75 completed, 13 recruiting, 13 unknown, 9 terminated. 52 Phase 2, 25 Phase 1, 20 Not applicable, 19 Phase 3, 17 Phase 4.
Follow NAC: new trials by email Literature Review of NAC trials Research Report on NAC
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| N-Acetylcysteine in the Management of Spontaneous Bacterial Peritonitis Placebo, NAC - SBP - Spontaneous Bacterial Peritonitis | Phase 1 / Phase 2 | Recruiting | Tanta University | 60 | 2026-10-25 | 2026-10-30 |
| NAC-REPAIR for Post-surgical Pain NAC, NAC 0mg/day (Placebo) - Carpal Tunnel Surgery, Trigger Finger Disorder | Phase 2 | Not yet recruiting | University of Arizona | 80 | 2026-10-15 | 2026-07-17 |
| Tolerability of Enteral NAC in Infants N-Acetylcysteine - Biliary Atresia | Phase 1 | Not yet recruiting | Sanjiv Harpavat | 12 | 2026-10-01 | 2026-03-04 |
| Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure N Acetyl Cysteine, Standard supportive care - Acute Liver Failure | Not applicable | Recruiting | King Edward Medical University | 62 | 2026-07-16 | 2026-08-19 |
| Effect of NAC on Preventing Chemo-Related Cognitive Impairments in Ovarian Ca Pts Treated W/ PBT N-Acetyl-Cysteine, Placebo - Ovarian Cancer, Cognitive Impairment | Phase 1 / Phase 2 | Recruiting | University of California, Irvine | 102 | 2026-05-21 | 2026-07-17 |
| Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS) Acetylcysteine, EH301, Riluzole - Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | Recruiting | Biogipuzkoa Health Research Institute | 90 | 2025-11-25 | 2026-02-17 |
| Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy Neoadjuvant Chemotherapy, Radical Cystectomy - Muscle Invasive Bladder Cancer | Not applicable | Recruiting | Assiut University | 76 | 2025-09-01 | 2025-10-02 |
| The Combined Effect of N-Acetyl Cysteine and Metformin in Polycystic Ovary Syndrome Patients N-acetyl cysteine, Metfomin - Polycystic Ovary Syndrome | Phase 3 | Completed | Cairo University | 102 | 2025-03-01 | 2026-10-21 |
| Reducing Respiratory Symptoms of Pulmonary Irradiation in Interstitial Lung Disease N-Acetyl cysteine, Dexamethasone Oral, N-Acetyl cysteine Placebo - Lung Cancer, Interstitial Lung Disease | Phase 2 | Recruiting | David Palma | 98 | 2025-01-07 | 2026-08-26 |
| Safety and Efficacy of N-Acetylcysteine Mouthwash in Prevention of Mucositis in HSCT Patients N-Acetylcysteine 600mg/tab, Placebo - Oral Mucositis, Hematopoietic Stem Cell Transplantation (HSCT) | Phase 3 | Active not recruiting | Tehran University of Medical Sciences | 106 | 2024-08-18 | 2026-01-08 |
| N-Acetyl Cysteine Effect on Liver Function After Mitral Valve Replacement N acetyl cysteine, normal saline - Oxidative Stress, Liver Dysfunction | Phase 4 | Completed | Kasr El Aini Hospital | 54 | 2024-06-30 | 2025-08-29 |
| A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers NAC, Placebo - Huntington Disease | Phase 2 | Recruiting | Western Sydney Local Health District | 160 | 2024-06-01 | 2025-02-28 |
| A Comparative Study of Neoadjuvant Chemotherapy Versus Upfront Radical Surgery for Upper Tract Urothelial Carcinoma NAC - UTUC, UC (Urothelial Cancer) | Active not recruiting | Changhai Hospital | 120 | 2024-05-15 | 2025-09-04 | |
| Combination of Vitamin C and N-Acetylcysteine to Improve Functional Outcome After Rotator Cuff Repair Ascorbic acid, N-acetyl cysteine, placebo - Rotator Cuff Tears | Phase 4 | Unknown | Mahidol University | 110 | 2024-05-01 | 2024-04-25 |
| The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC (TEAM) n-acetylcystine (NAC)+ albuterol, AeroEclipse-VersaPAP System - Asthma, COPD | Phase 4 | Active not recruiting | University of California, San Francisco | 40 | 2024-04-09 | 2026-08-13 |
| Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery Placebo, NAC, NAC + Whey Protein - Aseptic Muscle Injury | Not applicable | Recruiting | University of Thessaly | 30 | 2024-04-08 | 2025-06-04 |
| NAC for Attenuation of COVID-19 Symptomatology N-acetylcysteine, Placebo - Covid19, COVID-19 Pneumonia | Phase 2 | Unknown | Cambridge Health Alliance | 200 | 2024-03-31 | 2023-08-07 |
| NAC vs Placebo on Opioid Use for Hysterectomy IV N-acetylcysteine, IV Placebo - Hysterectomy | Phase 3 | Completed | Medical University of South Carolina | 240 | 2023-11-30 | 2026-10-09 |
| GWICTIC: NAC Mechanistic Study in Gulf War Veterans N-Acetyl Cysteine, Placebo - Gulf War Syndrome | Early Phase 1 | Recruiting | Nova Southeastern University | 170 | 2023-11-30 | 2025-07-08 |
| Pharmacokinetic Profile of N-Acetyl Cysteine NAC, Neuro-NAC, Neuro-NAC XS - Pharmacokinetics | Not applicable | Completed | University of Memphis | 8 | 2023-09-18 | 2024-12-16 |
Showing 20 of 122. Sign in to see all of them.
Parkinson Disease (4) · Substance-Related Disorders (4) · Acute Kidney Injury (3) · Alcoholism (3) · Asthma (3) · Autistic Disorder (3) · COVID-19 (3) · Cocaine-Related Disorders (3) · Deafness (3) · Marijuana Abuse (3) · Schizophrenia (3) · Behavior, Addictive (2) · Bipolar Disorder (2) · Cognitive Dysfunction (2) · Depression (2)
Medical University of South Carolina (7) · University of California, San Francisco (5) · Yale University (4) · Assiut University (3) · Stanford University (3) · The First Affiliated Hospital of Soochow University (3) · University of Minnesota (3) · Ain Shams University (2) · Hospital de Clinicas de Porto Alegre (2) · Peking University People's Hospital (2) · Sunnybrook Health Sciences Centre (2) · Tanta University (2) · The Aurum Institute NPC (2) · The University of Texas Health Science Center, Houston (2) · University of Chicago (2)
United States (60) · Egypt (8) · Canada (7) · China (5) · Brazil (4) · Turkey (Türkiye) (4) · Australia (3) · Greece (3) · Iran (2) · Slovenia (2) · Tanzania (2) · Denmark (1) · France (1) · Germany (1) · India (1)
Kevin M Gray, MD (3) · Antonio Hardan, MD (2) · Paul Tuite, MD (2) · Xiao-Jun Huang, MD (2) · Alaa M Ismail, M D (1) · Ali J. Marian, MD (1) · All Validations Passed Badran, PhD (1) · Amr Darwish, Lecturer (1) · Amr Z Abdelhamid, PhD (1) · Ashraf Moini, MD (1) · Asimina Mitrakou, Associate Prof. (1) · Astrid M Horstman, PhD (1)
PMID 10836917, PMID 14506405, PMID 15706734, PMID 16363316, PMID 16373736, PMID 19581567, PMID 22342106, PMID 23251869, PMID 23860343, PMID 25073872, PMID 25148231, PMID 26860769, PMID 26922582, PMID 27007062, PMID 27309537, PMID 27411777, PMID 27736051, PMID 28623823, PMID 28847455, PMID 28911971, PMID 29130810, PMID 29513609, PMID 29540445, PMID 29619634, PMID 30549489, PMID 31015207, PMID 31405750, PMID 31712969, PMID 33675156, PMID 33725178, PMID 34197135, PMID 34446544, PMID 34582562, PMID 34623633, PMID 35084903, PMID 35288511, PMID 35473809, PMID 36114762, PMID 36182028, PMID 36514019, PMID 36856701, PMID 37271412, PMID 37848768, PMID 37916745, PMID 39189858, PMID 40921646, PMID 41577060, PMID 41749341, PMID 42108273, PMID 42829889
I01CX000264 (1), K01DA039299 (1), P30CA015083 (1), P50DA046373 (1), R01DA026777 (1), R01HL080414 (1), R21AG041509 (1), R21AT004490 (1), R21DA024756 (1), R34DA042228 (1), U10DA013045 (1), U10DA013727 (1), U10DA013732 (1), U10DA015815 (1), U10DA015831 (1)