11 completed, 1 active not recruiting, 1 terminated, 1 withdrawn. 14 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 11, Active not recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
Follow Theophylline: new trials by email Literature Review of Theophylline trials Research Report on Theophylline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Tigulixostat on the Pharmacokinetics of Theophylline Tigulixostat, Theophylline - Gout, Hyperuricemia | Phase 1 | Completed | LG Chem | 24 | 2023-10-31 | 2024-01-03 |
| Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage Single Dose Theophylline, Repeat Dose Theophylline - Acute Kidney Injury, HIE | Phase 1 / Phase 2 | Active not recruiting | Medical College of Wisconsin | 30 | 2023-10-17 | 2026-06-23 |
| Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer gp96-Ig Vaccine, Theophylline, Oxygen - Non-Small Cell Lung Cancer, Non-small-cell Lung Carcinoma | Phase 1 | Withdrawn | Eckhard Podack | 2014-12-01 | 2014-11-17 | |
| A Phase I Dose Escalation Study of Erlotinib in Combination With Theophylline Theophylline, Erlotinib - Non-small Cell Lung Cancer, Advanced Solid Malignancies | Phase 1 | Terminated | AHS Cancer Control Alberta | 15 | 2014-09-01 | 2019-05-03 |
| Rapid Acclimatization to Hypoxia at Altitude Placebo, Aminophylline, Methazolamide - Physiological Function in Low Oxygen Environment | Phase 1 / Phase 2 | Completed | Colorado State University | 41 | 2012-06-01 | 2014-10-24 |
| The Safety Evaluation of Drug Combinations Against High Altitude Pulmonary Hypertension Theophylline and Bambuterol - High Altitude Pulmonary Hypertension | Phase 1 | Completed | Norwegian Armed Forces Medical Service | 20 | 2012-03-01 | 2013-02-26 |
| Safety Evaluation of Aminophylline and Methazolamide Aminophylline, Methazolamide, Aminophylline and Methazolamide - Mountain Sickness | Phase 1 | Completed | Poudre Valley Health System | 16 | 2011-12-01 | 2017-02-10 |
| A Study of LY2216684 and Theophylline in Healthy Subjects LY2216684, Theophylline - Major Depressive Disorder | Phase 1 | Completed | Eli Lilly and Company | 21 | 2010-12-01 | 2019-07-08 |
| A Drug-Drug Interaction Study of Abiraterone Acetate Plus Prednisone With Dextromethorphan and Theophylline in Patients With Metastatic Castration-Resistant Prostate Cancer Abiraterone acetate, Prednisone, Dextromethorphan hydrobromide - Prostate Neoplasms | Phase 1 | Completed | Janssen Research & Development, LLC | 34 | 2010-01-01 | 2013-04-12 |
| Drug-Drug Interaction Study of Colchicine and Theophylline Theophylline, Colchicine - Pharmacokinetics | Phase 1 | Completed | Mutual Pharmaceutical Company, Inc. | 30 | 2008-08-01 | 2010-03-02 |
| Drug - Drug Interaction Study Between Quinine Sulfate and Theophylline Theophylline 300mg, Quinine 648 mg, Theophylline 300 mg - Pharmacokinetics | Phase 1 | Completed | Mutual Pharmaceutical Company, Inc. | 24 | 2007-08-01 | 2009-10-28 |
| Differentiation Induction in Acute Myelogenous Leukemia all-trans retinoic acid (ATRA), Valproic acid, Theophyllin - Acute Myelogenous Leukemia | Phase 1 / Phase 2 | Completed | University of Bergen | 24 | 2004-11-01 | 2015-06-24 |
| Effect of BIIL 284 BS on the Pharmacokinetics of Theophylline in Healthy Male Volunteers BIIL 284 BS, Theophylline, Placebo - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 16 | 2000-05-01 | 2014-10-24 |
| Bioavailability of Two Sustained-release Theophylline Products in Healthy Males anhydrous theophylline, 350 mg, anhydrous theophylline, 300 mg - Healthy | Phase 1 | Completed | Boehringer Ingelheim | 22 | 1998-04-01 | 2014-07-09 |
Carcinoma, Non-Small-Cell Lung (2) · Acute Kidney Injury (1) · Altitude Sickness (1) · Depressive Disorder, Major (1) · Diarrhea (1) · Gout (1) · Hyperuricemia (1) · Hypoxia (1) · Leukemia, Myeloid, Acute (1) · Lung Neoplasms (1) · Motor Activity (1) · Prostatic Neoplasms (1) · Pulmonary edema of mountaineers (1)
Boehringer Ingelheim (2) · Mutual Pharmaceutical Company, Inc. (2) · AHS Cancer Control Alberta (1) · Colorado State University (1) · Eckhard Podack (1) · Eli Lilly and Company (1) · Janssen Research & Development, LLC (1) · LG Chem (1) · Medical College of Wisconsin (1) · Norwegian Armed Forces Medical Service (1) · Poudre Valley Health System (1) · University of Bergen (1)
United States (8) · Canada (2) · Norway (2)
Barrie March, MD (1) · Christopher Bell, PhD (1) · Gary Luckasen, M.D. (1) · Ikechukwu Akunyili, MD (1) · Jeffrey Segar, MD (1) · Matthew Davis, MD (1) · Michael Sawyer, MD (1) · Oystein Bruserud, MD (1) · Thies Schroeder, Ph.D. (1) · Trond-Eirik Strand, M.D., Ph.D. (1)
PMID 18922099, PMID 19007987, PMID 22829110, PMID 26680684, PMID 28877686, PMID 33917201