10 completed. 10 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 10 |
| Phase 2 | 2 | Completed 2 |
Follow Codeine: new trials by email Literature Review of Codeine trials Research Report on Codeine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions Oral metformin, Intravenous metformin, Oral codeine and oral metformin - Metformin, Organic Cation Transporter 1 | Phase 1 | Completed | University of Southern Denmark | 228 | 2018-03-01 | 2020-06-25 |
| E7 TCR T Cells for Human Papillomavirus-Associated Cancers E7 TCR cells, Aldesleukin, Fludarabine - Papillomavirus Infections, Cervical Intraepithelial Neoplasia | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 224 | 2017-01-27 | 2026-03-09 |
| Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects Naloxegol, Codeine, codeine placebo - Constipation Drug Induced | Phase 1 | Completed | Michael Camilleri | 72 | 2016-07-01 | 2017-08-30 |
| Codeine Phosphate/Guaifenesin ER Tablet 30 mg/600 mg Steady State Clinical Study Codeine Phosphate/Guaifenesin ER Tablet, Codeine Phosphate/Guaifenesin IR Tablet - Cough | Phase 1 | Completed | Nexgen Pharma, Inc | 38 | 2014-10-01 | 2017-03-29 |
| Single Dose Trial of Extended Release Combination Tablet Codeine and Guaifenesin IR Tablet under Fasted conditions, ER Tablet under Fed Conditions, ER Tablet under Fasted Conditions - Cough | Phase 1 | Completed | Nexgen Pharma, Inc | 26 | 2014-06-01 | 2015-04-15 |
| Open Label Study for the Functional Characterization of Drug Metabolism and Transport Codeine, Midazolam, pravastatin - Genotype-related Drug Metabolism | Phase 1 | Completed | Matthias Schwab | 144 | 2012-01-01 | 2015-05-27 |
| Repeated Dose Study for the Investigation of Heritability of and Genetic Influences on Drug Pharmacokinetics Codeine, Midazolam, Pravastatin - Drug Biotransformation, Membrane Transport | Phase 1 | Completed | Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH | 117 | 2009-12-01 | 2014-04-21 |
| Codeine in Mechanically Ventilated Neonates Codeine - Mechanically Ventilated Neonates, Painful Procedures in Newborns | Phase 1 | Completed | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | 6 | 2008-08-01 | 2018-08-27 |
| Study Evaluating the Potential of DVS SR to Inhibit the CYP2D6 Pathway desvenlafaxine sustained release (DVS SR), Paroxetine, Codeine - Depressive Disorder, Major, Diabetic Neuropathies | Phase 1 | Completed | Wyeth is now a wholly owned subsidiary of Pfizer | 40 | 2007-01-01 | 2007-12-28 |
| Codeine in Sickle Cell Disease Codeine (30 mg) - Sickle Cell Disease | Phase 1 / Phase 2 | Completed | PriCara, Unit of Ortho-McNeil, Inc. | 60 | 2005-03-01 | 2011-06-30 |
Cough (2) · Anemia, Sickle Cell (1) · Carcinoma in Situ (1) · Depressive Disorder, Major (1) · Diabetic Neuropathies (1) · Fibromyalgia (1) · Pain (1) · Papillomavirus Infections (1) · Uterine Cervical Dysplasia (1) · Vulvar Diseases (1) · Vulvar Neoplasms (1)
Nexgen Pharma, Inc (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH (1) · Matthias Schwab (1) · Michael Camilleri (1) · National Cancer Institute (NCI) (1) · PriCara, Unit of Ortho-McNeil, Inc. (1) · University of Southern Denmark (1) · Wyeth is now a wholly owned subsidiary of Pfizer (1)
United States (4) · Germany (2) · Jordan (2) · Denmark (1)
Jacob V Aranda, MD, PhD (1) · Matthias Schwab, Prof., M.D. (1) · Michael Camilleri, MD (1) · Rana T Bustami, PhD (1) · Scott M Norberg, D.O. (1) · Stacy S. Shord, PharmD (1)
PMID 26344676, PMID 27825374, PMID 32973880, PMID 33558725
UL1TR000135 (1)