69 completed, 15 unknown, 6 withdrawn, 5 terminated. 98 Phase 2, 25 Phase 3, 16 Phase 1.
Follow Fentanyl: new trials by email Literature Review of Fentanyl trials Research Report on Fentanyl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade Naloxone Hydrochloride, Fentanyl, Sterile Saline - Fentanyl Overdose, Fentanyl Poisoning | Phase 2 | Completed | Clear Scientific, Inc. | 16 | 2026-05-28 | 2026-11-10 |
| Prospective IR-led Sedation Feasibility ketamine, Fentanyl (IV), Midazolam - Anesthesia, Sedation and Analgesia | Phase 1 / Phase 2 | Recruiting | CAMC Health System | 40 | 2026-03-02 | 2026-03-09 |
| Effect of Dexmedetomidine Dosage on Postoperative Delirium in Geriatric Orthopedic Surgery Dexmedetomidine (Low dose), Dexmedetomidine (High dose), Fentanyl - Delirium - Postoperative | Phase 2 | Completed | Benha University | 75 | 2026-02-26 | 2026-08-25 |
| Fentanyl Versus Hydromorphone in Patients on Mechanical Ventilation fentanyl, Hydromorphone - Mechanical Ventilation, Sedation and Analgesia | Phase 2 | Completed | Beth Israel Deaconess Medical Center | 319 | 2025-11-03 | 2026-07-14 |
| Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg) - Acute Stress Disorder, Anxiety | Phase 2 | Withdrawn | Nationwide Children's Hospital | 2025-09-01 | 2025-09-10 | |
| Opiranserin Injections PCA Regimens for Postoperative Pain VVZ-149 Injections, Fentanyl - Pain, Postoperative / Acute Pain | Phase 2 | Completed | Samsung Medical Center | 66 | 2025-07-22 | 2026-09-15 |
| Dexmedetomidine Versus Fentanyl as Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: A Randomized Clinical Trial Erector Spinae Plane Block, Dexmedetomidine, fentanyl - Nephrectomy | Phase 2 / Phase 3 | Unknown | Assiut University | 46 | 2025-03-01 | 2025-01-29 |
| Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries. Fentanyl - Postoperative Pain | Phase 2 | Unknown | Assiut University | 100 | 2024-09-01 | 2024-08-01 |
| Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery Dexmedetomidine, Fentanyl - Anesthesia and Analgesia, Anesthesia, Endotracheal | Phase 2 / Phase 3 | Unknown | Universitas Indonesia | 104 | 2024-06-01 | 2024-04-30 |
| Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery Ultrasound- guided Fascia Transversalis plane block, Ultrasound-guided Transversus abdominus plane block, Fentanyl - Fascia Transversalis Plane Block | Phase 2 | Completed | Kasr El Aini Hospital | 50 | 2024-04-01 | 2026-06-16 |
| Dexmedetomidine as an Adjunct to Fentanyl for Term Neonates on Mechanical Ventilation Dexmedetomidine, fentanyl 1mcg/kg/hr, fentanyl 0.5 mcg/kg/hr - Analgesia, Sedation and Analgesia | Phase 2 / Phase 3 | Completed | Ain Shams University | 40 | 2024-03-01 | 2025-12-02 |
| Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries Caudal epidural analgesia, Ultrasound-guided Combined Pericapsular Nerve Group Block, Ultrasound-guided Lateral Femoral Cutaneous Nerve Block - Pericapsular Nerve Group Block | Phase 2 | Completed | Kasr El Aini Hospital | 68 | 2024-03-01 | 2026-06-16 |
| Pain Managment in Preterm Neonates fentanyl - Preterm Neonates Pain Managment, PreTerm Neonate | Phase 2 / Phase 3 | Completed | Ain Shams University | 52 | 2024-02-01 | 2025-08-29 |
| Organ Protective Effect of Cetirizine In Patients With Severe Burns Cetirizine, Midazolam and Fentanyl - Burns | Phase 1 / Phase 2 | Unknown | Ruijin Hospital | 32 | 2024-01-23 | 2024-02-01 |
| Ultrasound Guided Pericapsular Nerve Block Versus iv Sedation Analgesia in Reduction of Shoulder Dislocation Propofol injection and fentanyl, Bupivacain - Perioperative Pain | Phase 2 | Completed | Benha University | 42 | 2023-11-15 | 2026-02-06 |
| Opioid Free Anesthesia in Abdominal Laparoscopic Surgery Dexmedetomidine, Fentanyl - Laparoscopic Surgery, Abdominal Surgery | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 74 | 2023-07-01 | 2024-05-03 |
| Inhalational or Intravenous Anesthesia During Surgery for Patients With Colon Cancer, VIVA Study Biospecimen Collection, Electronic Health Record Review, Fentanyl Citrate - Colon Adenocarcinoma | Phase 2 | Unknown | University of Kansas Medical Center | 80 | 2023-05-22 | 2023-08-30 |
| Efficacy of Adding Low Dose Ketamine or Fentanyl to Propofol-dexmedetomidine as Total Intravenous Anesthesia Ketamine - Patients Undergoing Elective Craniotomy | Phase 1 / Phase 2 | Completed | Minia University | 40 | 2023-02-01 | 2025-07-30 |
| Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia Clonidine, Dexmedetomidine, Fentanyl - Pregnancy Related | Phase 2 | Completed | Grace Lim, MD, MS | 88 | 2022-09-28 | 2025-04-27 |
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Pain (14) · Agnosia (11) · Neoplasms (8) · Pain, Postoperative (8) · Anemia, Sickle Cell (3) · Breakthrough Pain (3) · Burns (3) · Acute Pain (2) · Anxiety Disorders (2) · Chronic Pain (2) · Dyspnea (2) · Fractures, Bone (2) · Hematoma, Subdural, Chronic (2) · Pain, Procedural (2) · Asthma (1)
Assiut University (8) · Kasr El Aini Hospital (6) · Hospira, now a wholly owned subsidiary of Pfizer (3) · Nationwide Children's Hospital (3) · Ain Shams University (2) · Benha University (2) · Cephalon (2) · Concentric Analgesics (2) · Duke University (2) · INSYS Therapeutics Inc (2) · Janssen Pharmaceutical K.K. (2) · Johns Hopkins University (2) · Qazvin University Of Medical Sciences (2) · Universitas Indonesia (2) · University of Patras (2)
United States (38) · Egypt (21) · Canada (4) · Greece (4) · Iran (3) · South Korea (3) · Germany (2) · Guatemala (2) · Japan (2) · Puerto Rico (2) · Thailand (2) · Brazil (1) · China (1) · Denmark (1) · France (1)
Giovanni DeCastro (2) · Alina Beaton, MD (1) · Amy R Deipolyi, M.D., Ph.D. (1) · Aymen N Naguib, MD (1) · Ban Leong Sng, FANZCA (1) · Benno von Bormann, MD (1) · Bradford Winters, MD (1) · Christina G Sklavou, MD (1) · Craig G Crandall, PhD (1) · Cyrus V Edelson, MD (1) · David Hui, MD (1) · Deborah Stein, MD (1) · Dudley Hammon (1) · Elias N Baedorf-Kassis, MD (1)
PMID 24238862, PMID 10353500, PMID 17581533, PMID 18258412, PMID 19249923, PMID 19508134, PMID 20456062, PMID 21215653, PMID 21926576, PMID 22156333, PMID 22211775, PMID 23160979, PMID 23233109, PMID 23355160, PMID 23380337, PMID 23389068, PMID 23762043, PMID 23830530, PMID 24385406, PMID 24604566, PMID 24649361, PMID 25293474, PMID 26056838, PMID 27501016, PMID 27609854, PMID 27847698, PMID 27918333, PMID 28272292, PMID 28492298, PMID 28781453, PMID 29226529, PMID 29261601, PMID 29746445, PMID 29794943, PMID 30662387, PMID 33849367, PMID 35301896, PMID 35306524, PMID 35796486, PMID 35953455, PMID 36843581, PMID 37170709, PMID 37491196, PMID 37811840, PMID 37990597, PMID 38669011, PMID 38892876, PMID 39732915, PMID 40113655, PMID 42049811
2005 (1), P30CA168524 (1), P50DA009236 (1), UG3DA059286 (1)