52 completed, 6 terminated, 6 withdrawn, 4 recruiting. 71 Phase 1, 25 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids 2 mL SunButyrate-TG, Placebo, 4 mL SunButyrate-TG - Congenital Heart Disease (CHD) | Phase 1 / Phase 2 | Recruiting | University of Nebraska | 105 | 2026-11-01 | 2026-10-30 |
| Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair Therapy Clemastine Fumarate, Placebo - Demyelinating Diseases, Demyelination; Corpus Callosum | Phase 1 / Phase 2 | Not yet recruiting | University of California, San Francisco | 44 | 2026-09-15 | 2026-03-11 |
| The Role of Vitamin K on Knee Osteoarthritis Outcomes Vitamin K1 500 µg, K1 1000 µg, Vitamin K2 (MK-7) 300 µg - Osteo Arthritis Knee | Phase 1 / Phase 2 | Active not recruiting | Boston University | 49 | 2025-06-03 | 2026-09-21 |
| Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols Dexamethasone, Placebo - Rhabdomyolysis | Phase 1 | Recruiting | Children's National Research Institute | 50 | 2024-10-01 | 2025-07-03 |
| Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy Clemastine Fumarate, Placebo - Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting | Phase 1 / Phase 2 | Recruiting | University of California, San Francisco | 74 | 2023-08-01 | 2026-07-02 |
| Treatment of Pneumocystis in COPD (the TOPIC Study) Trimethoprim Sulfamethoxazole, Placebo - COPD Exacerbation Acute | Phase 1 / Phase 2 | Terminated | Corewell Health East | 1 | 2022-09-28 | 2023-11-29 |
| Enhancing Parasympathetic Activity to Improve Endothelial Dysfunction, Vascular Oxidative Stress in African Americans Galantamine, Placebo, TENS 7000 - Endothelial Dysfunction | Phase 1 / Phase 2 | Recruiting | Vanderbilt University Medical Center | 160 | 2021-12-20 | 2026-05-18 |
| Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study Placebo capsule, Dronabinol 7.5 milligram oral capsule - Posttraumatic Stress Disorder | Phase 1 | Completed | Wayne State University | 102 | 2021-04-15 | 2025-07-11 |
| Neuroimmune Dysfunction in Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Drinking, Alcohol-Related Disorders | Phase 1 | Completed | University of Maryland, Baltimore | 142 | 2020-02-03 | 2023-12-01 |
| A Trial of Polypodium Leucotomos in Preventing Skin Cancer and Its Precursors Heliocare with Fernblock PLE technology, Sugar Pill - Keratosis, Actinic, Keratosis | Phase 1 | Withdrawn | Massachusetts General Hospital | 2019-07-01 | 2019-03-08 | |
| Altering Memories That Increase Risk of Relapse in Alcohol Use Disorders Rapamycin, Placebo - Alcohol Use Disorder, Alcohol Dependence | Phase 1 | Completed | Medical University of South Carolina | 21 | 2018-07-12 | 2021-01-27 |
| Orthostatic Intolerance After Bariatric Surgery Atomoxetine, Placebo - Orthostatic Intolerance | Phase 1 | Terminated | Vanderbilt University Medical Center | 10 | 2018-07-01 | 2024-09-27 |
| Minocycline for Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Use Disorder, Inflammation | Phase 1 / Phase 2 | Withdrawn | University of California, Los Angeles | 2018-01-15 | 2019-01-24 | |
| Guanfacine to Reduce Relapse Risk in Women With Alcohol Use Disorder (AUD) Guanfacine XR 3mgs/daily, Placebo (for guanfacine) - Alcohol Abstinence | Phase 1 / Phase 2 | Completed | Stony Brook University | 32 | 2017-07-12 | 2024-06-05 |
| A Study in Healthy Volunteers and Patients With Chronic Hepatitis B ABI-H0731, Placebo for ABI-H0731, Entecavir - Chronic Hepatitis B | Phase 1 | Completed | Assembly Biosciences | 86 | 2016-11-01 | 2019-04-04 |
| The Role of Endothelin-1 in Sickle Cell Disease Ambrisentan, Placebo - Sickle Cell Anemia | Phase 1 | Completed | Augusta University | 26 | 2015-09-01 | 2020-04-02 |
| Attenuation of D-dimer Using Vorapaxar to Target Inflammatory and Coagulation Endpoints vorapaxar, Placebo - HIV | Phase 1 / Phase 2 | Completed | Kirby Institute | 65 | 2015-09-01 | 2019-03-06 |
| Cycloserine in the Treatment of Sleep Apnea Cycloserine, Placebo - Sleep Apnea Syndromes | Phase 1 | Terminated | University of Manitoba | 18 | 2015-09-01 | 2019-09-17 |
| Papaya Study ID:20140628 Fermented Papaya Preparation (FPP), Sugar Pill - Systemic Inflammation, Aging | Phase 1 | Completed | University of Florida | 30 | 2014-10-01 | 2018-04-09 |
| Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDS) on Acclimatization to High Altitude Ibuprofen, Sugar pill - High Altitude | Phase 1 | Completed | University of California, San Francisco | 20 | 2014-09-01 | 2021-04-06 |
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Substance-Related Disorders (13) · Alcoholism (7) · Cocaine-Related Disorders (6) · Inflammation (4) · Alcohol Drinking (3) · cyclopia sequence (3) · Cognition Disorders (2) · Fatigue (2) · Recurrence (2) · Schizophrenia (2) · Tobacco Use Disorder (2) · Alcohol Abstinence (1) · Alcohol-Related Disorders (1) · Altitude Sickness (1) · Anemia, Sickle Cell (1)
Baylor College of Medicine (13) · Yale University (4) · Massachusetts General Hospital (3) · University of California, San Francisco (3) · M.D. Anderson Cancer Center (2) · University of California, Los Angeles (2) · University of Florida (2) · Vanderbilt University Medical Center (2) · Assembly Biosciences (1) · Augusta University (1) · Bankole Johnson (1) · Boston University (1) · Brown University (1) · Cavion, Inc. (1) · Chelsea Therapeutics (1)
United States (59) · Australia (2) · Canada (1) · Croatia (1) · New Zealand (1) · Sweden (1) · United Kingdom (1)
Richard De La Garza, II, PhD (3) · Mehmet Sofuoglu, M.D.,Ph.D. (2) · Abdullah Kutlar, MD (1) · Adrian Miranda, MD (1) · Ali J. Marian, MD (1) · Alison Oliveto, PhD (1) · Ari J Green, MD (1) · Ari J Green, MD, MCR (1) · Bankole Johnson, DSc,MD.PhD (1) · Brian Day, PhD (1) · Christine A Rabinak, PhD (1) · Chuck Bowden, M.D. (1) · Cyndya Shiabao, M.D. (1) · Cyndya Shibao, MD (1)
PMID 10816186, PMID 12112073, PMID 16324089, PMID 20213818, PMID 21161651, PMID 21419606, PMID 21467190, PMID 22220591, PMID 22319592, PMID 23751236, PMID 23925396, PMID 24393456, PMID 24930359, PMID 26239766, PMID 26508138, PMID 26697176, PMID 28874596, PMID 29540445, PMID 30257802, PMID 30626650, PMID 31161580, PMID 31711752, PMID 36001426, PMID 37254256, PMID 40483726, PMID 41270825
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