16 completed, 1 recruiting, 1 unknown, 1 withdrawn. 19 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 19 | Completed 16, Recruiting 1, Unknown 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Thyroxine: new trials by email Literature Review of Thyroxine trials Research Report on Thyroxine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028) Levothyroxine, Enlicitide Decanoate - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2024-07-08 | 2024-10-03 |
| Levothyroxine Supplementation for Heart Transplant Recipients Levothyroxine, Normal saline - Heart Transplant Failure, Heart Transplant Infection | Phase 1 | Recruiting | University of California, San Francisco | 97 | 2024-03-29 | 2026-08-13 |
| BE of Euthyrox® Tablets (Merck Nantong Versus Merck Darmstadt Sites) Test Euthyrox®, Reference Euthyrox® - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 56 | 2022-01-10 | 2022-11-25 |
| Levothyroxine-sodium Bioequivalence Trial With Oral Single Dose Administration Levothyroxin - Healthy | Phase 1 | Completed | Berlin-Chemie AG Menarini Group | 132 | 2021-10-22 | 2024-08-09 |
| Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer Thyrotropin Releasing Hormone (TRH), levothyroxine, Hypothyroidism QOL questionnaire - Thyroid Cancer | Phase 1 | Withdrawn | Memorial Sloan Kettering Cancer Center | 2021-04-27 | 2023-02-21 | |
| Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism? Levothyroxine - Subclinical hypothyroïdism | Phase 1 / Phase 2 | Unknown | Ain Shams University | 40 | 2020-01-01 | 2019-11-29 |
| Bioequivalence of Two Formulations of Levothyroxine Sodium 200 Micrograms (mcg) Under Tablet Form Puran T4®, Eutirox® - Healthy | Phase 1 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 72 | 2019-06-25 | 2020-09-29 |
| Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Digoxin in Healthy Adult Volunteers Microgestin®, Levothyroxine, Glyburide - Healthy Volunteers | Phase 1 | Completed | Ironwood Pharmaceuticals, Inc. | 87 | 2019-03-11 | 2019-07-29 |
| Effects of Liothyronine on Energy Expenditure and Cardiovascular Function Liothyronine, Levothyroxine, Placebos - Healthy | Phase 1 / Phase 2 | Completed | Virginia Commonwealth University | 22 | 2017-10-20 | 2021-03-26 |
| A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects. Semaglutide, SNAC, Levothyroxine - Diabetes, Healthy | Phase 1 | Completed | Novo Nordisk A/S | 45 | 2016-10-10 | 2017-12-14 |
| Sorafenib Drug Drug Interaction Study in Healthy Male Subjects Sorafenib (Nexavar, BAY43-9006), Levothyroxine - Drug Interactions | Phase 1 | Completed | Bayer | 25 | 2015-02-01 | 2015-10-12 |
| Iron Deficiency Anemia Can be an Indication for Treatment of Subclinical Hypothyroidism Ferrous sulfate tablets 325 mg, po, TID, Ferrous sulfate plus levothyroxine - Iron Deficiency Anemia, Subclinical Hypothyroidism | Phase 1 | Completed | Duzce University | 2007-06-01 | 2012-02-17 | |
| Fasting Study of Levothyroxine Sodium Tablets 300 mcg to Synthroid® Tablets 300 mcg LEVOTHYROXINE SODIUM TABLETS,, SYNTHROID® 300 mcg Tablets - Healthy | Phase 1 | Completed | Mylan Pharmaceuticals Inc | 33 | 2007-03-01 | 2024-04-24 |
| Fasting Study of Levothyroxine Sodium Tablets 300 μg to Levothroid® Tablets 300 μg Levothyroxine Sodium Tablets 300 μg, Levothroid® Tablets 300 μg - Healthy | Phase 1 | Completed | Mylan Pharmaceuticals Inc | 32 | 2005-08-01 | 2024-04-24 |
| Thyroxine Replacement in Organ Donors L-thryoxine, iv thryoxine - Brain Death | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 34 | 2004-12-01 | 2011-01-05 |
| Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 50 μg/ 75 μg Tablets levothyroxine - Pharmacokinetics | Phase 1 | Completed | Heidelberg University | 24 | 2003-08-01 | 2011-11-07 |
| Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets levothyroxine - Pharmacokinetics | Phase 1 | Completed | Heidelberg University | 24 | 2003-06-01 | 2011-11-07 |
| Fasting Study of Levothyroxine Sodium Tablets 300 μg to Synthroid® Tablets 300 μg Levothyroxine Sodium Tablets 300 μg, Synthroid® Tablets 300 μg - Healthy | Phase 1 | Completed | Mylan Pharmaceuticals Inc | 30 | 2003-05-01 | 2024-04-24 |
| Fasting Study of Levothyroxine Sodium Tablets 200 mg to Synthroid Tablets 200 mg Levothyroxine Sodium Tablets 200 mg, Synthroid Tablets 200 mg - Healthy | Phase 1 | Completed | Mylan Pharmaceuticals Inc | 32 | 2003-01-01 | 2024-04-24 |
Anemia (1) · Anemia, Iron-Deficiency (1) · Brain Death (1) · Diabetes Mellitus (1) · Hypothyroidism (1) · Thyroid Neoplasms (1)
Mylan Pharmaceuticals Inc (4) · Heidelberg University (2) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (2) · Ain Shams University (1) · Bayer (1) · Berlin-Chemie AG Menarini Group (1) · Duzce University (1) · Ironwood Pharmaceuticals, Inc. (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Memorial Sloan Kettering Cancer Center (1) · Merck Sharp & Dohme LLC (1) · Novo Nordisk A/S (1) · University of California, San Francisco (1) · Virginia Commonwealth University (1)
United States (8) · Germany (5) · Brazil (1) · Canada (1) · China (1) · Turkey (Türkiye) (1)
James D Carlson, Pharm. D. (3) · Alan K Copa, Pharm. D. (1) · Francesco S Celi, MD, MHSc. (1) · Hakan Cinemre, Assit. Prof. (1) · Jason Smith, MD (1) · Michael D Sharpe, MD FRCPC (1) · Stephanie Fish, MD (1) · Zurab Machaidze, MD (1)
2014 (1), 2015 (1)