8 completed, 4 unknown, 3 terminated, 1 active not recruiting. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 8, Unknown 4, Terminated 3, Active not recruiting 1, Recruiting 1 |
Follow NAC: new trials by email Literature Review of NAC trials Research Report on NAC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement N acetyl cysteine, normal saline - Oxidative Stress, Liver Dysfunction | Phase 4 | Completed | Kasr El Aini Hospital | 54 | 2024-06-30 | 2025-08-29 |
| Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair Ascorbic acid, N-acetyl cysteine, placebo - Rotator Cuff Tears | Phase 4 | Unknown | Mahidol University | 110 | 2024-05-01 | 2024-04-25 |
| The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM) n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System - Asthma, COPD | Phase 4 | Active not recruiting | University of California, San Francisco | 40 | 2024-04-09 | 2026-08-13 |
| Efficacy of Intravenous N-Acetylcysteine in Preventing Linezolid-Induced Thrombocytopenia in Critically Ill Patients N acetyl cysteine, Placebo - Linezolid, Antioxidant | Phase 4 | Completed | Helwan University | 250 | 2023-08-01 | 2025-07-14 |
| A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder N-acetyl cysteine, Placebo - Alcohol Use Disorder (AUD) | Phase 4 | Recruiting | University of Sydney | 280 | 2023-02-16 | 2023-03-16 |
| N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use N-Acetyl cysteine, Placebo comparator, Cognitive behavioral therapy (CBT) - Cannabis Use, Tobacco Use Disorder | Phase 4 | Completed | Ellen Herbst | 41 | 2021-08-25 | 2026-08-11 |
| The Effect of NAC on Lung Function and CT Mucus Score n-acetylcystine + albuterol, 0.9% saline + albuterol - Asthma | Phase 4 | Terminated | University of California, San Francisco | 4 | 2019-02-20 | 2026-06-11 |
| Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement N Acetyl Cysteine, Placebos - Surgery--Complications, Cardiac Valve Disease | Phase 4 | Unknown | University of Sao Paulo General Hospital | 154 | 2018-03-15 | 2018-03-05 |
| Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use N-Acetyl Cysteine - Bronchiolitis Acute | Phase 4 | Unknown | Carilion Clinic | 106 | 2018-02-01 | 2019-09-26 |
| Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine Acetyl cysteine, Placebos - Postoperative Pain | Phase 4 | Completed | Radboud University Medical Center | 60 | 2017-10-20 | 2019-08-13 |
| Effect of N-acetylcysteine on Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial. Alcohol N-acetylcysteine, Alcohol Placebo, Cocaine N-acetylcysteine - Cocaine Addiction, Alcohol Addiction | Phase 4 | Unknown | Hospital de Clinicas de Porto Alegre | 100 | 2017-01-01 | 2017-01-24 |
| Clinical Trial of NAC in Asthma n-acetylcystine, 0.9% saline - Asthma | Phase 4 | Terminated | University of California, San Francisco | 1 | 2016-03-01 | 2019-08-20 |
| NAC, NaHCO3 and NS Prophylaxis for CTPA in the ED on Suspicion of PE: A Randomized Controlled Trial NAC, NaHCO3, Normal Saline - Radiographic Contrast Agent Nephropathy, Pulmonary Embolism | Phase 4 | Completed | Karadeniz Technical University | 231 | 2014-02-01 | 2015-06-26 |
| N-acetyl Cysteine for Ovulation Induction in Clomiphene Citrate Resistant Polycystic Ovary Syndrome N-Acetyl cysteine, laparoscopic ovarian drilling - Polycystic Ovary Syndrome | Phase 4 | Completed | Assiut University | 70 | 2012-01-01 | 2014-09-12 |
| Effects of N-acetylcysteine on Low T3 Syndrome N-acetylcysteine - Acute Myocardial Infarction, Euthyroid Sick Syndrome | Phase 4 | Completed | Federal University of Rio Grande do Sul | 83 | 2011-11-01 | 2015-03-31 |
| Clomiphene Plus N-acetyl Cysteine for Induction of Ovulation in Newly Diagnosed Pcos. NAC - PCOS | Phase 4 | Completed | Woman's Health University Hospital, Egypt | 200 | 2011-01-01 | 2020-08-12 |
| Induced Changes in Ventilatory Responsiveness and Altitude Exposure NAC, Placebo - Effects of High Altitude, Hypoxia | Phase 4 | Terminated | United States Army Research Institute of Environmental Medicine | 21 | 2010-11-01 | 2020-04-30 |
Asthma (3) · Alcoholism (2) · Substance-Related Disorders (2) · Acute Kidney Injury (1) · Altitude Sickness (1) · Behavior, Addictive (1) · Cocaine-Related Disorders (1) · Critical Illness (1) · Euthyroid Sick Syndromes (1) · Heart Valve Diseases (1) · Hypoxia (1) · Insulin Resistance (1) · Liver Diseases (1) · Marijuana Abuse (1) · Myocardial Ischemia (1)
University of California, San Francisco (3) · Assiut University (1) · Carilion Clinic (1) · Ellen Herbst (1) · Federal University of Rio Grande do Sul (1) · Helwan University (1) · Hospital de Clinicas de Porto Alegre (1) · Karadeniz Technical University (1) · Kasr El Aini Hospital (1) · Mahidol University (1) · Radboud University Medical Center (1) · United States Army Research Institute of Environmental Medicine (1) · University of Sao Paulo General Hospital (1) · University of Sydney (1) · Woman's Health University Hospital, Egypt (1)
United States (6) · Brazil (3) · Egypt (2) · Australia (1) · Netherlands (1) · Turkey (Türkiye) (1)
Alaa M Ismail, M D (1) · Charles S Fulco, ScD (1) · Ellen Herbst, MD (1) · Flavio Pechansky, PhD (1) · John Fahy, M.D, M.Sc. (1) · John Fahy, MD, MS (1) · John V Fahy, MD, MSc (1) · Josi Vidart (1) · Kris Vissers, MD, PhD (1) · Lisia von Diemen, PhD (1) · Madeline Martinez Rivas, PhD (1) · Mohamed Abdeltawab, Pharm D (1) · Rahul Pandey, MD (1)
PMID 16363316, PMID 25148231, PMID 27411777, PMID 33725178, PMID 34446544, PMID 37271412, PMID 40921646, PMID 41577060, PMID 9783643
R01HL080414 (1)