22 completed, 15 unknown, 2 active not recruiting, 2 not yet recruiting. 43 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 43 | Completed 22, Unknown 15, Active not recruiting 2, Not yet recruiting 2, Enrolling by invitation 1, Recruiting 1 |
Follow Probiotics: new trials by email Literature Review of Probiotics trials Research Report on Probiotics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison of Efficacy of Azithromycin Alone vs Combination of Azithromycin and Probiotics in Management of Mild to Moderate Acne Vulgaris Azithromycin 250 MG Oral Capsule, Azithromycin 250 MG Oral Capsule Along with Oral Probiotics - Acne Vulgaris II or III Degree | Phase 4 | Active not recruiting | Hayatabad Medical Complex | 60 | 2025-10-12 | 2026-02-03 |
| Probiotics in the Prevention of Recurrent Prosthetic Joint Infection of the Hip and Knee Probiotic, Standard of care - Prosthetic-joint Infection, Dysbiosis | Phase 4 | Enrolling by invitation | Boston Medical Center | 152 | 2025-08-15 | 2026-08-26 |
| Impact of Probiotics on Gut Microbiome During Antibiotic Prophylaxis in Elective Orthopedic Surgery Placebo Capsule, Probiotic with Human Milk Oligosaccharides (HMO) - Dysbiosis, Gut -microbiota | Phase 4 | Not yet recruiting | Acibadem Maslak Hospital | 60 | 2025-02-01 | 2025-01-24 |
| A Trial for Comparing Rifaximin, Probiotic and L-ornithine- L Aspartate With Lactulose in Overt Hepatic Encephalopathy. Probiotic plus lactulose, Rifaximin plus lactulose, L-ornithine-L-aspartate plus latulose - Overt Hepatic Encephalopathy | Phase 4 | Completed | Qurratul Ain Jamil | 252 | 2024-12-02 | 2025-06-25 |
| Investigating the Bactericidal Effect of Probiotics on Chromogenic Bacteria in Children An In Vivo and In Vitro Study Probiotic with Prebiotic - Black Stains | Phase 4 | Completed | Ain Shams University | 9 | 2024-11-05 | 2025-04-16 |
| The Effect of Probiotic and Zinc Supplementation in Patients With Gastroesophageal Reflux Disease PPI (proton pump inhibitor), Probiotic, Zinc - Gastro-oesophageal Reflux Disease | Phase 4 | Not yet recruiting | Ain Shams University | 120 | 2024-11-01 | 2024-10-29 |
| The Effect and Mechanism of Xiqing Regulating Intestinal Homeostasis on Drug Efficacy of Chronic Kidney Disease Xiqing, probiotics - CKD, Drug Effect | Phase 4 | Recruiting | Chujin Cao | 120 | 2024-06-07 | 2025-09-19 |
| The Effect of Probiotics on Gut Microbiotain After Helicobacter Pylori Eradication Vonoprazan, Amoxicillin, probiotics - Helicobacter Pylori Infection, Infections | Phase 4 | Unknown | Nanjing First Hospital, Nanjing Medical University | 100 | 2023-06-01 | 2023-02-08 |
| Correlation Between Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy and the Preventive of Probiotics Bifidobacterium Bifidum Oral Capsule, Cisplatin, Carboplatin - Cancer Therapy-related Cardiovascular Toxicity | Phase 4 | Unknown | Peking University Third Hospital | 200 | 2023-02-15 | 2023-02-16 |
| Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (Lactobacillus Reuteri Prodentis) on Porphyromonas Gingivalis. Mouthwash with chlorhexidine and cetylpyridine chloride, Probiotic (Lactobacillus reuteri Prodentis - Periodontal Diseases, Diabetes Mellitus Type 2 | Phase 4 | Active not recruiting | Universidad de Colima | 20 | 2023-01-08 | 2026-03-24 |
| Efficacy And Safety Of Probiatop In The Treatment Of Digestive Symptoms Probiatop, Placebo - Signs and Symptoms, Digestive | Phase 4 | Completed | Azidus Brasil | 150 | 2022-10-20 | 2024-03-25 |
| GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy. Estrogen, dehydroepiandrosterone, Estrogen + probiotics - Vulvovaginal Atrophy, Breast Cancer | Phase 4 | Completed | University Hospital, Ghent | 31 | 2022-03-21 | 2026-08-13 |
| A Study of Probiotics Administration in the Immunotherapy of Urothelial Bladder Carcinoma Live Combined (Bifidobacterium,Lactobacillus and Enterococcus Capsules) - Bladder Urothelial Carcinoma | Phase 4 | Unknown | Tianjin Medical University Second Hospital | 190 | 2022-01-05 | 2022-02-02 |
| Probiotic in Treatment of Adult Patients With Drug-resistant Epilepsy Probiotic - Epilepsy, Treatment | Phase 4 | Completed | Mazandaran University of Medical Sciences | 42 | 2021-04-21 | 2022-01-11 |
| Effect of Probiotic on Gut Microbiome and Bacterial Translocation in Healthy Asian Volunteers Colonic lavage with polyethylene glycol, Probiotic, Antibiotic - Dysbiosis | Phase 4 | Unknown | Changi General Hospital | 32 | 2021-03-10 | 2022-03-22 |
| Probiotic Intervention in PCOS Probiotic, Metformin Hydrochloride, Probiotic Placebo - Polycystic Ovary Syndrome | Phase 4 | Completed | Medical University of Graz | 112 | 2020-11-03 | 2024-03-22 |
| Effect of Live Combined Bifidobacterium and Lactobacillus on Glycemic Control and Other Outcomes in Type 1 Diabetes live combined Bifidobacterium and Lactobacillus Tablets - Type 1 Diabetes Mellitus, Probiotics | Phase 4 | Completed | Shenzhen People's Hospital | 60 | 2020-09-01 | 2022-08-09 |
| Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children probiotics, conventional medical treatment - Rhinitis, Allergic, Asthma | Phase 4 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 200 | 2020-03-01 | 2021-06-24 |
| Synbiotics Interventions for Managing Cirrhosis and Its Complications Entecavir 0.5 mg, A 10-g packet of lactulose oral solution and three capsules of probiotics, A 10-g packet of glucose oral solution and three capsules of starch - Cirrhosis, Liver, Metagonimiasis | Phase 4 | Completed | First Affiliated Hospital of Zhejiang University | 120 | 2019-11-24 | 2023-01-18 |
| Probiotics as Adjuvant Treatment for Bacterial Vaginosis "Probiotics" and "Metronidazole", Metronidazole Vaginal - Bacterial Vaginosis | Phase 4 | Completed | Peking University Shenzhen Hospital | 126 | 2019-03-26 | 2021-07-09 |
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Diarrhea (3) · Dysbiosis (3) · Infections (3) · Irritable Bowel Syndrome (3) · Colitis, Ulcerative (2) · Crohn Disease (2) · Dermatitis, Atopic (2) · Diabetes Mellitus, Type 1 (2) · Liver Cirrhosis (2) · Liver Diseases, Alcoholic (2) · Surgical Wound Infection (2) · Anastomotic Leak (1) · Asthma (1) · Breast Neoplasms (1) · Communicable Diseases (1)
Ain Shams University (2) · Chuncheon Sacred Heart Hospital (2) · The Baruch Padeh Medical Center, Poriya (2) · Acibadem Maslak Hospital (1) · American Academy of Family Physicians (1) · Asian Institute of Gastroenterology, India (1) · Azidus Brasil (1) · Azienda Ospedaliero Universitaria Maggiore della Carita (1) · Boston Medical Center (1) · Cairo University (1) · Casa Espirita Terra de Ismael (1) · Chang Gung Memorial Hospital (1) · Changi General Hospital (1) · China Medical University Hospital (1) · Chujin Cao (1)
China (8) · United States (4) · India (3) · Brazil (2) · Egypt (2) · Israel (2) · Pakistan (2) · South Korea (2) · Taiwan (2) · Thailand (2) · Turkey (Türkiye) (2) · Austria (1) · Belgium (1) · Botswana (1) · Iran (1)
Agnieszka Szypowska, Assoc. Prof. (1) · Ami Sperber, MD (1) · Arnon Blum, MD (1) · Ayesha Abdeen, MD (1) · Ayesha Naeem (1) · Barbara Obermayer-Pietsch, Prof. MD (1) · Bikash Medhi, MD (1) · Chien-Chang Chen, MD (1) · Dr. Nageshwar Reddy, DM (1) · Dr. Nitesh Pratap, DM (1) · Emanuele Chisari, Dr., Ph.D. (1) · Ener C Dinleyici, MD (1) · Evangelos Giamarellos-Bourboulis, MD, PhD (1) · Gagandeep Kang, MD, PhD (1)
PMID 16317068, PMID 18503496, PMID 18820210, PMID 18843118, PMID 19225551, PMID 19625695, PMID 20463897, PMID 21364875, PMID 21646390, PMID 22043294, PMID 22315304, PMID 22946851, PMID 23176716, PMID 23274889, PMID 23314185, PMID 23433344, PMID 23934614, PMID 24357209, PMID 24448554, PMID 25894405, PMID 26302024, PMID 29025837, PMID 33771763, PMID 34229263, PMID 37062834, PMID 37180228, PMID 37870148, PMID 41272855, PMID 9004335