8 completed, 2 terminated. 10 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Terminated 2 |
| Phase 2 | 1 | Completed 1 |
Follow Codeine: new trials by email Literature Review of Codeine trials Research Report on Codeine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fixed Combination of Dipyrone and Codeine for Controlling Pain After Pelvic-abdominal Surgery Fixed dose combination Dipyrone and Codeine, Dipyrone, Codeine - Pain, Postoperative | Phase 3 | Completed | Brazilian Clinical Research Institute | 491 | 2023-03-16 | 2026-05-11 |
| COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA Lacosamide 50 MG Oral Tablet [Vimpat], Codeine Phosphate, Diclofenac Sodium - Sciatica Acute, Sciatica | Phase 3 | Completed | Pakistan Institute of Medical Sciences | 120 | 2021-09-28 | 2022-11-23 |
| Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain Codeine, paracetamol, placebo - Myopia | Phase 3 | Completed | University of Sao Paulo General Hospital | 40 | 2014-11-01 | 2015-12-11 |
| A Study of Oral Codeine Sulfate in Pediatric Patients With Post-procedural Pain Codeine - Pain | Phase 3 | Terminated | Roxane Laboratories | 31 | 2012-04-01 | 2018-10-02 |
| Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge Hydrocodone (first trial), Codeine (first trial), Oxycodone (for second trial) - Analgesia After ED Discharge for Extremity Injuries | Phase 3 | Completed | Montefiore Medical Center | 720 | 2012-01-01 | 2018-05-01 |
| Idiopathic Intracranial Hypertension Treatment Trial Acetazolamide, Placebo, Formal weight loss counselling program - Idiopathic Intracranial Hypertension | Phase 2 / Phase 3 | Completed | St. Luke's-Roosevelt Hospital Center | 165 | 2010-01-01 | 2018-12-12 |
| Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study Ibuprofen/acetaminophen, Ibuprofen/acetaminophen (higher dose), Nurofen Plus® - Post-operative Pain | Phase 3 | Completed | Reckitt Benckiser LLC | 678 | 2009-01-01 | 2018-09-17 |
| A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092) Comparator: etoricoxib, Comparator: ibuprofen, Comparator: acetaminophen + codeine - Postoperative Dental Pain | Phase 3 | Completed | Organon and Co | 588 | 2008-06-01 | 2022-02-09 |
| T3AI-Pain After Breast Surgery acetaminophen plus codeine, acetaminophen plus ibuprofen - Pain, Breast Diseases | Phase 3 | Completed | Nova Scotia Health Authority | 150 | 2006-05-01 | 2009-02-02 |
| Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy ondansetron, ibuprofen, paracetamol, Ondansetron, ibuprofen, paracetamol, metoclopramide, ibuprofen, paracetamol - HIV Infections | Phase 3 | Terminated | Kirby Institute | 28 | 2005-11-01 | 2012-04-12 |
Pain (4) · Agnosia (3) · Pain, Postoperative (2) · Breast Diseases (1) · Diplopia (1) · HIV Infections (1) · Headache (1) · Myopia (1) · Obesity (1) · Papilledema (1) · Pseudotumor Cerebri (1) · Sciatica (1) · Tinnitus (1) · Toothache (1) · Vision Disorders (1)
Brazilian Clinical Research Institute (1) · Kirby Institute (1) · Montefiore Medical Center (1) · Nova Scotia Health Authority (1) · Organon and Co (1) · Pakistan Institute of Medical Sciences (1) · Reckitt Benckiser LLC (1) · Roxane Laboratories (1) · St. Luke's-Roosevelt Hospital Center (1) · University of Sao Paulo General Hospital (1)
United States (4) · Brazil (2) · Canada (2) · Argentina (1) · Australia (1) · Israel (1) · Pakistan (1)
Alex D Mitchell, MD (1) · Andrew Chang, MD (1) · Dante Landucci, MD (1) · Michael Wall, MD (1) · Samir Bechara, MD (1) · Sarah L Pett, M.D (1) · Stephen Daniels (1)
PMID 23247002, PMID 24756302, PMID 24756514, PMID 24781936, PMID 25370510, PMID 25370513, PMID 26024112, PMID 26335066, PMID 26618282, PMID 26778344, PMID 26934136, PMID 27694262, PMID 28130349, PMID 28492874, PMID 28820793, PMID 33470341
U10EY017281 (1), U10EY017387 (1)