179 completed, 31 unknown, 18 terminated, 15 recruiting. 77 Phase 3, 77 Phase 4, 45 Not applicable, 45 Phase 2, 12 Phase 1.
Follow Duloxetine: new trials by email Literature Review of Duloxetine trials Research Report on Duloxetine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 102 | 2027-03-01 | 2026-06-16 |
| Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy | Phase 2 | Not yet recruiting | Assiut University | 56 | 2026-11-01 | 2026-10-20 |
| Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance Duloxetine, Placebo - Knee Osteoarthritis (Knee OA), Chronic Pain | Phase 4 | Recruiting | Benedict Alter | 85 | 2026-09-15 | 2026-10-21 |
| Efficacy and Safety of Low-Dose Duloxetine Plus Alpha-Lipoic Acid Versus Standard-Dose Duloxetine in Painful Diabetic Peripheral Neuropathy Duloxetine, Alpha-Lipoic Acid - Painful Diabetic Peripheral Neuropathy | Not applicable | Not yet recruiting | Bangladesh Medical University | 170 | 2026-08-25 | 2026-08-26 |
| Algorithm-informed Decision-making to Advance Pain Treatment Algorithmically informed randomization (taking into account phenotypes), Physical Therapy (PT) and Exercise, Cognitive-Behavioral Therapy for Pain (PRISM-CBT) - Chronic Low-back Pain | Not applicable | Recruiting | University of Michigan | 500 | 2026-07-23 | 2026-09-15 |
| Duloxetine in Inflammatory Bowel Diseases Duloxetine - Inflammatory Bowel Diseases | Phase 2 | Recruiting | University of Pennsylvania | 32 | 2026-05-01 | 2026-07-16 |
| Impact of Virtual Reality Pelvic Floor Training on Postpartum Stress Urinary Incontinence Pelvic floor muscle rehabilitation supported by an immersive VR, Medical treatment - Stress Urinary Incontinence | Not applicable | Not yet recruiting | Cairo University | 50 | 2026-03-10 | 2026-03-06 |
| The Effect of Peppermint Oil Aromatherapy on Pain, Functional Capacity and Cost in Fibromyalgia Patients Peppermint Oil, sweet almond oil, Duloxetine - Fibromyalgia, Aromatherapy | Not applicable | Enrolling by invitation | Bilecik Seyh Edebali Universitesi | 175 | 2026-03-01 | 2026-09-17 |
| SPENDD: Quantitative Sensory Testing and Analgesic Response for Painful Peripheral Neuropathy. Pregabalin, Duloxetine, Placebo - Painful Peripheral Neuropathy, Diabetic Peripheral Neuropathic Pain (DPN) | Phase 2 | Recruiting | University of Rochester | 190 | 2026-02-02 | 2026-09-16 |
| Methadone to Treat Painful Chemotherapy Induced Peripheral Neuropathy methadone, duloxetine - Chemotherapy-induced Peripheral Neuropathy | Phase 2 / Phase 3 | Recruiting | University of British Columbia | 50 | 2025-03-21 | 2025-03-27 |
| Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis Duloxetine, Placebo capsule - Biliary Disease | Phase 3 | Recruiting | Tanta University | 44 | 2025-03-10 | 2026-08-18 |
| Duloxetine for Perioperative Pain in Hip Arthroplasty: A RCT Duloxetine, Placebo - THA | Phase 4 | Recruiting | University of Miami | 64 | 2025-03-01 | 2026-03-18 |
| Comparison of the Efficacy and Safety of Mirogabalin and Duloxetine in Chemotherapy-induced Peripheral Neuropathy in a Randomized Controlled Trial: a Quality of Life Study in Cancer Survivors Mirogabalin, Duloxetine - CIPN, CIPN - Chemotherapy-Induced Peripheral Neuropathy | Not applicable | Completed | Pusan National University Yangsan Hospital | 66 | 2024-12-01 | 2026-08-26 |
| Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE) Duloxetine, Placebo - Knee Osteoarthritis | Phase 4 | Recruiting | Sunnybrook Health Sciences Centre | 150 | 2024-11-01 | 2026-08-12 |
| Duloxetine to Prevent Chronic Postsurgical Pain After Inguinal Hernia Repair in Patients at High Risk Duloxetine, Placebo - Chronic Post-surgical Pain | Phase 3 | Active not recruiting | Parc de Salut Mar | 294 | 2024-09-03 | 2024-09-20 |
| ADC-induced Neurotoxicity Treated With Duloxetine duloxetine - Solid Tumour | Phase 2 | Unknown | Fudan University | 37 | 2024-08-06 | 2024-09-19 |
| Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route duloxetine - Vaginal Hysterectomy, Postoperative Pain | Not applicable | Completed | Erzincan Military Hospital | 80 | 2024-05-20 | 2025-01-22 |
| Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis Duloxetine, Celecoxib, Placebo - Knee Osteoarthritis | Phase 4 | Recruiting | Northwestern University | 180 | 2024-02-26 | 2026-04-30 |
| Patient Education and Duloxetine, Alone and in Combination, for Patients With Multisystem Functional Somatic Disorder Patient Education, Duloxetine, Benztropine Mesylate 0.5 MG and passive placebo RAP - Functional Disorder | Phase 4 | Recruiting | Aarhus University Hospital | 424 | 2024-01-01 | 2024-01-30 |
| Capsaicin 179 mg Patch Versus Oral Duloxetine in Patients With Chemotherapy-induced Peripheral Neuropathy Capsaicin, Duloxetine - Chemotherapy-induced Peripheral Neuropathy | Phase 3 | Recruiting | Institut Cancerologie de l'Ouest | 274 | 2023-10-20 | 2026-03-31 |
Showing 20 of 264. Sign in to see all of them.
Depressive Disorder, Major (60) · Depression (48) · Pain (24) · Fibromyalgia (16) · Urinary Incontinence, Stress (14) · Anxiety Disorders (12) · Osteoarthritis, Knee (12) · Pain, Postoperative (10) · Depressive Disorder (9) · Diabetic Neuropathies (8) · Osteoarthritis (8) · Chronic Pain (7) · Neuralgia (7) · Mood Disorders (6) · Back Pain (5)
Eli Lilly and Company (63) · Rambam Health Care Campus (7) · New York State Psychiatric Institute (6) · Assiut University (5) · H. Lundbeck A/S (5) · Massachusetts General Hospital (5) · AstraZeneca (4) · Northwestern University (4) · Stanford University (4) · Takeda (4) · University of Cincinnati (4) · Sunnybrook Health Sciences Centre (3) · University of Maryland, Baltimore (3) · AbbVie (prior sponsor, Abbott) (2) · Beijing Tiantan Hospital (2)
United States (128) · Canada (30) · France (18) · Germany (17) · China (16) · United Kingdom (16) · Egypt (11) · Mexico (11) · Puerto Rico (11) · Australia (10) · Israel (9) · Russia (9) · Poland (8) · South Korea (8) · Sweden (8)
Daniel Clauw, MD (3) · Afton Hassett, PsyD (2) · David Yarnitsky, Professor (2) · Lorrin M Koran (2) · Wolfram Nothaft, MD (2) · Afaf Mohamed Mahmoud, PhD (1) · Alan M Rathbun, PhD MPH (1) · Alexander Neumeister, MD (1)
PMID 24650448, PMID 31505082, PMID 21102344, PMID 25080392, PMID 36269595, PMID 31087825, PMID 31818787, PMID 32242018, PMID 18635722, PMID 21312349, PMID 22133624, PMID 22249355, PMID 23497790, PMID 24067192, PMID 24563781, PMID 24816198, PMID 25978741, PMID 26474010, PMID 27780334, PMID 27788130, PMID 35788366, PMID 36708956, PMID 10740540, PMID 16845641, PMID 17288694, PMID 17414743, PMID 17474806, PMID 17503986, PMID 17541049, PMID 17559726, PMID 17559729, PMID 17559755, PMID 17588276, PMID 17590215, PMID 18204338, PMID 18221532, PMID 18251622, PMID 18312043, PMID 18395345, PMID 18564199, PMID 18615176, PMID 19193344, PMID 19210951, PMID 19228176, PMID 19358790, PMID 19358791, PMID 19369473, PMID 19548294, PMID 19552867, PMID 19637208
1UG3AR077360-01 (1), 1UG3NR019196-01 (1), 2004 (1), 2005 (1), 2008 (1), 2009 (1), 2017 (1), 2018 (1), 2023 (1), K01AG064041 (1), K23MH099097 (1), K23NS123429 (1), P50MH077083 (1), R01DA047391 (1), R01MH043832 (1)