10 completed, 6 unknown, 4 recruiting, 2 not yet recruiting. 21 Not applicable, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 21 | Completed 10, Unknown 6, Recruiting 3, Not yet recruiting 2 |
| Phase 2 | 2 | Active not recruiting 1, Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Sham tACS - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Central South University | 99 | 2026-06-01 | 2026-06-16 |
| Dual-site Cross-frequency Coupled Transcranial Electrical Stimulation Modulates Working Memory of Patients With Post-stroke Cognitive Impairment occupational therapy, real tACS, sham tACS - Stroke, Cognition Disorders | Not applicable | Not yet recruiting | Ke Dong, MD | 24 | 2026-05-01 | 2026-05-11 |
| Modulation Effect of tACS on Chronic Low Back Pain Real tACS, Sham tACS - Chronic Low-back Pain | Phase 2 | Recruiting | Massachusetts General Hospital | 80 | 2025-08-25 | 2026-03-16 |
| Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment real tACS, sham tACS - Mild Cognitive Impairment (MCI) | Phase 2 | Active not recruiting | High Point University | 20 | 2025-05-13 | 2026-09-16 |
| TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI) Transcranial Alternating Current Stimulation, Sham tACS - Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Centre for Addiction and Mental Health | 20 | 2025-01-02 | 2026-04-13 |
| Transcranial Alternating Current Stimulation on Patients with Delirium and Critical Illness (DeliTACS) Transcranial alternating current stimulation (TACS), Sham TACS - Delirium | Not applicable | Recruiting | Kuopio University Hospital | 78 | 2024-09-06 | 2024-10-04 |
| Transcranial Alternating Current Stimulation for Treatment-Resistant Depression transcranial alternating current stimulation (tACS), Sham tACS - Treatment-Resistant Depression | Not applicable | Unknown | Xuanwu Hospital, Beijing | 200 | 2024-02-01 | 2024-01-31 |
| 40Hz tACS in Treating Cognitive Function and Modulating Neurophysiology of Patients With Alzheimer's Disease active tACS, sham tACS - Alzheimer Disease | Not applicable | Unknown | Che-Sheng Chu | 48 | 2023-09-01 | 2023-11-13 |
| Modulating Cortical Dynamics of Dual-task Standing in MCI real tACS, sham tACS - Aging, Mild Cognitive Impairment | Not applicable | Unknown | Hebrew SeniorLife | 60 | 2023-03-13 | 2023-03-15 |
| The Effect of Dual-target tACS Combined With Speech Training on Repetition Disorder After Stroke speech training, real tACS, sham tACS - Aphasia | Not applicable | Completed | Ke Dong, MD | 28 | 2023-01-01 | 2026-01-22 |
| tACS Improves Memory in Elders With Subjective Memory Complaints active tACS, sham tACS - Memory Deficits, tACS | Not applicable | Completed | University of Tehran | 16 | 2021-10-01 | 2022-10-10 |
| Effects of Gamma-tACS on EEG Periodic Activity real tACS, sham tACS - Transcranial Alternating Current Stimulation | Not applicable | Completed | IRCCS San Camillo, Venezia, Italy | 34 | 2021-07-20 | 2023-04-12 |
| Mechanism of Action of tACS for the Treatment of MDD tACS, Sham tACS - Major Depressive Disorder, MDD | Not applicable | Completed | University of North Carolina, Chapel Hill | 20 | 2021-06-09 | 2024-09-19 |
| Modulation of Cortical Gamma Synchrony in Stroke real tACS, sham tACS - Stroke | Not applicable | Unknown | IRCCS San Camillo, Venezia, Italy | 220 | 2021-03-23 | 2023-04-26 |
| Alternating Current Stimulation for Essential Tremor transcranial Altering Current Stimulation, Sham tACS - Essential Tremor | Not applicable | Unknown | University of Calgary | 30 | 2020-10-01 | 2020-09-02 |
| Transcranial Alternating Current Stimulation in Post Stroke Aphasia Therapy active 75 Hz transcranial alternating current stimulation, sham transcranial alternating current stimulation - Stroke, Aphasia | Not applicable | Completed | QVITI S.A. | 11 | 2019-12-01 | 2026-04-03 |
| Transcranial Alternating Current Stimulation (tACS) for Cognitive Impairments in Patients With Schizophrenia Active tACS, Sham tACS, Active boosting - Schizophrenia | Not applicable | Unknown | Shanghai Mental Health Center | 90 | 2018-11-01 | 2018-11-28 |
| Effect of Cross Frequency tACS on Cognitive Control Theta-gamma tACS, Delta-beta tACS, Sham tACS - Cognitive Control, Executive Function | Not applicable | Completed | University of North Carolina, Chapel Hill | 26 | 2018-10-07 | 2020-05-18 |
| Single Session of tACS in a Depressive Episode XCSITE100 Stimulator Sham, XCSITE100 Stimulator tACS - Depression, Major Depressive Disorder | Not applicable | Completed | University of North Carolina, Chapel Hill | 84 | 2018-09-19 | 2020-06-04 |
| Transcranial Alternating Current Stimulation in Back Pain- Pilot Sudy XCSITE100 Stimulator Sham, XCSITE100 Stimulator tACS - Chronic Low Back Pain | Not applicable | Completed | University of North Carolina, Chapel Hill | 21 | 2017-09-07 | 2018-12-12 |
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Cognitive Dysfunction (3) · Stroke (3) · Aphasia (2) · Cognition Disorders (2) · Depressive Disorder, Major (2) · Memory Disorders (2) · Alzheimer Disease (1) · Chronic Pain (1) · Delirium (1) · Dementia (1) · Depression (1) · Depressive Disorder, Treatment-Resistant (1) · Essential Tremor (1) · Generalized Anxiety Disorder (1) · Low Back Pain (1)
University of North Carolina, Chapel Hill (6) · IRCCS San Camillo, Venezia, Italy (2) · Ke Dong, MD (2) · Central South University (1) · Centre for Addiction and Mental Health (1) · Che-Sheng Chu (1) · Hebrew SeniorLife (1) · High Point University (1) · Kuopio University Hospital (1) · Massachusetts General Hospital (1) · QVITI S.A. (1) · Shanghai Mental Health Center (1) · University of Calgary (1) · University of Michigan (1) · University of Tehran (1)
United States (9) · China (4) · Italy (2) · Canada (1) · Finland (1) · Iran (1) · Poland (1) · Taiwan (1)
Flavio Frohlich, PhD (4) · Benjamin M Hampstead, Ph.D. (1) · Che-Sheng Chu, MD (1) · Chunbo Li, Ph.D. (1) · David Rubinow, MD (1) · Davide Martino, MD, PhD (1) · Giorgio Arcara (1) · Hongxing Wang, MD & PhD (1) · Karen McCulloch, PhD, DPT (1) · Melike Kahya (1) · Reza Rostami, M.D. (1) · Sahereh Varastegan, MSc (1) · Sanjeev Kumar, MD (1)
PMID 28348136, PMID 30128538, PMID 30268803, PMID 31849514, PMID 33741402
R01MH101547 (3), R01MH111889 (1), R01NS129059 (1)