11 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 15 Phase 2, 4 Phase 3, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 11, Recruiting 2, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 4 | Completed 3, Recruiting 1 |
| Phase 1 | 3 | Completed 2, Not yet recruiting 1 |
Follow Nicotine Chewing Gum: new trials by email Literature Review of Nicotine Chewing Gum trials Research Report on Nicotine Chewing Gum
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Not yet recruiting | San Diego State University | 20 | 2026-11-01 | 2026-11-06 |
| Acute Nicotine Gum and Tinnitus Loudness in Non-Smoking Adults Nicotine polacrilex gum 4 mg, Placebo gum - Tinnitus, Chronic Subjective Tinnitus | Phase 1 / Phase 2 | Completed | San Diego State University | 29 | 2026-03-25 | 2026-10-16 |
| Evaluating Smoking Cessation Interventions for PWH in South Africa Varenicline, Nicotine patch, Nicotine gum - Smoking Cessation, HIV | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 660 | 2023-11-27 | 2026-10-19 |
| Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD active repetitive transcranial magnetic stimulation, sham repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation - Tobacco Use Disorder | Phase 2 | Recruiting | VA Office of Research and Development | 50 | 2023-10-31 | 2026-02-18 |
| Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment Varenicline, Bupropion, Long-acting nicotine replacement therapy - Smoking Cessation, Cancer, Treatment-Related | Phase 2 | Completed | Joseph Valentino, MD | 126 | 2021-01-12 | 2026-11-05 |
| Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO) Varenicline, Oral Nicotine Replacement Therapy (NRT), Medication Reminders - Smoking Cessation | Phase 2 | Terminated | University of Oklahoma | 34 | 2020-01-07 | 2024-02-06 |
| CPT and Smoking Cessation Cognitive Processing Therapy (CPT), Bupropion, nicotine replacement therapy (NRT) - Stress Disorders, Post-Traumatic, Smoking | Phase 2 / Phase 3 | Completed | VA Office of Research and Development | 69 | 2013-12-11 | 2018-09-11 |
| Tailored Tobacco Quitline for Rural Veterans Nicotine replacement therapy - transdermal nicotine patch, Tailored behavioral intervention, Tobacco quit line referral - Cigarette Smoking | Phase 2 | Completed | Iowa City Veterans Affairs Medical Center | 63 | 2012-06-01 | 2019-08-02 |
| Smoking Habits and Smoking Cessation in Young Adults varenicline, Nicotine cutaneous patch 15mg/16h, Nicotine cutaneous patch 10mg/16h - Smoking Cessation, Smoking | Phase 2 / Phase 3 | Completed | Tuula Toljamo | 300 | 2012-05-01 | 2017-06-05 |
| Varenicline in Combination With Nicotine Replacement Therapy for Smoking Cessation Varenicline, Nicotine Patch, Varenicline and Placebo Patch - Tobacco Dependence | Phase 2 | Completed | University of Stellenbosch | 446 | 2011-04-01 | 2014-03-26 |
| Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine Oral tobacco, Nicotine Gum - Tobacco Use Disorder | Phase 2 | Completed | University of Minnesota | 391 | 2010-04-01 | 2017-12-06 |
| Health Effects of SLT, Cigarette Smoking, and New Tobacco Products Nicotine gum and lozenge, Taboka, Camel Snus - Nicotine Dependence | Phase 2 | Completed | University of Minnesota | 130 | 2007-01-01 | 2019-11-01 |
| 4 mg Nicotine Polacrilex Gum and Swedish Portion Snus Nicotine - Healthy Subjects, Smokers | Phase 1 / Phase 2 | Completed | Contract Research Organization el AB | 15 | 2006-03-01 | 2010-08-16 |
| Effectiveness of Various Smoking Cessation Therapies in Reducing Smoking in Adolescents - 1 Nicotine Replacement Therapies, Nicotine patch, Folic Acid - Smoking Cessation, Tobacco Use Disorder | Phase 2 | Completed | National Institute on Drug Abuse (NIDA) | 128 | 2002-04-01 | 2017-01-10 |
| Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence Nicotine Patch, Nicotine Gum - Tobacco Dependence | Phase 2 / Phase 3 | Completed | National Institute on Drug Abuse (NIDA) | 157 | 1999-08-01 | 2017-01-12 |
Smoking Cessation (8) · Tobacco Use Disorder (7) · Smoking (4) · Tinnitus (2) · Alcohol Drinking (1) · Behavior, Addictive (1) · Body Weight (1) · Cigarette Smoking (1) · Depression (1) · Habits (1) · Harm Reduction (1) · Neoplasms, Second Primary (1) · Stress Disorders, Post-Traumatic (1) · Tobacco Use Cessation (1)
National Institute on Drug Abuse (NIDA) (2) · San Diego State University (2) · University of Minnesota (2) · VA Office of Research and Development (2) · Contract Research Organization el AB (1) · Iowa City Veterans Affairs Medical Center (1) · Johns Hopkins University (1) · Joseph Valentino, MD (1) · Tuula Toljamo (1) · University of Oklahoma (1) · University of Stellenbosch (1)
United States (11) · South Africa (2) · Finland (1) · Sweden (1)
Dorothy Hatsukami, Ph.D. (2) · Xianhui Wang (2) · Darla Kendzor, PhD (1) · Dorothy Hatsukami, PHD (1) · Elvis M Irusen, MBChB, FCP, PhD (1) · Eric A Dedert, PhD (1) · Eric T. Moolchan, M.D. (1) · Erik Lunell, MD, PhD (1) · Jonathan E Golub, PhD MPH (1) · Jonathan R Young, MD (1) · Joseph Valentino, MD (1) · Mark VanderWeg, PhD (1) · Neil Martison (1) · Pentti Nieminen, PhD (1)
PMID 37142273, PMID 25005652, PMID 27535024, PMID 30664539, PMID 34611902, PMID 37889541, PMID 40543725
P50DA013333 (1), R01CA135884 (1), U01CA261626 (1)