17 completed, 3 recruiting, 2 not yet recruiting, 1 active not recruiting. 26 Phase 2, 8 Phase 3, 3 Phase 1.
Follow Thyroxine: new trials by email Literature Review of Thyroxine trials Research Report on Thyroxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COACH - Comparing Two Different Methods to Suppress Thyrotropin in Patients With Advanced Thyroid Cancer Levothyroxine Oral Tablet [Synthroid] - Advanced Differentiated Thyroid Gland Carcinoma | Phase 2 | Not yet recruiting | AHS Cancer Control Alberta | 70 | 2026-12-01 | 2026-02-06 |
| T4/T3 Therapy in Hypothyroidism Liothyronine (L-T3), Levothyroxine Sodium (LT4) Tablets, Liothyronine (LT3) placebo - Hypothyroidism Primary | Phase 2 | Not yet recruiting | University of Pennsylvania | 60 | 2026-11-01 | 2026-08-20 |
| Novel Approaches to the Treatment of Hypothyroidism Levothyroxine, Levothyroxine/Liothyronine once daily, Levothyroxine/Liothyronine twice daily - Hypothyroidism | Phase 2 / Phase 3 | Recruiting | UConn Health | 90 | 2024-12-10 | 2026-03-19 |
| A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants Armour Thyroid, Levothyroxine - Hypothyroidism | Phase 2 / Phase 3 | Active not recruiting | AbbVie | 2701 | 2024-04-26 | 2026-10-13 |
| Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism levothyroxine sodium - Hypothyroidism | Phase 2 | Completed | Xeris Pharmaceuticals | 46 | 2023-05-15 | 2025-07-03 |
| Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans Synthroid, Placebo - Nonalcoholic Steatohepatitis, Liver Fibrosis | Phase 2 | Recruiting | VA Office of Research and Development | 128 | 2023-04-01 | 2026-02-19 |
| A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism North Star, Levothyroxine - Hypothyroidism | Phase 2 | Completed | Neuvosyn Laboratories, LLC | 303 | 2023-02-28 | 2026-02-18 |
| Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid Carcinoma Thyroxine - Thyroid Cancer, Surgery | Phase 2 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 140 | 2022-08-01 | 2023-10-17 |
| A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism ST-1891, Levothyroxine - Hypothyroidism | Phase 2 | Completed | Sention Therapeutics, LLC | 490 | 2022-04-29 | 2024-08-26 |
| Energy Metabolism in Thyroidectomized Patients Levothyroxine, Liothyronine, Placebo - Thyroid Goiter, Hypothyroidism | Phase 2 | Completed | Virginia Commonwealth University | 13 | 2020-10-28 | 2024-06-14 |
| Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women acupuncture, Thyroxine, low caloric diet - Primary Hypothyroidism, Acupuncture | Phase 2 | Completed | Cairo University | 60 | 2020-08-30 | 2023-04-07 |
| Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism? Levothyroxine - Subclinical hypothyroïdism | Phase 1 / Phase 2 | Unknown | Ain Shams University | 40 | 2020-01-01 | 2019-11-29 |
| A Study of Armour® Thyroid Compared to Synthetic T4 (Levothyroxine) in Previously Hypothyroid Participants Armour® Thyroid, Levothyroxine - Hypothyroidism, Thyroid Disease | Phase 2 | Completed | Allergan | 284 | 2019-10-11 | 2024-06-05 |
| Identification of Non-responders to Levothyroxine Therapy Levothyroxin, Liothyronine - Hypothyroidism, Biomarkers | Phase 2 | Completed | Oslo University Hospital | 69 | 2018-08-14 | 2021-03-17 |
| The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis Immunomodulatory, Thyroxine - Infertility, Autoimmune Thyroiditis | Phase 2 | Completed | Aljazeera Hospital | 194 | 2018-03-07 | 2024-12-27 |
| Effects of Liothyronine on Energy Expenditure and Cardiovascular Function Liothyronine, Levothyroxine, Placebos - Healthy | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 22 | 2017-10-20 | 2021-03-26 |
| Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients Liothyronine, Levothyroxin, Placebos - Hypothyroidism | Phase 2 / Phase 3 | Completed | Azienda USL Modena | 160 | 2017-03-14 | 2023-04-21 |
| Levothyroxine Treatment for Subclinical Hypothyroidism After Head and Neck Surgery Levothyroxine, Placebo - Hypothyroidism, Neoplasms | Phase 2 / Phase 3 | Withdrawn | University of Alberta | 2015-07-01 | 2022-07-13 | |
| Levothyroxine for Non-Alcoholic Fatty Liver Disease (NAFLD) Levothyroxine Sodium - Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2 | Phase 2 | Terminated | Duke-NUS Graduate Medical School | 29 | 2014-03-28 | 2017-09-14 |
| Early Levothyroxine Post Radioactive Iodine Levothyroxine, Placebo - Graves' Disease | Phase 2 / Phase 3 | Completed | Mayo Clinic | 61 | 2013-09-01 | 2019-10-29 |
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Hypothyroidism (13) · Thyroid Diseases (4) · Non-alcoholic Fatty Liver Disease (2) · Thyroid Neoplasms (2) · Atherosclerosis (1) · Bipolar Disorder (1) · Brain Death (1) · Cardiovascular Diseases (1) · Cognitive Dysfunction (1) · Diabetes Mellitus, Type 2 (1) · Endocrine System Diseases (1) · Goiter (1) · Graves Disease (1) · Infertility (1) · Liver Cirrhosis (1)
Virginia Commonwealth University (2) · AHS Cancer Control Alberta (1) · AbbVie (1) · Ain Shams University (1) · Aljazeera Hospital (1) · Allergan (1) · Azienda USL Modena (1) · Cairo University (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Charite University, Berlin, Germany (1) · Duke-NUS Graduate Medical School (1) · Isfahan University of Medical Sciences (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1)
United States (14) · Egypt (2) · Canada (1) · China (1) · Germany (1) · Iran (1) · Italy (1) · Mexico (1) · Norway (1) · Puerto Rico (1)
Ahmed M Sayed, Prof. (1) · Alice P Chen, M.D. (1) · Angeliki M Stamatouli, MD (1) · Erik Fink Eriksen, Professor (1) · Francesco Celi (1) · Francesco S Celi, MD, MHSc. (1) · Jamal A Ibdah, MD PhD (1) · Jesus Z Villarreal-Perez, M.D. (1) · Kong Y Chen, Ph.D. (1) · Lilia Cardenas-Ibarra, M.D. (1) · Marius Stan, MD (1) · Michael D Sharpe, MD FRCPC (1) · Nasmi Niknam, M.D. (1)
PMID 20447070, PMID 21865366, PMID 23585666, PMID 23884915, PMID 24345793, PMID 29718334, PMID 31583561, PMID 34867829, PMID 35273566, PMID 35295986, PMID 35572853, PMID 36302173
2017 (1), I01CX002436 (1), R01DK137207 (1), R21DK122310 (1)