14 completed, 3 active not recruiting, 1 recruiting, 1 unknown. 19 Phase 2, 5 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 19 | Completed 14, Active not recruiting 3, Recruiting 1, Unknown 1 |
| Phase 3 | 5 | Completed 4, Unknown 1 |
| Phase 1 | 3 | Completed 2, Active not recruiting 1 |
Follow Theophylline: new trials by email Literature Review of Theophylline trials Research Report on Theophylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage Single Dose Theophylline, Repeat Dose Theophylline - Acute Kidney Injury, HIE | Phase 1 / Phase 2 | Active not recruiting | Medical College of Wisconsin | 30 | 2023-10-17 | 2026-06-23 |
| Theophylline Effects in the Fontan Circulation Theophylline Tablets - Congenital Heart Disease | Phase 2 | Completed | Oslo University Hospital | 10 | 2023-02-09 | 2023-09-21 |
| Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3) theophylline, Placebo - COVID-19 | Phase 2 | Completed | Washington University School of Medicine | 77 | 2022-11-22 | 2025-08-20 |
| Reverse Triple Negative Immune Resistant Breast Cancer Choline, anti-PD-1 antibody and chemotherapy, Sodium Cromoglicate - Triple-negative Breast Cancer | Phase 2 | Recruiting | Fudan University | 90 | 2022-06-30 | 2026-10-23 |
| Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old Theophylline, Placebo - Pseudohypoparathyroidism, Albright Hereditary Osteodystrophy | Phase 2 | Active not recruiting | Vanderbilt University Medical Center | 34 | 2020-07-13 | 2026-04-29 |
| Smell Changes & Efficacy of Nasal Theophylline Theophylline, Saline Nasal - Olfactory Disorder, Anosmia | Phase 2 | Completed | Washington University School of Medicine | 27 | 2019-05-15 | 2022-03-31 |
| Theophylline Treatment for Pseudohypoparathyroidism Theophylline, Placebos - Pseudohypoparathyroidism, Albright Hereditary Osteodystrophy | Phase 2 | Active not recruiting | Vanderbilt University Medical Center | 29 | 2018-09-01 | 2026-09-02 |
| Helping Olfaction and Nutrition On Renal Replacement Theophylline - End Stage Renal Disease, Olfactory Disorders | Phase 2 | Completed | Massachusetts General Hospital | 7 | 2015-10-01 | 2024-01-09 |
| Theophylline as a Treatment for Children With Pseudohypoparathyroidism Type 1a (Albright Hereditary Osteodystrophy) Theophylline - Pseudohypoparathyroidism Type 1a, Albright Hereditary Osteodystrophy | Phase 2 | Completed | Vanderbilt University Medical Center | 6 | 2015-06-01 | 2017-06-26 |
| Theophylline, N-acetylcysteine, and Theophylline Plus N-acetylcysteine in Preventing Contrast-induced Nephropathy N-acetylcysteine, Theophylline, 0.9% sodium chloride - Contrast-Induced Nephropathy | Phase 2 / Phase 3 | Unknown | Isfahan University of Medical Sciences | 96 | 2013-09-01 | 2014-03-17 |
| Drug Combination on Exercise Performance at High Altitude ambrisentan and theophylline, placebo - Acute Mountain Sickness | Phase 2 / Phase 3 | Completed | University of Montana | 28 | 2013-08-01 | 2016-02-26 |
| Rapid Acclimatization to Hypoxia at Altitude Placebo, Aminophylline, Methazolamide - Physiological Function in Low Oxygen Environment | Phase 1 / Phase 2 | Completed | Colorado State University | 41 | 2012-06-01 | 2014-10-24 |
| Theophylline in Rhinitis Theophylline (Intervention Group), Placebo (Placebo Group) - Rhinosinusitis, Asthma | Phase 2 | Completed | University of East Anglia | 28 | 2010-05-01 | 2012-08-23 |
| Theophylline in Chronic Obstructive Pulmonary Disease Theophylline - COPD | Phase 2 / Phase 3 | Completed | Ottawa Hospital Research Institute | 24 | 2006-10-01 | 2017-07-07 |
| Enhancement of in-Vitro GC Function in Patients With COPD Fluticasone Propionate, placebo, Theophylline - COPD | Phase 2 | Completed | Imperial College London | 49 | 2006-04-01 | 2019-12-04 |
| Rosiglitazone Versus Theophylline in Asthmatic Smokers rosiglitazone, theophylline, beclomethasone - Asthma | Phase 2 / Phase 3 | Completed | University of Glasgow | 79 | 2005-07-01 | 2010-01-27 |
| Differentiation Induction in Acute Myelogenous Leukemia all-trans retinoic acid (ATRA), Valproic acid, Theophyllin - Acute Myelogenous Leukemia | Phase 1 / Phase 2 | Completed | University of Bergen | 24 | 2004-11-01 | 2015-06-24 |
| CO2 Inhalation as a New Treatment Modality for Apnea of Prematurity CO2 inhalation, Theophylline - Apnea of Prematurity | Phase 2 / Phase 3 | Completed | University of Manitoba | 87 | 2001-08-01 | 2010-03-03 |
| Theophylline in Treating Patients With In Situ, Stage I, or Stage II Chronic Lymphocytic Leukemia theophylline - Leukemia | Phase 2 | Completed | Eastern Cooperative Oncology Group | 1999-08-11 | 2023-06-22 |
Anosmia (3) · Pseudohypoparathyroidism (3) · Asthma (2) · Pulmonary Disease, Chronic Obstructive (2) · Acute Kidney Injury (1) · Altitude Sickness (1) · Apnea (1) · COVID-19 (1) · Dysgeusia (1) · Heart Defects, Congenital (1) · Hypoxia (1) · Inflammation (1) · Kidney Failure, Chronic (1) · Leukemia (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1)
Vanderbilt University Medical Center (3) · Washington University School of Medicine (2) · Colorado State University (1) · Eastern Cooperative Oncology Group (1) · Fudan University (1) · Imperial College London (1) · Isfahan University of Medical Sciences (1) · Massachusetts General Hospital (1) · Medical College of Wisconsin (1) · Oslo University Hospital (1) · Ottawa Hospital Research Institute (1) · University of Bergen (1) · University of East Anglia (1) · University of Glasgow (1) · University of Manitoba (1)
United States (10) · United Kingdom (3) · Canada (2) · Norway (2) · China (1) · Iran (1) · Puerto Rico (1) · South Africa (1)
Jaclyn Tamaroff, MD (2) · Andrew M Wilson (1) · Ashley H Shoemaker, MD, MSCI (1) · Christopher Bell, PhD (1) · Della Makower, MD (1) · Jay F Piccirillo, MD (1) · Jeffrey Segar, MD (1) · Mortaza Arabmomeni, M.D. (1) · Neil C Thomson, MD (1) · Nha Voduc, MD (1) · Oystein Bruserud, MD (1) · Rajiv K. Pruthi, MBBS (1) · Ruben E Alvaro, MD (1) · Sagar U Nigwekar, MD, MMSc (1)
PMID 15356646, PMID 18922099, PMID 19007987, PMID 19196814, PMID 20299628, PMID 22563244, PMID 22829110, PMID 24525446, PMID 26680684, PMID 28877686, PMID 33917201, PMID 40563015
2004 (1)