18 completed, 10 unknown, 5 terminated, 4 withdrawn. 41 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 41 | Completed 18, Unknown 10, Terminated 5, Withdrawn 4, Not yet recruiting 2, Active not recruiting 1, Recruiting 1 |
Follow Thyroxine: new trials by email Literature Review of Thyroxine trials Research Report on Thyroxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism Levothyroxine Pill, Placebo - Hypothyroidism | Phase 4 | Not yet recruiting | Spyridoula Maraka | 138 | 2027-10-01 | 2026-08-26 |
| Levothyroxine Dosing in Neonatal Congenital Hypothyroidism Levothyroxine - Congenital Hypothyroidism | Phase 4 | Completed | Menoufia University | 101 | 2025-11-02 | 2026-08-10 |
| Comparison of Two Timings of Levothyroxine Intake in Hypothyroid Patients: A Cross-over Randomized Control Trial Levothyroxine Pill - Hypothyroidism Primary | Phase 4 | Active not recruiting | Elyes Kamoun | 102 | 2025-07-24 | 2026-10-28 |
| Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody Levothyroxine Sodium (LT4) Tablets, Placebo - Thyroid Abnormalities, Pregnant Woman | Phase 4 | Not yet recruiting | Yang ZHANG | 400 | 2024-10-25 | 2024-10-23 |
| Effect of Krill Oil Supplementation on Red Blood Cell Physiology Against Changes in Markers of Iron Metabolism. THYROX (Atlantic krill oil)., Placebo - Red Blood Cell Disorder, Oxidative Stress | Phase 4 | Unknown | Poznan University of Physical Education | 30 | 2024-03-23 | 2024-03-19 |
| Dosing of LT4 in Older Individuals Levothyroxine Sodium - Hypothyroidism | Phase 4 | Recruiting | University of Pennsylvania | 228 | 2024-01-31 | 2026-02-19 |
| Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH) Tirosint®-SOL, Levothyroxine Sodium - Congenital Hypothyroidism | Phase 4 | Terminated | IBSA Institut Biochimique SA | 34 | 2022-01-21 | 2026-06-26 |
| Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding Levothyroxine Tablet, Levothyroxine Sodium - Hypothyroidism | Phase 4 | Terminated | University of California, Los Angeles | 3 | 2021-05-05 | 2023-04-10 |
| Discontinuation of Levothyroxine Therapy for Patients With Subclinical Hypothyroidism Levothyroxine, Placebo - Subclinical Hypothyroidism | Phase 4 | Completed | VA Office of Research and Development | 52 | 2021-03-24 | 2023-11-18 |
| Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients Liquid stable levothyroxine (L-T4) Tirosint-SOL, Oral tablet levothyroxine (L-T4) - Hypothyroidism, Trisomy 21 | Phase 4 | Terminated | Children's Mercy Hospital Kansas City | 6 | 2021-01-18 | 2023-09-13 |
| Low Dose Euthyrox in Treatments of Paraquat Intoxication. Levothyroxine Sodium, Traditional therapy - Paraquat Poisoning | Phase 4 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 80 | 2020-01-01 | 2019-10-22 |
| Thyroid Replacement Therapy in Patients With Subclinical Hypothyroidism Levothyroxine Sodium Tablets - Subclinical Hypothyroidisms | Phase 4 | Unknown | Beijing Chao Yang Hospital | 30 | 2019-01-01 | 2021-07-07 |
| Levothyroxine Sodium in Thyroidectomized Patients Taking Proton Pump Inhibitors levothyroxine sodium capsule, Proton pump inhibitor (PPI), Levothyroxine Sodium (LT4) Tablets - Hypothyroidism;Postablative | Phase 4 | Completed | IBSA Institut Biochimique SA | 66 | 2018-07-30 | 2022-04-05 |
| Treatment With Prednisone of Women With RPL or RIF Positive to Antithyroid Antibodies and Embryotoxicity Test Prednisone - Recurrent Pregnancy Loss, Not Pregnant, Recurrent Implantation Failure | Phase 4 | Completed | Centre for Endocrinology and Reproductive Medicine, Italy | 42 | 2018-01-01 | 2024-10-16 |
| Thyroid Hormone Replacement for Subclinical Hypothyroidism and Chronic Heart Failure (ThyroHeart-CHF) Levothyroxine - Heart Failure, Subclinical Hypothyroidism | Phase 4 | Unknown | Chinese Academy of Medical Sciences, Fuwai Hospital | 124 | 2017-04-18 | 2018-03-29 |
| Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy Levothyroxine - Thyroid Cancer, Postsurgical Hypothyroidism | Phase 4 | Terminated | University of Texas Southwestern Medical Center | 14 | 2017-02-01 | 2020-12-01 |
| The TRUST Trial - CardioVascular Imaging ECHO Levothyroxine, Placebo - Thyroid Dysfunction, Atherosclerosis | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 185 | 2016-06-01 | 2017-02-28 |
| The TRUST Study - CardioVascular Imaging IMT Levothyroxine, Placebo - Thyroid Dysfunction, Atherosclerosis | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 184 | 2016-06-01 | 2017-02-28 |
| Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism L-Thyroxine (tablet, per os), L-Thyroxine (oral drops, solution) - Hypothyroidism | Phase 4 | Unknown | Meyer Children's Hospital IRCCS | 70 | 2016-05-01 | 2016-09-28 |
| Effects of Levothyroxine Treatment on Hemodynamic and Renal Functions in Subclinical Hypothyroidism LEVOTHYROXINE - Subclinical hypothyroïdism | Phase 4 | Withdrawn | Centre Hospitalier Universitaire de Nice | 2015-10-01 | 2016-10-28 |
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Hypothyroidism (17) · Atherosclerosis (3) · Congenital Hypothyroidism (3) · Heart Failure (3) · Thyroid Diseases (3) · Endocrine System Diseases (2) · Brain Death (1) · COVID-19 (1) · Cardiovascular Diseases (1) · Celiac Disease (1) · Depression (1) · Diabetes Mellitus (1) · Down Syndrome (1) · Euthyroid Sick Syndromes (1) · Eye Diseases (1)
Insel Gruppe AG, University Hospital Bern (6) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · IBSA Institut Biochimique SA (2) · Shandong Provincial Hospital (2) · Beijing Chao Yang Hospital (1) · Centre Hospitalier Universitaire de Nice (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · Centre for Endocrinology and Reproductive Medicine, Italy (1) · Children's Mercy Hospital Kansas City (1) · Elyes Kamoun (1) · Federico II University (1) · GlaxoSmithKline (1) · Jocelyne Karam (1) · Johns Hopkins University (1) · Maastricht University Medical Center (1)
United States (11) · China (6) · Switzerland (6) · Netherlands (3) · Italy (2) · United Kingdom (2) · Australia (1) · Canada (1) · Egypt (1) · France (1) · Germany (1) · India (1) · Ireland (1) · Mexico (1) · Poland (1)
Nicolas Rodondi, MD MAS (5) · Jacobijn Gussekloo, MD (2) · Alex Tessnow, MD (1) · Anne Julie Frenette, M.Sc (1) · Anne R. Cappola, M.D., Sc.M. (1) · Daniela A Marconi, MD (1) · David J Stott, MBChB MD (1) · Giuseppe Mautone (1) · Guang Wang, MD (1) · Jan Calissendorff, MD (1) · Jesus J Martinez, MD (1) · Jiajun Zhao (1) · Jocelyne Karam, MD (1)
PMID 31702015, PMID 35381390, PMID 36721961, PMID 15247962, PMID 16275864, PMID 17711927, PMID 17964598, PMID 21568669, PMID 21765997, PMID 22134702, PMID 23124142, PMID 23448784, PMID 23773982, PMID 24157158, PMID 24423358, PMID 24951271, PMID 24969506, PMID 26700485, PMID 27338133, PMID 27766119, PMID 28158982, PMID 28402245, PMID 28460140, PMID 28473851, PMID 29509918, PMID 29846630, PMID 30165520, PMID 30782213, PMID 31179831, PMID 31664429, PMID 32365355, PMID 32577745, PMID 33072620, PMID 33566107, PMID 34093444, PMID 35218666, PMID 36133316, PMID 37862463, PMID 37885233, PMID 38537636, PMID 40736623
2005 (1), 2015 (1), R01AG081698 (1)