40 completed, 10 terminated, 6 recruiting, 4 unknown. 65 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 65 | Completed 40, Terminated 10, Recruiting 6, Unknown 4, Active not recruiting 2, Withdrawn 2, Suspended 1 |
Follow Hydromorphone: new trials by email Literature Review of Hydromorphone trials Research Report on Hydromorphone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Intrathecal Hydromorphone vs Intrathecal Morphine to Treat Post Cesarean Pain in Patients With Opioid Use Disorder Taking Buprenorphine Morphine, Bupivacaine, Fentanyl - Opioid Use Disorder | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2026-02-01 | 2026-03-09 | |
| Reducing Pain With Methadone and Ketamine in Liver Transplant Methadone, ketamine, Hydromorphone - Liver Transplantation | Phase 4 | Completed | Lahey Clinic | 50 | 2025-06-30 | 2026-08-11 |
| Optimizing Perioperative Analgesia to Lower Pain Following Cleft Palate Surgery Methadone hydrochloride, Fentanyl/Hydromorphone - Cleft Palate, Pain | Phase 4 | Recruiting | Duke University | 60 | 2025-06-04 | 2026-04-14 |
| Hydromorphone Hydrochloride Epidural Preemptive Analgesia for Postoperative Pain After Cesarean Section Hydromorphone hydrochloride low dose, Hydromorphone hydrochloride high dose, 0.9% sodium chloride - Post-surgical Pain | Phase 4 | Completed | Liquan Liang | 105 | 2025-03-03 | 2025-09-05 |
| Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial NSAID, Opioid, Acetaminophen - Surgery, Pain, Post Operative | Phase 4 | Recruiting | University of Michigan | 900 | 2025-01-10 | 2026-10-20 |
| Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia Methadone, Fentanyl/Hydromorphone - Pain, Postoperative, Tonsillar Hypertrophy | Phase 4 | Recruiting | Duke University | 440 | 2024-11-21 | 2025-12-05 |
| Personalized Post-Operative Pain Management PGx guided personalized post-operative pain management, Oxycodone, Hydromorphone - Persistent Post Operative Opioid Use, Post-surgical Pain | Phase 4 | Active not recruiting | University of Tennessee Graduate School of Medicine | 208 | 2024-09-25 | 2024-11-01 |
| Ketamine for Sedation in Severe Traumatic Brain Injury Ketamine with propofol, Standard of Care propofol, fentanyl, dexmedetomidine, morphine, hydromorphone, midazolam, or lorazepam - Severe Traumatic Brain Injury, Intracranial Hypertension | Phase 4 | Suspended | Henry M. Jackson Foundation for the Advancement of Military Medicine | 50 | 2024-09-23 | 2025-07-14 |
| Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery Hydromorphone, Methadone, Questionnaire Administration - Malignant Female Reproductive System Neoplasm | Phase 4 | Recruiting | Mayo Clinic | 140 | 2024-09-03 | 2026-03-04 |
| Enhanced Recovery After Surgery-Based Multimodal Preemptive Analgesia for Perioperative Management in Transarterial Chemoembolization of Intermediate-to-Advanced Hepatocellular Carcinoma hydrochloride hydromorphone + flurbiprofen axetil, conventional analgesia - Enhanced Recovery After Surgery, Multimodal Analgesia | Phase 4 | Completed | First Affiliated Hospital, Sun Yat-Sen University | 129 | 2024-08-01 | 2026-01-02 |
| Hydromorphone for Perioperative Analgesia in Lung Tumor Ablation Parallel Controlled Hydromorphone Hydrochloride, Morphine hydrochloride - Pulmonary Nodule, Ablation | Phase 4 | Unknown | Qianfoshan Hospital | 88 | 2023-05-01 | 2023-05-08 |
| A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair Hydromorphone 2.5 mcg/kg, Hydromorphone 2.75 mcg/kg, Hydromorphone 3 mcg/kg - Pain Control | Phase 4 | Terminated | Mayo Clinic | 31 | 2023-03-23 | 2026-05-14 |
| Intrathecal Opioids for Colorectal Resection Morphine, Hydromorphone - Colorectal Surgery, Pain, Postoperative | Phase 4 | Completed | Mayo Clinic | 80 | 2021-03-10 | 2024-03-26 |
| High Dose IV Lidocaine vs Hydromorphone for Abdominal Pain in the Emergency Department Lidocaine Iv, HYDROmorphone Injection - Abdominal Pain, Renal Colic | Phase 4 | Terminated | Hennepin Healthcare Research Institute | 4 | 2021-02-18 | 2024-01-17 |
| Multimodal Analgesia Effect on Post Surgical Patient Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product - Obesity, Morbid, Surgery | Phase 4 | Completed | University of California, Davis | 60 | 2021-01-20 | 2026-09-14 |
| Effect of Opioid Infusion Rate on Abuse Liability Potential of Intravenous Hydromorphone for Cancer Pain Hydromorphone, Placebo Administration, Questionnaire Administration - Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm | Phase 4 | Active not recruiting | M.D. Anderson Cancer Center | 84 | 2020-09-10 | 2026-06-16 |
| Hydromorphone for ICU-analgesia in Patients With Non-mechanical Ventilation Hydromorphone, Fentanyl, Butorphanol - Hydromorphone, Analgesia | Phase 4 | Completed | Nanfang Hospital, Southern Medical University | 530 | 2020-09-04 | 2026-09-02 |
| Liposomal Bupivacaine With or Without Hydromorphone for the Improvement of Pain Control After Laparotomy in Patients With Gynecological Malignancies Hydromorphone, Laparotomy, Liposomal Bupivacaine - Malignant Female Reproductive System Neoplasm | Phase 4 | Completed | Mayo Clinic | 105 | 2020-07-09 | 2024-10-16 |
| Non-analgesic Effects Produced by Equipotent Analgesic Doses of Sufentanil, Hydromorphone, and Oxycodone Sufentanil, Hydromorphone, Oxycodone - Opioid Use | Phase 4 | Completed | Peking University People's Hospital | 80 | 2020-05-20 | 2024-05-30 |
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Pain, Postoperative (20) · Pain (17) · Agnosia (9) · Emergencies (7) · Acute Pain (4) · Nausea (3) · Abdominal Pain (2) · Constipation (2) · Anemia, Sickle Cell (1) · Body Weight Changes (1) · Brain Injuries, Traumatic (1) · Breakthrough Pain (1) · Cancer Pain (1) · Carcinoma, Hepatocellular (1) · Chronic Pain (1)
Montefiore Medical Center (8) · Mayo Clinic (5) · Duke University (4) · Endeavor Health (3) · M.D. Anderson Cancer Center (3) · University of Erlangen-Nürnberg Medical School (3) · University of Southern California (2) · AUVA Traumazentrum Vienna Site UKH Meidling (1) · AdventHealth (1) · Andrew A Herring (1) · Baylor College of Medicine (1) · Brigham and Women's Hospital (1) · Columbia University (1) · Dr. Anthony Ho (1) · Endo USA Inc., a Keenova Therapeutics Company (1)
United States (46) · China (7) · Canada (4) · Germany (3) · Austria (1)
Glenn S Murphy, MD (3) · Adam W Amundson, MD (1) · Amy Penwarden, MD (1) · Andrew Chang, M.D. (1) · Andrew Chang, MD, MS (1) · Andrew Herring, MD (1) · Andrew K Chang, MD, MS (1) · Anthony MH Ho, MD,FRCPC (1) · Arun Nagdev, MD (1) · Barbara Jachniewicz, MSN, CRNFA, (1) · Benjamin W Friedman, MD, MS (1) · Bradley Dengler, MD (1) · Carrie Y Peterson, MD (1) · Chris Glover, MD (1) · Christian Jeleazcov, MD (1)
PMID 15151094, PMID 15791113, PMID 18806056, PMID 19135997, PMID 19209273, PMID 19331993, PMID 19338859, PMID 19535182, PMID 20173643, PMID 20890791, PMID 21102969, PMID 22008309, PMID 22357901, PMID 22524979, PMID 23221859, PMID 23379573, PMID 23406078, PMID 23846749, PMID 24937669, PMID 26797808, PMID 26827847, PMID 27529160, PMID 28648803, PMID 29046364, PMID 30119941, PMID 30344172, PMID 30819520, PMID 31938928, PMID 32649717, PMID 32884990, PMID 33009192, PMID 33547559, PMID 34124111, PMID 34363617, PMID 34405295, PMID 37833472, PMID 38447097, PMID 38669783, PMID 38876786, PMID 40114986, PMID 41063733, PMID 42208996, PMID 9204163
K23AG033100 (1), R01DA042985 (1), R01HD114678 (1)