated | Boston Medical Center | 5 | 2019-08-23 | 2021-12-15 |
| Vancomycin for the Treatment of NAAT(+)/Toxin(-) C. Difficile Vancomycin Oral Capsule, Placebo Oral Capsule - Clostridium Difficile Infection | Phase 1 | Completed | Medical College of Wisconsin | 7 | 2019-07-17 | 2021-10-20 |
| VE416 for Treatment of Food Allergy Vancomycin plus VE416 before PNOIT, Vancomycin plus VE416 with PNOIT, Placebo plus VE416 with PNOIT - Peanut Allergy | Phase 1 / Phase 2 | Recruiting | Massachusetts General Hospital | 60 | 2019-06-28 | 2023-10-18 |
Showing 20 of 39. Sign in to see all of them.
Cholangitis, Sclerosing (4) · Clostridium Infections (4) · Colitis, Ulcerative (3) · Autism Spectrum Disorder (2) · Biliary Atresia (2) · Cystic Fibrosis (2) · Disease (2) · Infections (2) · Melanoma (2) · Bacterial Infections (1) · Colorectal Neoplasms (1) · Critical Illness (1) · Dysbiosis (1) · Hand Injuries (1) · Heart Failure (1)
Mayo Clinic (4) · Abramson Cancer Center at Penn Medicine (2) · Microbiotica Ltd (2) · Vedanta Biosciences, Inc. (2) · Aarhus University Hospital (1) · Arizona State University (1) · Boston Medical Center (1) · Case Western Reserve University (1) · Drexel University (1) · Icahn School of Medicine at Mount Sinai (1) · Institute of Cancer Research, United Kingdom (1) · Isfahan University of Medical Sciences (1) · Johns Hopkins University (1) · Leiden University Medical Center (1) · Massachusetts General Hospital (1)
United States (24) · United Kingdom (3) · China (2) · Italy (2) · Spain (2) · Australia (1) · Austria (1) · Bulgaria (1) · Canada (1) · France (1) · Iran (1) · Japan (1) · Netherlands (1) · Poland (1) · South Korea (1)
Byron P Vaughn, MD (1) · Dina Kao, MD (1) · Elise Chong, MD (1) · Elliott C Dasenbrook, MD MHS (1) · Erin Frazee, PharmD, RPh (1) · Garret W Choby, MD (1) · James B Adams, PhD (1) · Jayant A Talwalkar, MD (1) · Jeffrey J Cies, PharmD, MPH (1) · Johann De Bono, MD (1) · Judy Wang, MD (1) · Kenneth L Cox, MD (1) · Kevin Renfree, MD (1) · Kevin W Garey (1) · Lawrence G Lenke, MD (1)
PMID 23054338, PMID 23384404, PMID 28122648, PMID 30967657, PMID 32633158, PMID 33087514, PMID 33463542, PMID 33631102, PMID 34755479, PMID 35365713, PMID 38051631, PMID 39819014, PMID 40639850, PMID 41081530
2023 (2), R21AI182531 (1)