34 completed, 11 unknown, 5 terminated, 4 recruiting. 57 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 57 | Completed 34, Unknown 11, Terminated 5, Recruiting 4, Enrolling by invitation 1, Not yet recruiting 1, Withdrawn 1 |
Follow Phenylephrine: new trials by email Literature Review of Phenylephrine trials Research Report on Phenylephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| OB VEGA-Phenylephrine vs Norepinephrine Outcomes Phenylephrine, Norepinephrine - Hypotension During Surgery, Cesarean Birth | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 1500 | 2027-01-01 | 2026-10-28 |
| Comparison of Norepinehrine Versus Phenylepherine Infusion for Prevention of Post-spinal Hypotension Norepinephrine, Phenylephrine - Patients Undergoing Orthopedic Hip Surgery Under Spinal Anesthesia, Orthopedic Hip Sugery in Eldely Patients | Phase 4 | Recruiting | Sohag University | 62 | 2026-05-22 | 2026-06-23 |
| The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery Norepinephrine, Phenylephrine - Anesthesia, Surgery With General Anesthesia | Phase 4 | Recruiting | University of California, San Francisco | 18000 | 2025-04-01 | 2026-05-26 |
| Norepinephrine vs. Phenylephrine for Hypotension in Low-Dose Spinal Anesthesia for Cesarean Delivery Norepinephrine, Phenylephrine - Anesthesia, Spinal | Phase 4 | Completed | Tam Anh Research Institute | 100 | 2024-06-06 | 2026-01-21 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Cerebral Flow-metabolism Coupling During Adult Surgery Propofol, Sevoflurane, Ephedrine - Anesthesia | Phase 4 | Unknown | Jason Chui | 80 | 2023-10-03 | 2023-10-18 |
| The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance Epinephrin, Norepinephrine, Phenylephrine - Cardiac Output, Low, Cardiac Output, High | Phase 4 | Unknown | Medical University of Vienna | 225 | 2022-09-01 | 2022-10-19 |
| Hemodynamics During Induction of General Anesthesia After Prophylactic Ephedrine, Phenylephrine or Norepinephrine. Ephedrine, Phenylephrine, Norepinephrine - Hemodynamic Instability, Anesthesia, General | Phase 4 | Completed | Helse Fonna | 128 | 2022-03-15 | 2024-10-04 |
| Effect of Intracameral Phenylephrine/Ketorolac on Intraoperative Pain 1% preservative-free lidocaine, Phenylephrine 1.0%/ Ketorolac 0.3% - Pain Reduction | Phase 4 | Withdrawn | University of Florida | 2022-02-01 | 2022-06-13 | |
| Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery metaraminol, Phenylephrine, Norepinephrine - Cesarean Section Complications | Phase 4 | Completed | Xuzhou Medical University | 78 | 2021-10-10 | 2021-12-30 |
| The GUARDIAN Trial - Vasopressor Sub-Study Routine Blood Pressure Management, Tight Blood Pressure Management, Phenylephrine - Blood Pressure | Phase 4 | Enrolling by invitation | The University of Texas Health Science Center, Houston | 6254 | 2021-07-25 | 2025-08-29 |
| Norepinephrine vs Phenylephrine During General Anesthesia Norepinephrine, Phenylephrine - Anesthesia, Surgery | Phase 4 | Completed | University of California, San Francisco | 3626 | 2021-07-01 | 2026-09-01 |
| Hemodynamic Optimization of Cerebral Perfusion After Endovascular Therapy in Patients With Acute Ischemic Stroke Adjusted medication - Acute Ischemic Stroke | Phase 4 | Unknown | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 814 | 2021-06-01 | 2023-03-16 |
| Low Dose Vasopressin vs Phenylephrine in Cardiac Surgery Vasopressin, Phenylephrine - Acute Kidney Injury | Phase 4 | Unknown | Thomas Jefferson University | 300 | 2020-10-15 | 2024-03-29 |
| Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures Phenylephrine, Combination of PEEP and positioning - Ultrasonography, Renal, Cardiac Surgery | Phase 4 | Completed | Aarhus University Hospital | 30 | 2020-05-25 | 2021-08-06 |
| Efficacy and Safety of Mydriatic Microdrops Compared With Standard Drops for Retinopathy of Prematurity (ROP) Screening: a Pilot Randomized Clinical Trial Microdrop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 6-7 μL)], Standard drop administration [phenylephrine 1.67% + tropicamide 0.33% (drop volume: 28-34 μL)] - Retinopathy of Prematurity | Phase 4 | Completed | Aristotle University Of Thessaloniki | 25 | 2020-03-24 | 2022-04-04 |
| Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly Norepinephrine, phenylephrine - Spinal Induced Hypotension, Elderly | Phase 4 | Completed | Kasr El Aini Hospital | 62 | 2020-01-01 | 2021-09-01 |
| Intramuscular Phenylephrine HCL for Prevention of Spinal Anesthesia Induced Hypotension Phenylephrine Hydrochloride 4 mg, Phenylephrine Hydrochloride 8 mg - Hypotension, Anesthesia | Phase 4 | Completed | Rehman Medical Institute - RMI | 60 | 2020-01-01 | 2022-04-27 |
| Influence of Continuous Administration of Phenylephrine Versus Dobutamine on Spinal Oxygen Saturation, Measured With Near-infrared Spectroscopy (NIRS). Phenylephrine, Dobutamine - Nfuence of Vasoactive Medication on Spinal Oxygenation | Phase 4 | Completed | University Hospital, Ghent | 36 | 2019-07-04 | 2022-12-12 |
| Effect of Phenylephrine Versus Norepinephrine on Venous Return Phenylephrine, Norepinephrine - Arterial Hypotension | Phase 4 | Unknown | Algemeen Ziekenhuis Maria Middelares | 40 | 2019-06-01 | 2019-10-11 |
Showing 20 of 57. Sign in to see all of them.
Hypotension (17) · Mydriasis (4) · Acute Kidney Injury (2) · Cardiac Output, Low (2) · Diabetes Insipidus (2) · Retinopathy of Prematurity (2) · Shock (2) · Shock, Septic (2) · Tachycardia (2) · Aneurysm (1) · Arrhythmias, Cardiac (1) · Atrial Fibrillation (1) · Brain Ischemia (1) · Brain Neoplasms (1) · Cardiac Output, High (1)
Cairo University (4) · Algemeen Ziekenhuis Maria Middelares (2) · Khon Kaen University (2) · Medical University of Vienna (2) · University Hospital, Ghent (2) · University Tunis El Manar (2) · University of California, San Francisco (2) · Aarhus University Hospital (1) · American University of Beirut Medical Center (1) · Aristotle University Of Thessaloniki (1) · Central Hospital, Nancy, France (1) · Centre Hospitalier Régional d'Orléans (1) · Cukurova University (1) · Dar El Oyoun Hospital (1) · Denver Health and Hospital Authority (1)
United States (13) · Egypt (7) · Canada (5) · Belgium (4) · Denmark (3) · Austria (2) · China (2) · France (2) · Greece (2) · Norway (2) · South Korea (2) · Thailand (2) · Tunisia (2) · United Kingdom (2) · Colombia (1)
Ahmed Mukhtar, Professor (3) · Alain F Kalmar, MD, PhD (2) · Yosanan Yospaiboon, M.D. (2) · Ahmed M Mukhtar, Professor (1) · Allison Janda, MD (1) · Ashraf S Habib, MD (1) · B. S Segal, MD (1) · Caroline Vanpeteghem (1) · Caroline Vanpeteghem, MD (1) · Cesar Ormeno, MD (1) · Chandra Ramamoorthy, MD (1) · Charles Lin, MD (1)
PMID 18946298, PMID 20462091, PMID 22368443, PMID 24624090, PMID 24920942, PMID 25635593, PMID 27144689, PMID 27733286, PMID 29090733, PMID 29151054, PMID 29406176, PMID 29945801, PMID 30335625, PMID 30389535, PMID 30639574, PMID 30687737, PMID 31008870, PMID 31046075, PMID 31165350, PMID 32581577, PMID 32619039, PMID 33109924, PMID 33267787, PMID 33483132, PMID 34654903, PMID 35230558, PMID 36279409, PMID 36925330, PMID 37186094, PMID 38242802, PMID 39208776, PMID 41144827, PMID 41701325, PMID 42258192, PMID 42479502
2019 (1), R01DK139484 (1), UL1RR024975-01 (1), UL1TR000445-06 (1)