103 completed. 103 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 103 | Completed 103 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000 - Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block | Phase 4 | Completed | Rehman Medical Institute - RMI | 50 | 2026-03-03 | 2026-10-09 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Lidocaine Versus Bupivacaine in Orthognathic Surgery 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine - Pain, Postoperative, Numbness | Phase 4 | Completed | Boston Children's Hospital | 64 | 2024-10-01 | 2026-08-04 |
| Intrathecal Dexmedetomidine vs Epinephrine Dexmedetomidine, Epinephrine, Standardized Spinal Mixture - Cesarean Section, Anesthesia, Spinal | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 90 | 2024-09-17 | 2026-06-17 |
| Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia 2% Mepivacaine with 1:100,000 epinephrine, 2% Mepivacaine with 1:55,000 Epinephrine Bitartrate - Hemodynamics, Pain | Phase 4 | Completed | King Abdulaziz University | 52 | 2024-02-10 | 2025-06-12 |
| The Use of Lidocaine Gel Versus Subconjunctival Xylocaine Injection in Pterygium Excision OPHTESIC LIDOCAINE HYDROCHLORIDE 20MG/G, Xylocaine with Epinephrine - Pterygium | Phase 4 | Completed | Vrije Universiteit Brussel | 41 | 2023-09-01 | 2026-08-25 |
| Comparison of Two Different Concentrations of Local Anesthetic in Patient Reported Pain in Oculoplastic Surgery Full strength lidocaine with epinephrine, Dilute lidocaine with epinephrine - Dermatochalasis, Dermatochalasis of Eyelid | Phase 4 | Completed | Timothy Ekhlassi | 30 | 2023-08-07 | 2024-09-20 |
| Split Face Study of the Duration of Local Anesthetics lidocaine + epinephrine 1:100,000, Ropivacaine 0.5% Injectable Solution, Bupivacaine 0.5% Injectable Solution - Anesthetics, Local | Phase 4 | Completed | Weill Medical College of Cornell University | 75 | 2023-03-14 | 2024-09-19 |
| Papillary Epinephrine Injection vs Rectal Indomethacin Epinephrine injection, Indomethacin - Post-ERCP Acute Pancreatitis | Phase 4 | Completed | Duzce University | 504 | 2023-01-01 | 2026-07-17 |
| Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions Liposomal bupivacaine, 0.5% bupivacaine with 1:100,000 epinephrine - Post Operative Pain | Phase 4 | Completed | University of Southern California | 85 | 2022-09-01 | 2026-06-04 |
| Subacromial Injection of Epinephrine Improves Visualization in Shoulder Arthroscopy Bupivacaine with Epinephrine, Bupivacaine alone - Shoulder Arthroscopy | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 60 | 2022-03-14 | 2023-11-03 |
| Periarticular Bupivacaine + Meloxicam ER Solution Versus Standard Practice During Total Knee Arthroplasty HTX-011, ropivacaine , epinephrine , ketorolac diluted in sodium chloride - Total Knee Arthroplasty | Phase 4 | Completed | Mayo Clinic | 209 | 2022-03-11 | 2025-04-27 |
| Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis Onset Sodium Bicarbonate Inj., 8.4%, USP Neutralizing Additive Solution, 2% lidocaine with 1:100,000 epinephrine - Symptomatic Irreversible Pulpitis | Phase 4 | Completed | Indiana University | 40 | 2022-02-14 | 2024-05-14 |
| EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES Tranexamic Acid (Topical), Tumescent solution with dilute lidocaine and epinephrine - Liposuction, Bruising | Phase 4 | Completed | Total Definer Research Group | 78 | 2022-01-20 | 2025-04-30 |
| Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery Toradol, Morphine, Orphenadrine - Pain Management, Posterior Spinal Fusion | Phase 4 | Completed | University of Puerto Rico | 100 | 2021-04-05 | 2022-06-10 |
| Adrenaline for the Treatment of No-Reflow in Normotensive Patients Adrenaline, Adenosine - Acute Coronary Syndrome, No-Reflow Phenomenon | Phase 4 | Completed | National Institute of Cardiovascular Diseases, Pakistan | 201 | 2021-01-01 | 2021-05-21 |
| Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery Epinephrine, Tranexamic acid, Epinephrine and Tranexamic Acid - Rotator Cuff Injuries, Rotator Cuff Tears | Phase 4 | Completed | Panam Clinic | 128 | 2020-09-01 | 2024-04-02 |
| Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome 1% Atropine drops, Epinephrine - Intraoperative Floppy Iris Syndrome, Cataract | Phase 4 | Completed | University Hospital Olomouc | 164 | 2020-07-01 | 2024-02-20 |
| Post-cesarean Analgesia With Epidural Morphine Following Epidural 2-chloroprocaine 2% lidocaine with 1:200,000 epinephrine and epidural morphine, 3% 2-chloroprocaine and epidural morphine - Physiological Effect of Drugs, Morphine | Phase 4 | Completed | The University of Texas Health Science Center, Houston | 44 | 2020-05-11 | 2022-05-26 |
| Rib Fracture Analgesia Using Cryoanalgesia Cryoneurolysis with a Painblocker (Epimed International, Farmers Branch, Texas), Intercostal nerve block ropivacaine with epinephrine, Sham cryoneurolysis with a Painblocker - Traumatic Rib Fracture(s) | Phase 4 | Completed | University of California, San Diego | 20 | 2020-04-03 | 2024-10-10 |
Showing 20 of 103. Sign in to see all of them.
Pain, Postoperative (18) · Pain (11) · Agnosia (5) · Osteoarthritis, Knee (3) · Acute Pain (2) · Anaphylaxis (2) · Bronchiolitis (2) · Hip Dislocation (2) · Hypotension (2) · Lacerations (2) · Osteoarthritis (2) · Osteoarthritis, Hip (2) · Acute Coronary Syndrome (1) · Ankle Fractures (1) · Arrhythmias, Cardiac (1)
Mayo Clinic (3) · Netherlands Institute for Pigment Disorders (3) · The University of Texas Health Science Center, Houston (3) · Wake Forest University Health Sciences (3) · Cork University Hospital (2) · Icahn School of Medicine at Mount Sinai (2) · Indiana University (2) · Pontificia Universidad Catolica de Chile (2) · Regionshospitalet Silkeborg (2) · Stanford University (2) · University of Iowa (2) · University of North Carolina, Chapel Hill (2) · ALK Nordic A/S, Danmark Filial (1) · Aga Khan University (1) · Ain Shams Maternity Hospital (1)
United States (40) · Canada (6) · Denmark (4) · Norway (4) · Brazil (3) · Netherlands (3) · Pakistan (3) · Spain (3) · Turkey (Türkiye) (3) · Chile (2) · Egypt (2) · France (2) · Ireland (2) · Saudi Arabia (2) · South Korea (2)
Albert Wolkerstorfer, MD, PhD (3) · Daniel Katz, MD (2) · Daryl S Henshaw, MD (2) · Menno A. De Rie, MD, PhD (2) · Adnan Bayram, MD (1) · Alfonso Leon Garcia (1) · Alfredo E Hoyos, MD (1) · Amr H Yhia, M.D, MRCOG (1) · Anahi Perlas, MD (1) · Andrea Araneda, MD (1) · Asita de Silva (1) · Basak Ceyda Meco, MD, DESA (1) · Brian M Ilfeld, MD, MS (1) · Chandra Ramamoorthy, MD (1)
PMID 15572968, PMID 17589623, PMID 18596271, PMID 18830553, PMID 20646715, PMID 20736233, PMID 20835569, PMID 21196862, PMID 21572992, PMID 21809720, PMID 22004267, PMID 22440381, PMID 22459932, PMID 22480207, PMID 22579125, PMID 22694845, PMID 22929242, PMID 24344111, PMID 24678064, PMID 24702239, PMID 24706022, PMID 25955349, PMID 26349843, PMID 26535092, PMID 26655803, PMID 27144689, PMID 28445354, PMID 28538371, PMID 29077615, PMID 29088038, PMID 29315129, PMID 29346228, PMID 29406180, PMID 29600482, PMID 29753264, PMID 29943508, PMID 30203440, PMID 30234517, PMID 30236246, PMID 31671251, PMID 31999469, PMID 32934619, PMID 33575000, PMID 33601948, PMID 34391560, PMID 34759690, PMID 34896443, PMID 35000456, PMID 35100752, PMID 35139802
2014 (3), UL1TR000135 (2), 2008 (1), 2009 (1), 2017 (1)