6 completed, 1 not yet recruiting. 7 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 6, Not yet recruiting 1 |
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
Follow Nicotine Chewing Gum: new trials by email Literature Review of Nicotine Chewing Gum trials Research Report on Nicotine Chewing Gum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | Xianhui Wang | 20 | 2026-11-01 | 2026-10-21 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes VLN menthol cigarettes (A), Usual Brand Menthol Cigarettes (B), Nicotine gum (C) - Tobacco Use | Phase 1 | Completed | 22nd Century Group, Inc. | 55 | 2018-05-01 | 2020-03-25 |
| Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C) - Tobacco Use | Phase 1 | Completed | 22nd Century Group, Inc. | 66 | 2018-04-13 | 2020-03-26 |
| A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers Oromucosal Nicotine Spray (ONS), Nicotine Gum, Cigarette - Healthy | Phase 1 | Completed | Janssen Pharmaceutical K.K. | 24 | 2017-12-22 | 2025-02-03 |
| Comparison of Pharmacokinetic Profiles of 3 New Nicotine Gum Formulations With a Reference Gum Nicotine gum - Smoking Cessation | Phase 1 | Completed | Fertin Pharma A/S | 15 | 2014-04-01 | 2015-02-05 |
| 4 mg Nicotine Polacrilex Gum and Swedish Portion Snus Nicotine - Healthy Subjects, Smokers | Phase 1 / Phase 2 | Completed | Contract Research Organization el AB | 15 | 2006-03-01 | 2010-08-16 |
Tinnitus (2) · Tobacco Use (2) · Smoking Cessation (1)
22nd Century Group, Inc. (2) · Contract Research Organization el AB (1) · Fertin Pharma A/S (1) · Janssen Pharmaceutical K.K. (1) · San Diego State University (1) · Xianhui Wang (1)
United States (4) · Japan (1) · Sweden (1)
Debra Kelsh, MD (2) · Xianhui Wang (2) · Erik Lunell, MD, PhD (1) · Tejas Acharya, M.D. (1)