74 completed, 15 unknown, 6 active not recruiting, 6 terminated. 108 Phase 3, 25 Phase 2.
Follow Fentanyl: new trials by email Literature Review of Fentanyl trials Research Report on Fentanyl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ropivacaine and Fentanyl for Labor Epidural Initiation Ropivacaine + Fentanyl - Pregnancy, Labor and Delivery | Phase 3 | Recruiting | University of California, San Francisco | 50 | 2025-10-24 | 2026-01-27 |
| Pain Control Alternatives in Pediatric Patients With Distal Radius Fractures Ketamine + Lidocaine, Ketamine group, Fentanyl (Nasalfent, Fentanyl Citrate Nasal Spray) - Distal Radius Fracture Reduction, Pain Control | Phase 3 | Recruiting | State University of New York at Buffalo | 50 | 2025-08-22 | 2025-10-10 |
| Effect of Different Anesthetic Drugs on Electrocorticography (ECOG). Fentanyl (IV), Ketamine (0.5 mg/kg) - Epilepsy, Brain Tumor | Phase 3 | Active not recruiting | Children's Cancer Hospital Egypt 57357 | 88 | 2025-08-18 | 2025-09-10 |
| Dexmedetomidine Versus Fentanyl as Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: A Randomized Clinical Trial Erector Spinae Plane Block, Dexmedetomidine, fentanyl - Nephrectomy | Phase 2 / Phase 3 | Unknown | Assiut University | 46 | 2025-03-01 | 2025-01-29 |
| Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine Morphine, IN fentanyl, IN ketamine - Limb Injury | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2025-02-26 | 2026-03-27 |
| What Causes Low Blood Pressure After Anesthesia in Older Adults Having Non-Heart Surgery ? Standard General Anesthesia Induction Using Propofol, Fentanyl and Midazolam, Blood Pressure Continous Monitoring, syrnge pump for the anesthesia agent, and vasoconstrictor drug - Geriatric, General Anesthesia Induced Hypotension | Phase 3 | Completed | Universitas Indonesia | 220 | 2024-09-01 | 2025-06-13 |
| Intranasal Fentanyl in Preterm Infants Undergoing Peripherally Inserted Central Catheter Placement Fentanyl, Normal saline - Procedural Pain | Phase 3 | Completed | Mount Sinai Hospital, Canada | 8 | 2024-08-09 | 2025-02-20 |
| Opioid Free Versus Opioid Balanced Anesthesia in Ophthalmic Surgery Dexmedetomidine, Fentanyl - Anesthesia and Analgesia, Anesthesia, Endotracheal | Phase 2 / Phase 3 | Unknown | Universitas Indonesia | 104 | 2024-06-01 | 2024-04-30 |
| Dexmedetomidine as an Adjunct to Fentanyl for Term Neonates on Mechanical Ventilation Dexmedetomidine, fentanyl 1mcg/kg/hr, fentanyl 0.5 mcg/kg/hr - Analgesia, Sedation and Analgesia | Phase 2 / Phase 3 | Completed | Ain Shams University | 40 | 2024-03-01 | 2025-12-02 |
| Pain Managment in Preterm Neonates fentanyl - Preterm Neonates Pain Managment, PreTerm Neonate | Phase 2 / Phase 3 | Completed | Ain Shams University | 52 | 2024-02-01 | 2025-08-29 |
| Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial Fentanyl Citrate, Esketamine - Acute Pain Due to Trauma, Analgesia | Phase 3 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 235 | 2024-01-11 | 2026-09-15 |
| Prehospital Analgesia INtervention Trial (PAIN) Ketamine Hydrochloride, Fentanyl Citrate - Traumatic Injury | Phase 3 | Recruiting | Jason Sperry | 994 | 2023-11-27 | 2026-03-09 |
| Opioid Free Anesthesia in Abdominal Laparoscopic Surgery Dexmedetomidine, Fentanyl - Laparoscopic Surgery, Abdominal Surgery | Phase 2 / Phase 3 | Completed | Universitas Indonesia | 74 | 2023-07-01 | 2024-05-03 |
| Comparison Between Bupivacaine With and Without Fentanyl in Reducing Pain During Cesarean Delivery Under Spinal Anaesthesia 0.5% bupivacaine heavy, 0.5% bupivacaine heavy with fentanyl - Visceral Pain | Phase 3 | Completed | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 72 | 2022-09-20 | 2023-04-25 |
| Effect of Topically Administered Levobupivacaine- Fentanyl Versus Levobupivacaine- Dexamethasone Combination in the Control of Pain After Endoscopic Sinus Surgery Saline 0.9%, Levobupivacaine Hydrochloride, Fentanyl - Endoscopic Sinus Surgery, Fentanyl | Phase 2 / Phase 3 | Unknown | Assiut University | 80 | 2021-12-01 | 2021-12-06 |
| A Comparison of Three Regimens of Acute Pain Management: Methoxyflurane; Intranasal Fentanyl; Intravenous Morphine Methoxyflurane, Fentanyl, Morphine hydrochloride - Acute Pain, Ambulances | Phase 3 | Completed | Oslo University Hospital | 338 | 2021-11-12 | 2023-11-14 |
| Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in Intensive Care Unit Remifentanil, Fentanyl - Analgesia | Phase 3 | Unknown | Southeast University, China | 138 | 2021-08-01 | 2022-12-08 |
| Efficacy and Safety of Remifentanil for Mechanically Ventilated Patients in ICU Remifentanil, Fentanyl - Analgesia | Phase 3 | Unknown | Southeast University, China | 138 | 2021-06-10 | 2022-08-11 |
| Methadone Anesthesia For Kidney Transplant Receptors Methadone, Fentanyl - Renal Failure Chronic, Surgery | Phase 3 | Unknown | University of Sao Paulo General Hospital | 32 | 2021-05-17 | 2021-06-01 |
| Postoperative Consequences of Intraoperative NOL Titration Routine opioid management, PMD-200 Nol-guided opioid administration - Anesthesia; Adverse Effect | Phase 3 | Completed | The Cleveland Clinic | 72 | 2020-12-30 | 2024-06-21 |
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Janssen Pharmaceutical K.K. (6) · Assiut University (5) · Archimedes Development Ltd (3) · Hospira, now a wholly owned subsidiary of Pfizer (3) · KK Women's and Children's Hospital (3) · Kyowa Kirin Co., Ltd. (3) · M.D. Anderson Cancer Center (3) · Universitas Indonesia (3) · University of Patras (3) · University of Sao Paulo General Hospital (3) · Ain Shams University (2) · BioDelivery Sciences International (2) · Cairo University (2) · Cephalon (2) · INSYS Therapeutics Inc (2)
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PMID 24238862, PMID 26359327, PMID 11591092, PMID 14693585, PMID 14693611, PMID 15180019, PMID 16284992, PMID 16803911, PMID 18946302, PMID 19249923, PMID 19348675, PMID 20456062, PMID 20822038, PMID 21208151, PMID 21471025, PMID 21957829, PMID 22156333, PMID 22211775, PMID 22456770, PMID 22480131, PMID 23160979, PMID 23233109, PMID 23355160, PMID 23389068, PMID 23582138, PMID 23762043, PMID 24465046, PMID 24900938, PMID 25293474, PMID 25378647, PMID 27020837, PMID 27387971, PMID 27501016, PMID 27847698, PMID 27918333, PMID 28272292, PMID 28492298, PMID 28781453, PMID 2900154, PMID 29226529, PMID 29261601, PMID 29746445, PMID 29794943, PMID 30202425, PMID 30592476, PMID 33849367, PMID 35301896, PMID 36727855, PMID 37491196, PMID 37811840
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