52 completed, 21 unknown, 17 recruiting, 6 terminated. 108 Phase 2, 23 Phase 3, 14 Phase 1.
Follow Probiotics: new trials by email Literature Review of Probiotics trials Research Report on Probiotics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA) - HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma | Phase 2 | Recruiting | University of California, San Francisco | 90 | 2026-09-04 | 2026-10-29 |
| Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel Placebo, Probiotic - Healthy | Phase 2 | Not yet recruiting | Min-Tze LIONG | 60 | 2026-07-01 | 2026-07-09 |
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| The Bloom Infant Probiotic (BIP) Study Probiotic, Matching placebo - Infant, Newborn, Immunity | Phase 2 | Recruiting | South Australian Health and Medical Research Institute | 360 | 2026-05-25 | 2026-05-28 |
| Probiotics Combined With Targeted Therapy Plus Immunotherapy in Bladder-Preserving Setting for Patients With MIBC Probiotic, Disitamab Vedotin, Toripalimab - Muscle Invasive Bladder Cancer (MIBC) | Phase 2 | Not yet recruiting | chenxu | 146 | 2026-03-26 | 2026-03-17 |
| Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori Infection Vonoparazan, Vitamin D, Probiotic - HELICOBACTER PYLORI INFECTIONS, Helicobacter Infection | Phase 2 | Recruiting | Tanta University | 132 | 2026-02-15 | 2026-09-09 |
| The Effect of Probiotics on Gut Microbiota Changes in Healthy Chinese Adults During Short-Term European Travel: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial Placebo, Probiotic - Healthy Adult | Phase 2 | Not yet recruiting | Min-Tze LIONG | 40 | 2026-02-01 | 2026-02-03 |
| Effects of Probiotics on Respiratory Tract Infections in Children: A Randomized, Placebo-Controlled Interventional Study Probiotic, Placebo Control - URTI | Phase 2 | Enrolling by invitation | Min-Tze LIONG | 120 | 2026-02-01 | 2026-04-02 |
| The Effect of Bifidobacterium Probiotics on Gut Microbiota Changes in Healthy Adults During Short-term Travel Along the Silk Road Probiotic, Placebo - Healthy Adult Volunteer | Phase 2 | Recruiting | Universiti Sains Malaysia | 75 | 2025-10-16 | 2025-12-10 |
| COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY Zinc sulfate, Probiotic lactobacillus rhamnosus GG - Indirect Hyperbilirubinemia, Neonatal | Phase 2 | Recruiting | Quaid-e-Azam Medical College | 110 | 2025-08-07 | 2025-08-05 |
| Effect of Probiotic Intervention on Travel-Related Health Conditions During Short-Term Overseas Travel Probiotic, Placebo - Healthy Adults | Phase 2 | Recruiting | Universiti Sains Malaysia | 46 | 2025-07-31 | 2025-09-17 |
| 5-strain Probiotic Formulation in HR-positive Breast Cancer Receiving Aromatase Inhibitor to Prevent Bone Loss Biospecimen Collection, Bone Mineral Density Test, Questionnaire Administration - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 38 | 2025-07-25 | 2026-08-10 |
| Evaluation of the Clinical Efficacy of Antrrix Probiotics in Improving Recurrent Respiratory Infections in Infants and Young Children Probiotic, Placebo - Recurrent Respiratory Tract Infections | Phase 2 | Recruiting | Min-Tze LIONG | 120 | 2025-05-14 | 2026-04-17 |
| Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC) Probiotics, concurrent Hyperfractionated Radiotherapy, Immunotherapy - Limited Stage Small Cell Lung Cancer | Phase 2 | Recruiting | Fudan University | 60 | 2025-04-25 | 2026-02-11 |
| EXploratory Study on Postprandial Energy Metabolism Probiotic, Placebo - Obesity and Overweight, Moderately Obese | Phase 2 | Recruiting | Lallemand Health Solutions | 66 | 2025-04-07 | 2026-05-28 |
| CMTS4520 for Chronic Diarrhoea in Adults CMTS4520 (dietary fiber and probiotics), Placebo - Diarrhoea | Phase 1 / Phase 2 | Active not recruiting | The Second Hospital of Nanjing Medical University | 100 | 2025-02-20 | 2025-11-18 |
| Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease Probiotic, Placebo - Parkinson Disease, Depression | Phase 2 | Recruiting | University of British Columbia | 60 | 2025-01-20 | 2026-05-08 |
| Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome Fish oil, Probiotics, Prebiotics - Perinatal Depression, PerinatalAnxiety | Phase 2 / Phase 3 | Recruiting | The Canadian College of Naturopathic Medicine | 100 | 2024-08-15 | 2024-08-27 |
| Effect of Probiotics on Infantile Colic Symptoms Probiotic, Placebo - Infantile Colic | Phase 2 | Recruiting | Lallemand Health Solutions | 70 | 2024-08-01 | 2024-08-16 |
| Probiotic For the Improvement of Environmental Enteropathy in Pregnant Women in Senegal Probiotic, Placebo, CapScan® - Environmental Enteric Dysfunction | Phase 2 | Completed | Institut Pasteur de Dakar | 76 | 2024-06-06 | 2026-06-26 |
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Diarrhea (9) · Anxiety Disorders (5) · Irritable Bowel Syndrome (5) · Depression (4) · COVID-19 (3) · Communicable Diseases (3) · Constipation (3) · Fibrosis (3) · Obesity (3) · Overweight (3) · Sleep Initiation and Maintenance Disorders (3) · Asthma (2) · Carcinoma, Non-Small-Cell Lung (2) · Dental Caries (2) · Eczema (2)
Min-Tze LIONG (11) · Lallemand Health Solutions (7) · Danisco (5) · Probi AB (4) · Universitas Indonesia (3) · Universiti Sains Malaysia (3) · National University Hospital, Singapore (2) · PrecisionBiotics Group Ltd. (2) · Sprim Advanced Life Sciences (2) · Universidade de Passo Fundo (2) · University of British Columbia (2) · University of Sao Paulo (2) · Vanderbilt University Medical Center (2) · AC Camargo Cancer Center (1) · AIDS Healthcare Foundation (1)
China (18) · Malaysia (15) · United States (15) · Canada (11) · Brazil (6) · France (4) · Indonesia (4) · Finland (3) · India (3) · Iran (3) · Ireland (3) · South Korea (3) · Chile (2) · Egypt (2) · Germany (2)
Ai Zhou, Ph.D. (2) · Anna Lyra, PhD (2) · Dr Lynette Shek, Consultant (2) · Duane Wombolt, MD (2) · Eileen Murphy, PhD (2) · Jinping Zhang, MD (2) · Jorge Gamonal Aravena, Proffesor (2) · Sampo Lahtinen, PhD (2) · Aihua Zhang, MD. (1) · Ana Balske, MD, PhD (1) · Anneli Tarpila, PhD (1) · Arthur Ouwehand, PhD (1) · Ausama A Malik, MS,MBBS(Mal) (1) · Balgit Chhokar (1)
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K23AA029198 (1), R01HD095158 (1), R03AG040669 (1), U24CA275417 (1)