4 active not recruiting, 4 recruiting, 2 completed, 1 not yet recruiting. 6 Phase 1, 3 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Recruiting 3, Active not recruiting 2, Not yet recruiting 1 |
| Phase 2 | 3 | Completed 2, Active not recruiting 1 |
| Phase 3 | 2 | Active not recruiting 1, Completed 1 |
Follow Yolk Sac Tumor: new trials by email Literature Review of Yolk Sac Tumor trials Research Report on Yolk Sac Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| Molecular Epidemiology of Pediatric Germ Cell Tumors Questionnaire Administration, Tumor Specimen Collection, Germline DNA Samples - Germ Cell Tumor, Germinoma | Recruiting | Children's Oncology Group | 1151 | 2023-04-12 | 2025-10-24 | |
| Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor Thalidomide combined with TGA chemotherapy (nab-paclitaxel + gemcitabine+ epirubicin) - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 | Completed | Shandong First Medical University | 20 | 2021-11-11 | 2025-09-18 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors AGAR T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Active not recruiting | Baylor College of Medicine | 14 | 2021-08-08 | 2026-01-21 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors CATCH T cells - Liver Cell Carcinoma, Solid Tumor | Phase 1 | Active not recruiting | Baylor College of Medicine | 12 | 2021-06-17 | 2026-03-06 |
| Clinical Study of Chemotherapy in the Treatment of Recurrent/Refractory Yolk Sac Tumor in Children sirolimus combined with chemotherapy in the treatment of recurrent/refractory yolk sac tumor in children - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 / Phase 3 | Completed | Shandong First Medical University | 32 | 2020-06-01 | 2025-09-19 |
| Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors paclitaxel, ifosfamide, cisplatin - Germ Cell Tumor, Teratoma | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 420 | 2015-08-06 | 2026-06-16 |
Endodermal Sinus Tumor (11) · Liposarcoma (6) · Rhabdomyosarcoma (6) · Liver Neoplasms (5) · Rhabdoid Tumor (5) · Wilms Tumor (5) · Carcinoma, Hepatocellular (4) · Neoplasms, Germ Cell and Embryonal (4) · Hepatoblastoma (3) · Choriocarcinoma (2) · Germinoma (2) · Teratoma (2) · Adrenal Gland Neoplasms (1) · Anus Neoplasms (1) · Biliary Tract Neoplasms (1)
Mesonephroma (11) · Neoplasms (11) · Neoplasms by Histologic Type (11) · Female Urogenital Diseases and Pregnancy Complications (8) · Urogenital Diseases (8) · Adenocarcinoma (7) · Carcinoma (7) · Digestive System Diseases (7) · Digestive System Neoplasms (7) · Neoplasms by Site (7) · Neoplasms, Connective and Soft Tissue (7) · Neoplasms, Germ Cell and Embryonal (7) · Neoplasms, Glandular and Epithelial (7) · Neoplasms, Muscle Tissue (7) · Female Urogenital Diseases (6)
130-nm albumin-bound paclitaxel (1) · Carboplatin (1) · Cisplatin (1) · Drug Therapy (1) · Etoposide (1) · Granulocyte Colony-Stimulating Factor (1) · Ifosfamide (1) · Nivolumab (1) · Paclitaxel (1) · etoposide phosphate (1)
Baylor College of Medicine (4) · Seattle Children's Hospital (2) · Shandong First Medical University (2) · Alliance for Clinical Trials in Oncology (1) · Children's Oncology Group (1) · Instituto do Cancer do Estado de São Paulo (1)
United States (8) · China (2) · Australia (1) · Belgium (1) · Brazil (1) · Denmark (1) · France (1) · Germany (1) · Ireland (1) · Italy (1) · Netherlands (1) · Spain (1) · Switzerland (1) · United Kingdom (1)
David Steffin, MD (3) · Jingfu Wang, MD (2) · Camila MV Moniz, Doctor (1) · Colleen Annesley (1) · Colleen Annesley, MD (1) · Corinne Summers (1) · Corinne Summers, MD (1) · Darren Feldman, MD (1) · Jenny Poynter, PhD (1) · Premal Lulla, MD (1) · Tannaz Armaghany, MD (1)
U10CA180821 (1)