19 completed, 5 recruiting, 4 unknown, 2 terminated. 33 Phase 2, 5 Phase 1, 3 Phase 3.
Follow Hydromorphone: new trials by email Literature Review of Hydromorphone trials Research Report on Hydromorphone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Evaluation of Polypharmacy Effects for Pain Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin) - Chronic Lower Back Pain (CLBP) | Phase 1 / Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 110 | 2027-01-15 | 2026-09-29 |
| Buprenorphine for Analgesia in Older Adults With Acute Fractures in the Emergency Department Buprenorphine 0.15 MG, Hydromorphone 0.25 mg IV - Fracture | Phase 1 / Phase 2 | Recruiting | The Cooper Health System | 48 | 2026-05-07 | 2026-06-29 |
| Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation fentanyl, Hydromorphone - Mechanical Ventilation, Sedation and Analgesia | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 319 | 2025-11-03 | 2026-07-14 |
| Intravenous Hydromorphone for the Treatment of Acute Pain Hydromorphone - Acute Chest Pain | Phase 1 / Phase 2 | Recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 30 | 2025-01-01 | 2025-11-17 |
| Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy Bupivacaine, Hydromorphone, Iopamidol - Duodenal Neoplasm, Pancreatic Neoplasm | Phase 2 | Recruiting | Masonic Cancer Center, University of Minnesota | 78 | 2023-11-10 | 2026-02-03 |
| Efficacy and Safety of Hydromorphone-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia Hydromorphone, Sufentanil, Ropivacaine - Analgesia, Labor Pain | Phase 2 | Unknown | Maternal and Child Health Hospital of Hubei Province | 240 | 2023-09-17 | 2023-10-26 |
| NSAID Use After Robotic Partial Nephrectomy Ketorolac, Acetaminophen, Oxycodone - Kidney Cancer, Renal Cancer | Phase 2 | Active not recruiting | University of Miami | 137 | 2023-09-15 | 2026-10-23 |
| The Evaluation of the Effectiveness and Safety of Nalbuphine Hydrochloride Injection for Analgesia in ICU Patients: A Multicenter, Randomized, Single-blinded, Parallel, Two-step Trial Nalbuphine hydrochloride injection, Hydromorphone hydrochloride injection - Respiratory Insufficiency | Phase 2 / Phase 3 | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 204 | 2023-08-30 | 2025-01-21 |
| Effect of Epidural Hydromorphone Combined With Ropivacaine in Labor Analgesia Hydromorphone, Sufentanil, Ropivacaine - Analgesia, Labor Pain | Phase 2 | Completed | Maternal and Child Health Hospital of Hubei Province | 240 | 2022-06-01 | 2023-06-13 |
| Pediatric Pain Optimization After Tonsillectomy Fentanyl/Hydromorphone, Methadone - Obstructive Sleep Apnea, Tonsillitis | Phase 2 | Completed | Duke University | 66 | 2022-04-08 | 2024-10-17 |
| Initial Pain Management in Pediatric Pancreatitis: Opioid vs. Non-Opioid Ketorolac, Opioid - Acute Pancreatitis | Phase 2 | Terminated | Boston Children's Hospital | 23 | 2022-03-15 | 2026-01-08 |
| The Effects of ECMO on the Pharmacokinetics of Hydromorphone Hydromorphone - Extracorporeal Membrane Oxygenation | Phase 2 | Unknown | Xiaobo Yang, MD | 26 | 2022-01-01 | 2024-08-06 |
| Assessing a Clinically-meaningful Opioid Withdrawal Phenotype Hydromorphone, Naloxone + lofexidine pretreatment, Naloxone + placebo pretreatment - Opioid Withdrawal, Opioid Use Disorder | Phase 2 | Recruiting | University of Maryland, Baltimore | 60 | 2021-12-01 | 2025-09-12 |
| Comparing Rapid Micro-Induction and Standard Induction of Buprenorphine/Naloxone for Treatment of Opioid Use Disorder Buprenorphine/naloxone, Hydromorphone - Opioid Use Disorder | Phase 2 | Unknown | University of British Columbia | 50 | 2021-08-18 | 2024-06-11 |
| Inhaled Cannabinoids Versus Immediate-release Oral Opioids for the Management of Breakthrough Cancer Pain PPP001, Morphine sulfate or Hydromorphone or Oxycodone - Cancer, Breakthrough Cancer Pain | Phase 2 | Unknown | Tetra Bio-Pharma | 20 | 2021-05-26 | 2021-07-28 |
| Non-Steroidal or Opioid Analgesia Use for Children With Musculoskeletal Injuries Ibuprofen, Acetaminophen, Hydromorphone - Musculoskeletal Injury | Phase 2 | Completed | University of Alberta | 710 | 2019-04-20 | 2024-09-19 |
| Study in Subjects Undergoing Complete Abdominoplasty CA-008 5 mg, Placebo, Bupivacaine Hydrochloride - Postsurgical Pain | Phase 2 | Completed | Concentric Analgesics | 54 | 2018-12-03 | 2024-03-19 |
| Acetaminophen Versus IV Hydromorphone for Pain in the Elderly in the ED Acetaminophen 1000mg IV, Hydromorphone 0.5 mg IV - Acute Pain | Phase 2 | Completed | Montefiore Medical Center | 162 | 2018-08-20 | 2023-03-02 |
| A Study to Evaluate the Abuse Potential of Oxymorphone Compared to Other Mu Opioid Agonists. Intravenous Challenge Drug - Opioid Use Disorder | Phase 2 | Completed | New York State Psychiatric Institute | 16 | 2018-03-15 | 2023-09-07 |
| Intranasal Hydromorphone for the Treatment of Acute Pain in Children: A Pilot Study. Hydromorphone - Pain | Phase 2 | Completed | Columbia University | 35 | 2015-05-01 | 2019-05-28 |
Showing 20 of 33. Sign in to see all of them.
Agnosia (6) · Emergencies (6) · Opioid-Related Disorders (6) · Pain (6) · Acute Pain (4) · Labor Pain (3) · Pain, Postoperative (2) · Anemia, Sickle Cell (1) · Duodenal Neoplasms (1) · Fractures, Bone (1) · Kidney Neoplasms (1) · Lymphoma, Follicular (1) · Neoplasms (1) · Pain, Procedural (1) · Pancreatic Neoplasms (1)
Montefiore Medical Center (4) · Emory University (2) · Maternal and Child Health Hospital of Hubei Province (2) · University of Maryland, Baltimore (2) · Albert Einstein College of Medicine (1) · Alkermes, Inc. (1) · Beth Israel Deaconess Medical Center (1) · Boston Children's Hospital (1) · Columbia University (1) · Concentric Analgesics (1) · Duke University (1) · Hordinsky, Maria K., MD (1) · Icahn School of Medicine at Mount Sinai (1) · Indivior Inc. (1) · Masonic Cancer Center, University of Minnesota (1)
United States (24) · China (5) · Canada (3)
Andrew K Chang, MD (3) · Grant C Lynde, MD (2) · Na Li, MD (2) · Adrienne Birnbaum, MD (1) · Alina Beaton, MD (1) · Amit Grover, MB BCh BAO (1) · Benjamin Friedman, MD (1) · Bernard L. Silverman, MD (1) · Daniel Tsze, MD, MPH (1) · Elias N Baedorf-Kassis, MD (1) · Eric C Strain, M.D. (1) · Graeme M Rocker, DM MHSc (1) · James Flaherty (1) · Kelly E Dunn, Ph.D, M.B.A. (1)
PMID 21467190, PMID 22079773, PMID 25077099, PMID 26286816, PMID 26650971, PMID 30290794, PMID 30902361, PMID 32565458, PMID 32883371, PMID 33579359, PMID 35965162, PMID 36467036, PMID 37023945, PMID 38669011, PMID 41505155, PMID 42131816, PMID 42438343
P30CA077598 (1), R01DA018125 (1), R01DA052937 (1), R01DA061796 (1)