105 completed, 22 unknown, 14 recruiting, 12 terminated. 169 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 169 | Completed 105, Unknown 22, Recruiting 14, Terminated 12, Withdrawn 8, Not yet recruiting 6, Active not recruiting 2 |
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Cost-Effectiveness of Upfront Supplemental Anaesthesia in Symptomatic Irreversible Pulpitis Inferior Alveolar Nerve Block With 2% Lidocaine With 1:80,000 Adrenaline, Upfront Buccal Infiltration With 4% Articaine With 1:100,000 Adrenaline, Upfront Intraligamentary Injection With 2% Lidocaine With 1:80,000 Adrenaline - Irreversible Pulpitis, Anesthesia, Local | Phase 4 | Not yet recruiting | Jamia Millia Islamia | 234 | 2026-10-30 | 2026-10-30 |
| Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department Adrenaline, 0.9 % sodium chloride - Peri-intubation Hypotension | Phase 4 | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 128 | 2026-06-01 | 2026-06-10 |
| Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition 5 mL of 0.25% bupivacaine with epinephrine (1:200,000), Placebo (Saline) Control - Autonomic Dysfunction | Phase 4 | Recruiting | University Health Network, Toronto | 78 | 2026-05-19 | 2026-10-09 |
| Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000 - Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block | Phase 4 | Completed | Rehman Medical Institute - RMI | 50 | 2026-03-03 | 2026-10-09 |
| Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic Surgery ropivacaine, lidocaine, lidocaine with epinephrine - Postoperative Pain, Upper Extremity Fracture | Phase 4 | Completed | Instituto Mexicano del Seguro Social | 138 | 2026-03-02 | 2026-10-30 |
| Study Comparing Glycerin With 1% Lidocaine and Epinephrine Versus Glycerin With 1% Lidocaine Without Epinephrine for the Sclerotherapy of Leg Telangiectasias Right leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine, Left leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine - Leg Veins | Phase 4 | Not yet recruiting | Goldman, Butterwick, Fitzpatrick and Groff | 20 | 2026-02-01 | 2026-01-15 |
| Bicarbonate Addition to Lidocaine-Epinephrine in Surgery Under WALANT Ambulatory surgery under Lidocaine with epinephrine alone, Ambulatory surgery under lidocaine with epinephrine plus bicarbonate - Anesthesia, Local, Hand Surgery | Phase 4 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 150 | 2026-02-01 | 2026-01-15 |
| Steroid Use in Treatment of Allergic Reactions to Food Antihistamines, Systemic corticosteroids, Adrenaline (rescue medication) - Anaphylactic Reaction, Anaphylaxis | Phase 4 | Recruiting | Johannes Trueck | 160 | 2026-01-26 | 2026-01-27 |
| Anesthetic Effectiveness of Lidocaine Versus Articaine in Dentistry lidocaine + epinephrine 1:100,000, Articaine 4% with epinephrine 1:100,000 - Dental Pain | Phase 4 | Not yet recruiting | Universidad Austral de Chile | 100 | 2025-12-20 | 2025-11-17 |
| The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery low-dose epinephrine and tranexamic acid, Tranexamic Acid (TXA) treatment - Knee Arthroplasty, Total, Knee Arthritis, Osteoarthritis | Phase 4 | Recruiting | King Abdullah International Medical Research Center | 80 | 2025-07-15 | 2025-07-28 |
| Study Evaluating the Safety and Efficacy of Neffy or Intramuscular Adrenalin in Patients With Allergic Reactions After Oral Food Challenge or Allergen Immunotherapy Neffy, Adrenaline - Allergic Reactions | Phase 4 | Recruiting | ARS Pharmaceuticals, Inc. | 600 | 2025-05-20 | 2026-04-21 |
| The PAIN (Pelvic Area Injection for Numbness) Study Bupivacaine, Epinephrine, Sham normal saline arm - Vaginal Laceration During Delivery | Phase 4 | Terminated | Montefiore Medical Center | 3 | 2025-04-08 | 2026-05-27 |
| Split Face Study of the Duration of Local Anesthetics - Fourth Arm 0.5 ml lidocaine + epinephrine 1:100,000, 1.0 ml lidocaine + epinephrine 1:100,000 - Anesthesia, Local | Phase 4 | Recruiting | Weill Medical College of Cornell University | 35 | 2025-01-21 | 2026-01-22 |
| Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy Patients Scalp nerve block, Morphine, Lidocaine - Supratentorial Tumors | Phase 4 | Completed | Aga Khan University | 62 | 2025-01-01 | 2026-02-23 |
| Effects Of Intra-Operative Intra-Articular Cocktail Injection In Patella Open Reduction And Internal Fixation Ketorolac 15mg, Triamcinolone Acetonide 40mg, Ropivacaine HCL 1% 15ml - Patella Fracture | Phase 4 | Recruiting | The University of Hong Kong | 56 | 2024-11-01 | 2025-06-05 |
| Lidocaine Versus Bupivacaine in Orthognathic Surgery 10 cc of 0.25% bupivacaine hydrochloride with 1:200,000 epinephrine, 6.8 cc of 2% lidocaine hydrochloride with 1:100,000 epinephrine - Pain, Postoperative, Numbness | Phase 4 | Completed | Boston Children's Hospital | 64 | 2024-10-01 | 2026-08-04 |
| Intrathecal Dexmedetomidine vs Epinephrine Dexmedetomidine, Epinephrine, Standardized Spinal Mixture - Cesarean Section, Anesthesia, Spinal | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 90 | 2024-09-17 | 2026-06-17 |
| Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia 2% Mepivacaine with 1:100,000 epinephrine, 2% Mepivacaine with 1:55,000 Epinephrine Bitartrate - Hemodynamics, Pain | Phase 4 | Completed | King Abdulaziz University | 52 | 2024-02-10 | 2025-06-12 |
| Multifidus Cervicis Plane Block Vs. Sham Block For Posterior Cervical Spine Fusion Surgery Bupivacaine Hcl 0.25% Inj, Normal saline - Cervical Spine Fusion | Phase 4 | Recruiting | Hartford Hospital | 38 | 2023-12-12 | 2025-09-05 |
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Pain, Postoperative (27) · Pain (17) · Agnosia (11) · Osteoarthritis, Knee (7) · Osteoarthritis (5) · Acute Pain (3) · Anaphylaxis (3) · Bronchiolitis (3) · Cataract (3) · Heart Arrest (2) · Hemorrhage (2) · Hip Dislocation (2) · Hypotension (2) · Lacerations (2) · Osteoarthritis, Hip (2)
Netherlands Institute for Pigment Disorders (4) · Wake Forest University Health Sciences (4) · Hartford Hospital (3) · Indiana University (3) · Mayo Clinic (3) · The University of Texas Health Science Center, Houston (3) · Assaf-Harofeh Medical Center (2) · Beijing Tiantan Hospital (2) · Cork University Hospital (2) · Icahn School of Medicine at Mount Sinai (2) · Milton S. Hershey Medical Center (2) · Oslo University Hospital (2) · Pontificia Universidad Catolica de Chile (2) · Regionshospitalet Silkeborg (2) · Seoul National University Hospital (2)
United States (67) · Canada (10) · Denmark (5) · Norway (5) · Brazil (4) · Egypt (4) · Netherlands (4) · South Korea (4) · Turkey (Türkiye) (4) · Chile (3) · China (3) · France (3) · Israel (3) · Pakistan (3) · Saudi Arabia (3)
Albert Wolkerstorfer, MD, PhD (4) · Menno A. De Rie, MD, PhD (3) · Anton Bermont, MD (2) · Daniel Katz, MD (2) · Daryl S Henshaw, MD (2) · Kevin Finkel, MD (2) · Kira Minkis, MD, PhD (2) · Adnan Bayram, MD (1) · Afua Gyamfi, MD (1) · Albatool Baroom (1) · Alfonso Leon Garcia (1) · Alfredo E Hoyos, MD (1) · Ali Shariat, MD (1) · Amr H Yhia, M.D, MRCOG (1)
PMID 10422923, PMID 15051743, PMID 15572968, PMID 16320034, PMID 16554198, PMID 16929992, PMID 17403800, PMID 17589623, PMID 17670879, PMID 18596271, PMID 18830553, PMID 18983373, PMID 19294964, PMID 20069307, PMID 20646715, PMID 20736233, PMID 20835569, PMID 21196862, PMID 21294923, PMID 21572992, PMID 21809720, PMID 21812940, PMID 22004267, PMID 22227789, PMID 22285545, PMID 22440381, PMID 22459932, PMID 22480207, PMID 22579125, PMID 22694845, PMID 22929242, PMID 23758233, PMID 23951692, PMID 24281921, PMID 24344111, PMID 24678064, PMID 24702239, PMID 24706022, PMID 24793570, PMID 24815964, PMID 24938586, PMID 25955349, PMID 26321593, PMID 26349843, PMID 26508124, PMID 26535092, PMID 26655803, PMID 26868800, PMID 27144689, PMID 28186223
2014 (3), UL1TR000135 (2), 2008 (1), 2009 (1), 2017 (1), 2023 (1)