17 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 28 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Completed 17, Unknown 3, Not yet recruiting 2, Recruiting 2, Terminated 2, Suspended 1, Withdrawn 1 |
| Phase 2 | 7 | Completed 4, Not yet recruiting 1, Recruiting 1, Suspended 1 |
Follow Phenylephrine: new trials by email Literature Review of Phenylephrine trials Research Report on Phenylephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Study of DA-001 as a Treatment for Hair Shedding Reduction and Hair Re-Growth DA-001, Placebo, Phenylephrine - Telogen Effluvium, Female Pattern Hair Loss | Phase 2 / Phase 3 | Not yet recruiting | Applied Biology, Inc. | 1120 | 2026-05-01 | 2026-04-13 |
| Phase 3 Clinical Trial to Evaluate Paracetamol /Fexofenadine /Phenylephrine in Flu and Cold Treatment Experimental drug (paracetamol 500mg / fexofenadine 60mg / phenylephrine 20mg), Placebo - Cold, Flu Symptom | Phase 3 | Completed | Eurofarma Laboratorios S.A. | 567 | 2025-03-26 | 2026-10-26 |
| CompARing Between CO2 Phenylephrine and Phenylephrine Only Treatment in Patients With proGrEssing Cerebral infarctioN carbogen with or without phenyleprhine, phenylephrine - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Yonsei University | 40 | 2025-02-01 | 2025-01-20 |
| Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2) BP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil) - Acute Ischemic Stroke | Phase 3 | Recruiting | Yonsei University | 176 | 2024-10-01 | 2026-02-13 |
| Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold Acetylcysteine, Paracetamol, Phenylephrine - Common Cold | Phase 3 | Withdrawn | Sandoz | 2024-09-20 | 2024-09-26 | |
| Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia Noradrenalin, Phenylephrine - Hypotension | Phase 2 / Phase 3 | Recruiting | University of Aarhus | 32 | 2023-12-20 | 2026-03-19 |
| Comparative Analytical Study of Intravenous Bolus Dose of Mephentermine and Phenylephrine for Hemodynamic Stability During Elective Cesarean Section Under Spinal Anesthesia at KIST Medical College and Teaching Hospital Intravenous bolus dose of Mephentermine and mephentermine, intravenous bolus dose of phenylephrine 50 mcg - Hemodynamic Stability | Phase 3 | Completed | KIST Medical and Teaching Hospital | 42 | 2023-03-23 | 2024-10-09 |
| Clinical Trial of Anusol Ointment for Symptom Relief in Patients With Haemorrhoids Anusol, Relief [Name], Placebo - Hemorrhoids | Phase 3 | Completed | Church & Dwight Company, Inc. | 66 | 2021-11-25 | 2022-08-15 |
| Comparing Between CO2 and Phenylephrine Treatment in Patients With Progressive Lacunar Infarction (CARBOGEN Study) carbogen, phenylephrine - Acute Ischemic Stroke | Phase 3 | Terminated | Yonsei University | 3 | 2021-04-05 | 2025-01-14 |
| Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension Norepinephrine, Phenylephrine - Spinal Induced-hypotension | Phase 3 | Completed | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 80 | 2019-11-10 | 2021-03-09 |
| Norepinephrine and Phenylephrine, Which Better for Elderly? norepinephrine, Phenylephrine - Hypotension | Phase 3 | Unknown | The Second Affiliated Hospital of Dalian Medical University | 100 | 2019-10-06 | 2019-10-08 |
| The Phenylephrine vs. Norepinephrine Infusion Undergoing Cesarean Section Norepinephrine, Phenylephrine, Ringer's Solution - Cesarean Section Complications | Phase 2 / Phase 3 | Completed | China International Neuroscience Institution | 238 | 2019-02-20 | 2020-02-10 |
| Safety and Efficacy of Phenylephrine 2.5%-Tropicamide 1% Microdose Ophthalmic Solution for Pupil Dilation Tropicamide 1%-Phenylephrine 2.5% ophthalmic solution (TR/PE), Tropicamide 1% ophthalmic solution (TR), Phenylephrine 2.5% ophthalmic solution (PE) - Mydriasis | Phase 3 | Completed | Eyenovia Inc. | 70 | 2018-11-15 | 2022-03-18 |
| Ephedrine and Phenylephrine for Spinal Hypotension Phenylephrine, Ephedrine - Spinal Hypotension | Phase 2 / Phase 3 | Completed | Assiut University | 60 | 2017-02-07 | 2020-10-27 |
| Phenylephrine or Norepinephrine for a Better Hemodynamic Stability phenylephrine, Norepinephrine - Hypotension, Fluid Therapy | Phase 3 | Completed | The Second Affiliated Hospital of Dalian Medical University | 40 | 2016-09-01 | 2018-01-23 |
| Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly Hemodynamic target, Phenylephrine, Intravenous fluids - Post-operative Cognitive Dysfunction | Phase 2 / Phase 3 | Suspended | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 1812 | 2014-10-01 | 2018-04-13 |
| Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu Paracetamol (500 mg)/dimethindene maleate (1 mg)/ phenylephrine hydrochloride (10 mg) tablets, Paracetamol (500 mg) tablets - Upper Respiratory Tract Infection, Nasal Congestion | Phase 3 | Completed | Novartis | 341 | 2013-07-01 | 2017-03-03 |
| A Novel Closed-loop Integrated System for the Maintenance of Haemodynamic Stability vasopressor delivery automated system, phenylephrine, ephedrine - Hypotension | Phase 2 / Phase 3 | Completed | KK Women's and Children's Hospital | 252 | 2013-05-01 | 2026-08-07 |
| Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION) Phenylephrine - Stroke, Acute, Progressing Stroke | Phase 3 | Unknown | Samsung Medical Center | 170 | 2012-06-01 | 2017-04-26 |
| Warming Sensation Intensity and Acceptability of the Flavour, Local Tolerability of Paracetamol 500 mg + Phenylephrine 10mg + Guaifenesin 200 mg Syrup in Patients Suffering a Upper Respiratory Tract Infection (URTI) IFF flavor 316 282, Paracetamol , Phenylephrine, Guaifenesin - Upper Respiratory Infections | Phase 3 | Completed | Novartis | 51 | 2012-03-01 | 2013-11-11 |
Showing 20 of 28. Sign in to see all of them.
Hypotension (5) · Common Cold (4) · Ischemic Stroke (4) · Mydriasis (3) · Rhinitis, Allergic, Seasonal (3) · Respiratory Tract Infections (2) · Stroke, Lacunar (2) · Alopecia (1) · Cognitive Dysfunction (1) · Delirium (1) · Disease Progression (1) · Eye Diseases (1) · Hemorrhoids (1) · Nasal Obstruction (1) · Premature Birth (1)
Bayer (3) · Yonsei University (3) · KK Women's and Children's Hospital (2) · Novartis (2) · The Second Affiliated Hospital of Dalian Medical University (2) · Applied Biology, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · China International Neuroscience Institution (1) · Church & Dwight Company, Inc. (1) · Eurofarma Laboratorios S.A. (1) · Eyenovia Inc. (1) · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico (1) · Hospital de Clinicas de Porto Alegre (1) · KIST Medical and Teaching Hospital (1)
South Korea (4) · Brazil (3) · China (2) · Nepal (2) · Armenia (1) · Canada (1) · Denmark (1) · Egypt (1) · France (1) · Italy (1) · Singapore (1) · Thailand (1) · United States (1)
Alessandro Santini, MD (1) · Andy Goren, MD (1) · Annahita Ghassemi, PhD (1) · Antonio Pesenti, MD (1) · Ban L Sng, FANZCA (1) · Ban Leong Sng, FANZCA (1) · Dr. Smriti Koirala, MD (1) · Hyo Suk Nam, MD, PhD (1) · Luciano Gattinoni, MD, FRCP (1) · Mads Rasmussen, MD, PhD (1) · Michael Quintel, MD, PhD (1) · Oh Young Bang, MD (1) · Thomas Langer, MD (1)
PMID 17205877, PMID 19230461, PMID 24256483, PMID 26560899, PMID 29373334, PMID 30243062, PMID 31645472, PMID 32894044, PMID 34101716, PMID 40132839