15 completed, 1 unknown, 1 withdrawn. 17 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 17 | Completed 15, Unknown 1, Withdrawn 1 |
Follow Codeine: new trials by email Literature Review of Codeine trials Research Report on Codeine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CHAO Tos: Codeina, HederA Helix, LevOdropropizina Para la TOS Codeine, Levodropropizine, Ivy Leaves Cough Liquid - Upper Resp Tract Infection | Phase 4 | Completed | Pontificia Universidad Catolica de Chile | 196 | 2025-05-13 | 2025-12-03 |
| Evaluation of the Analgesic Efficacy of the Combination of Dexketoprofen + Paracetamol and the Combination of Naproxen Sodium + Codeine in Patients With Acute Dental Pain Dexketoprofen Trometamol + Paracetamol, Naproxen Sodium + Codeine Phosphate - Acute Dental Pain | Phase 4 | Completed | ibrahim doğru | 100 | 2023-01-10 | 2025-04-08 |
| Colonic Motor Patterns in Healthy Volunteers Naloxegol, codeine phosphate, Placebo - Opioid-Induced Constipation | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 15 | 2018-06-27 | 2023-03-16 |
| Efficacy of Naproxen-codeine, Naproxen+Dexamethasone, and Naproxen on Myofascial Pain naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol - Temporomandibular Disorder | Phase 4 | Completed | Yuzuncu Yil University | 200 | 2018-03-01 | 2021-02-15 |
| Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery paracetamol 500 mg plus codeine 30 mg preoperative administration, ibuprofen 400 mg preoperative administration, Placebo oral tablet preoperative administration - To Control Pain After Third Molar Surgery | Phase 4 | Completed | University of Roma La Sapienza | 120 | 2018-01-01 | 2021-01-29 |
| Codeine on Pharyngeal and Esophageal Motility Codeine Phosphate, Siripus simplex - Esophageal Motility Disorders | Phase 4 | Completed | Universitaire Ziekenhuizen KU Leuven | 22 | 2017-09-07 | 2018-12-24 |
| Gabapentin for Pain Control After Osmotic Dilator Insertion and Prior to D&E Procedure: a Randomized Controlled Trial Gabapentin 600mg, Placebo oral capsule, acetaminophen/codeine and ibuprofen - Abortion, Induced, Cervical Preparation | Phase 4 | Completed | University of California, Davis | 121 | 2017-03-20 | 2020-04-14 |
| Postoperative Analgesia in Laminectomy 550 mg naproxen sodium and 30mg codeine, 300 mg paracetamol and 30 mg codeine, placebo tablet - Postoperative Pain, Postoperative Laminectomy Pain | Phase 4 | Unknown | Diskapi Yildirim Beyazit Education and Research Hospital | 75 | 2014-10-01 | 2014-12-30 |
| Effectiveness of Diclofenac and Its Association to Codeine After Lower Third Molar Extraction. Codeine + Diclofenac, Diclofenac - Impacted Third Molar Tooth | Phase 4 | Completed | University of Sao Paulo | 50 | 2014-09-01 | 2015-09-11 |
| Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain Oxycodone, Codeine - Postcraniotomy Pain | Phase 4 | Completed | Tan Tock Seng Hospital | 40 | 2012-07-01 | 2015-05-15 |
| A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy Codeine with acetaminophen, Tramadol suspension - Tonsillitis, Pain | Phase 4 | Completed | Children's Hospitals and Clinics of Minnesota | 84 | 2011-01-01 | 2014-04-17 |
| Effect of Methylnaltrexone on GI Transit in Healthy Volunteers Methylnaltrexone only, Codeine only, Methylnaltrexone + codeine - Gastric Motility Disorder | Phase 4 | Completed | Mayo Clinic | 48 | 2009-11-01 | 2012-06-25 |
| Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination Ibuprofen + Paracetamol, Ibuprofen + Paracetamol + Codeine, Paracetamol + Codeine - Pain, Postoperative | Phase 4 | Completed | Ullevaal University Hospital | 200 | 2009-06-01 | 2016-03-30 |
| Combined Analgesia to Control Pain in Children Seen in Emergency Department (ED) for a Trauma of a Limb ibuprofen and codeine - Trauma | Phase 4 | Completed | St. Justine's Hospital | 200 | 2008-02-01 | 2010-08-27 |
| Analgesic Effect of Ibuprofen, Paracetamol (Acetaminophen), and Paracetamol (Acetaminophen) Plus Codeine on Acute Pain Placebo, Ibuprofen 400 mg, Ibuprofen 600 mg - Surgery | Phase 4 | Completed | Ullevaal University Hospital | 350 | 2007-06-01 | 2011-07-06 |
| Assessment of Opioid Analgesia in Sickle Cell Dextromethorphan, Codeine, Morphine - Sickle Cell Disease | Phase 4 | Withdrawn | Children's National Research Institute | 2006-11-01 | 2014-12-23 | |
| Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain acetaminophen, codeine phosphate, dextropropoxyphene hydrochloride - Pain, Unspecified Adult Solid Tumor, Protocol Specific | Phase 4 | Completed | University Hospitals Bristol and Weston NHS Foundation Trust | 30 | 2004-01-01 | 2013-08-02 |
Pain (6) · Pain, Postoperative (2) · Agnosia (1) · Anemia, Sickle Cell (1) · Cough (1) · Esophageal Motility Disorders (1) · Opioid-Induced Constipation (1) · Respiratory Tract Infections (1) · Temporomandibular Joint Disorders (1) · Tonsillitis (1) · Wounds and Injuries (1)
Ullevaal University Hospital (2) · Universitaire Ziekenhuizen KU Leuven (2) · Children's Hospitals and Clinics of Minnesota (1) · Children's National Research Institute (1) · Diskapi Yildirim Beyazit Education and Research Hospital (1) · Mayo Clinic (1) · Pontificia Universidad Catolica de Chile (1) · St. Justine's Hospital (1) · Tan Tock Seng Hospital (1) · University Hospitals Bristol and Weston NHS Foundation Trust (1) · University of California, Davis (1) · University of Roma La Sapienza (1) · University of Sao Paulo (1) · Yuzuncu Yil University (1) · ibrahim doğru (1)
United States (4) · Belgium (2) · Norway (2) · Turkey (Türkiye) (2) · Canada (1) · Chile (1) · Italy (1) · Singapore (1)
Gaute Lyngstad, DDS (2) · Geoff Hanks, MD (1) · Jan Tack, Professor (1) · Julia C. Finkel, M.D. (1) · Lasse A Skoglund, DDS, DSCi (1) · Lasse A Skoglund, DDS, DSci (1) · Maria Paola Cristalli, DDS, PhD (1) · Michael Camilleri, MD (1) · Mitchell Creinin, MD (1) · Natasha Schimmoeller, MD, MPH, MA (1) · Paulo Z Goncalves, DDS (1) · Per Skjelbred, MD, DDS, PhD (1) · Reyhan Polat, MD (1) · Stefan J Friedrichsdorf, M.D. (1) · Sylvie Le May, PhD (1)
PMID 20839388, PMID 32797734, PMID 33232555, PMID 34655316, PMID 34922726, PMID 37349498, PMID 41107344