15 completed, 3 recruiting, 3 withdrawn, 2 not yet recruiting. 25 Phase 3, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 15, Recruiting 3, Withdrawn 3, Not yet recruiting 2, Active not recruiting 1, Unknown 1 |
| Phase 2 | 8 | Completed 5, Active not recruiting 1, Recruiting 1, Withdrawn 1 |
Follow Thyroxine: new trials by email Literature Review of Thyroxine trials Research Report on Thyroxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Desiccated Thyroid Extract Combined With Levothyroxine for TSH Suppression Therapy in DTC desiccated thyroid extract (DTE)+levothyroxine (L-T4) - Intermediate-to-High Risk Differentiated Thyroid Cancer | Phase 3 | Not yet recruiting | West China Hospital | 646 | 2025-11-30 | 2025-11-20 |
| Levothyroxine as Adjuvant to a Hypocaloric Diet for the Treatment of Obesity. Levothyroxine, Placebo - Obesity | Phase 3 | Recruiting | Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud | 286 | 2025-11-05 | 2026-01-12 |
| LIGHT Trial: Levothyroxine for Gestational Hypothyroidism in Recurrent Pregnancy Loss Levothyroxin, Placebo - Abortion, Habitual | Phase 3 | Not yet recruiting | Women's Hospital School Of Medicine Zhejiang University | 200 | 2025-06-01 | 2025-06-04 |
| Novel Approaches to the Treatment of Hypothyroidism Levothyroxine, Levothyroxine/Liothyronine once daily, Levothyroxine/Liothyronine twice daily - Hypothyroidism | Phase 2 / Phase 3 | Recruiting | UConn Health | 90 | 2024-12-10 | 2026-03-19 |
| Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery L-thyroxine, Placebo Oral Tablet - Cardiac Surgery Intensive Care Treatment, Delayed Recovery From Anaesthesia | Phase 3 | Completed | Ain Shams University | 70 | 2024-11-30 | 2025-08-17 |
| A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants Armour Thyroid, Levothyroxine - Hypothyroidism | Phase 2 / Phase 3 | Active not recruiting | AbbVie | 2701 | 2024-04-26 | 2026-10-13 |
| Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism Vitamin D, Levothyroxin - Hypothyroidism Primary, Lipid Disorder | Phase 3 | Completed | King Edward Medical University | 62 | 2024-03-01 | 2025-03-11 |
| Thyroxine Therapy for Recurrent Pregnancy Loss in Hypothyroid Women Levothyroxine Pill - Recurrent Early Pregnancy Loss, Thyroid Diseases | Phase 3 | Completed | Al-Kindy College of Medicine | 77 | 2022-03-01 | 2023-09-14 |
| Thyroxine Treatment in Premature Infants With Intraventricular Hemorrhage Thyroxine, Placebo - Intraventricular Hemorrhage of Prematurity | Phase 3 | Withdrawn | Albert Einstein College of Medicine | 2022-01-18 | 2022-07-08 | |
| TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients Levothyroxine - Hypothyroidism; Irradiation | Phase 3 | Recruiting | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | 68 | 2021-12-13 | 2023-12-06 |
| Intravenous Thyroxine for Heart-Eligible Organ Donors Thyroxine, Saline - Brain Death, Heart Failure | Phase 3 | Completed | Washington University School of Medicine | 838 | 2020-12-01 | 2024-01-10 |
| Study of Thyroid Hormones in Prematures thryoid hormone T4 + oral potassium iodide (KI) for 42 days, D5W - 5% dextrose water - Transient Hypothyroxinemia of Prematurity (THOP) | Phase 3 | Withdrawn | New York Medical College | 2020-07-01 | 2019-04-24 | |
| Supplementation of Thyroid Hormone for TSH Control in Patients With Chronic Kidney Disease Without TRR. Levothyroxine - Chronic Kidney Diseases, Subclinical Hypothyroidism | Phase 3 | Completed | Hospital Civil de Guadalajara | 32 | 2018-10-01 | 2019-04-02 |
| Efficacy of Low Dose Levothyroxine During Pregnancy levothyroxin - Euthyroid Females | Phase 3 | Completed | Ain Shams University | 180 | 2017-05-01 | 2021-10-07 |
| Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients Liothyronine, Levothyroxin, Placebos - Hypothyroidism | Phase 2 / Phase 3 | Completed | Azienda USL Modena | 160 | 2017-03-14 | 2023-04-21 |
| Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Levothyroxine, Placebo - Hypothyroidism, Neoplasms | Phase 2 / Phase 3 | Withdrawn | University of Alberta | 2015-07-01 | 2022-07-13 | |
| Early Levothyroxine Post Radioactive Iodine Levothyroxine, Placebo - Graves' Disease | Phase 2 / Phase 3 | Completed | Mayo Clinic | 61 | 2013-09-01 | 2019-10-29 |
| Effects of Levothyroxine on Endothelial Function of Patients With Subclinical Hypothyroidism Levothyroxine, Placebo - Subclinical Hypothyroidism | Phase 2 / Phase 3 | Completed | Isfahan University of Medical Sciences | 50 | 2013-05-01 | 2014-03-18 |
| Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP levothyroxine, sugar pill - Dyslipidemia | Phase 3 | Unknown | King Saud University | 200 | 2011-10-01 | 2011-12-08 |
| Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation, The initiation of LT4 as soon as the first biological signs of hypothyroidism. - Graves Disease (Basedow's Disease) | Phase 3 | Completed | Assistance Publique Hopitaux De Marseille | 200 | 2011-05-01 | 2015-04-22 |
Showing 20 of 25. Sign in to see all of them.
Hypothyroidism (8) · Thyroid Diseases (6) · Abortion, Habitual (2) · Dyslipidemias (2) · Graves Disease (2) · Abortion, Spontaneous (1) · Atherosclerosis (1) · Bipolar Disorder (1) · Bites and Stings (1) · Brain Death (1) · Cardiovascular Diseases (1) · Cerebral Palsy (1) · Cognitive Dysfunction (1) · Delayed Emergence from Anesthesia (1) · Euthyroid Sick Syndromes (1)
Ain Shams University (2) · AbbVie (1) · Al-Kindy College of Medicine (1) · Albert Einstein College of Medicine (1) · Assistance Publique Hopitaux De Marseille (1) · Azienda USL Modena (1) · Centre Hospitalier Universitaire, Amiens (1) · Charite University, Berlin, Germany (1) · Fondazione IRCCS Istituto Nazionale dei Tumori, Milano (1) · Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud (1) · Hospital Civil de Guadalajara (1) · Isfahan University of Medical Sciences (1) · King Edward Medical University (1) · King Saud University (1) · Mayo Clinic (1)
United States (8) · Egypt (2) · France (2) · Italy (2) · Mexico (2) · China (1) · Germany (1) · Iran (1) · Iraq (1) · Pakistan (1) · Puerto Rico (1) · Saudi Arabia (1) · Spain (1) · United Kingdom (1)
Brian Casey, MD (1) · Edmund F La Gamma, MD (1) · Francesco Celi (1) · Jesus Z Villarreal-Perez, M.D. (1) · Jonathan Chavez (1) · Lilia Cardenas-Ibarra, M.D. (1) · Marius Stan, MD (1) · Menachem Miodovnik, MD (1) · Nasmi Niknam, M.D. (1) · Pierre Tourneux, MD (1) · Qiong Luo, Ph.D. (1) · Rajat Dhar, MD (1)
PMID 19581264, PMID 24345793, PMID 28249134, PMID 28960722, PMID 31583561, PMID 33178770, PMID 33662333, PMID 34302730, PMID 34670546, PMID 34838132, PMID 34856574, PMID 34935859, PMID 35639050, PMID 37668013, PMID 40844370, PMID 42492995
U10HD021410 (1), U10HD027860 (1), U10HD027869 (1), U10HD027915 (1), U10HD027917 (1), U10HD034116 (1), U10HD034136 (1), U10HD034208 (1), U10HD036801 (1), U10HD040485 (1), U10HD040500 (1), U10HD040512 (1), U10HD040544 (1), U10HD040545 (1), U10HD040560 (1)