35 completed, 6 recruiting, 4 active not recruiting, 2 unknown. 20 Phase 2, 14 Phase 3, 12 Phase 1, 4 Not applicable.
Follow Endodermal Sinus Tumor: new trials by email Literature Review of Endodermal Sinus Tumor trials Research Report on Endodermal Sinus Tumor
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cytokine Armored GPC3 Specific Chimeric Antigen Receptor Expressing T-cells in Adults With Solid Tumors SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Hepatocellular Carcinoma | Phase 1 | Not yet recruiting | Seattle Children's Hospital | 21 | 2026-04-01 | 2025-11-04 |
| Immunotherapy for Solid Tumor Malignancies in Pediatrics Using Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor T Cells SC-CAR.GPC3xIL15.21 CAR T cells - Solid Tumor (Excluding CNS), Liver Cell Carcinoma | Phase 1 | Recruiting | Seattle Children's Hospital | 21 | 2025-12-22 | 2026-02-17 |
| Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells 21.15.GPC3-CAR T cells - Hepatoblastoma, Hepatocellular Carcinoma | Phase 1 | Recruiting | Baylor College of Medicine | 21 | 2025-06-10 | 2025-11-03 |
| Agnostic Therapy in Rare Solid Tumors Nivolumab - Urachal Cancer, Parathyroid Carcinoma | Phase 2 | Active not recruiting | Instituto do Cancer do Estado de São Paulo | 28 | 2024-07-16 | 2026-10-13 |
| Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors CARE T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Recruiting | Baylor College of Medicine | 24 | 2024-05-24 | 2026-08-06 |
| High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) - Germ Cell Tumor | Phase 2 | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 25 | 2024-03-01 | 2025-08-03 |
| Molecular Epidemiology of Pediatric Germ Cell Tumors Questionnaire Administration, Tumor Specimen Collection, Germline DNA Samples - Germ Cell Tumor, Germinoma | Recruiting | Children's Oncology Group | 1151 | 2023-04-12 | 2025-10-24 | |
| Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor Thalidomide combined with TGA chemotherapy (nab-paclitaxel + gemcitabine+ epirubicin) - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 | Completed | Shandong First Medical University | 20 | 2021-11-11 | 2025-09-18 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors AGAR T cells - Liver Cancer, Rhabdomyosarcoma | Phase 1 | Active not recruiting | Baylor College of Medicine | 14 | 2021-08-08 | 2026-01-21 |
| Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors CATCH T cells - Liver Cell Carcinoma, Solid Tumor | Phase 1 | Active not recruiting | Baylor College of Medicine | 12 | 2021-06-17 | 2026-03-06 |
| Clinical Study of Chemotherapy in the Treatment of Recurrent/Refractory Yolk Sac Tumor in Children sirolimus combined with chemotherapy in the treatment of recurrent/refractory yolk sac tumor in children - Germ Cell Tumor, Yolk Sac Tumor | Phase 2 / Phase 3 | Completed | Shandong First Medical University | 32 | 2020-06-01 | 2025-09-19 |
| Role of Axumin PET Scan in Germ Cell Tumor Axumin PET scan - Testis Cancer, Germ Cell Tumor | Completed | University of Texas Southwestern Medical Center | 10 | 2018-03-01 | 2025-08-11 | |
| Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Best Practice, Biopsy Procedure, Biospecimen Collection - Childhood Extracranial Germ Cell Tumor, Extragonadal Embryonal Carcinoma | Phase 3 | Recruiting | Children's Oncology Group | 1780 | 2017-05-25 | 2026-08-25 |
| Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors paclitaxel, ifosfamide, cisplatin - Germ Cell Tumor, Teratoma | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 420 | 2015-08-06 | 2026-06-16 |
| DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings Laboratory Biomarker Analysis, Questionnaire Administration - Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor | Completed | Children's Oncology Group | 932 | 2011-11-01 | 2019-01-07 | |
| Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Carboplatin, Filgrastim, Ifosfamide - Childhood Extracranial Germ Cell Tumor, Childhood Extragonadal Malignant Germ Cell Tumor | Phase 2 | Completed | Children's Oncology Group | 20 | 2007-11-05 | 2018-08-29 |
| Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment sunitinib malate - Extragonadal Germ Cell Tumor, Ovarian Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 10 | 2007-03-01 | 2015-10-27 |
| Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors pegfilgrastim, cisplatin, ifosfamide - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 60 | 2007-03-01 | 2017-11-28 |
| Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors carboplatin, etoposide, ifosfamide - Childhood Germ Cell Tumor, Ovarian Cancer | Phase 2 | Completed | Masonic Cancer Center, University of Minnesota | 23 | 2006-12-19 | 2022-05-17 |
| Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors filgrastim, lenograstim, pegfilgrastim - Brain and Central Nervous System Tumors, Extragonadal Germ Cell Tumor | Phase 1 / Phase 2 | Unknown | University of Southampton | 23 | 2006-11-01 | 2013-01-23 |
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Teratoma (35) · Testicular Neoplasms (35) · Carcinoma, Embryonal (32) · Seminoma (29) · Testicular Germ Cell Tumor (23) · Teratoma, Testicular (20) · Carcinoma, Ovarian Epithelial (16) · Wilms Tumor (16) · Breast Neoplasms (15) · Neuroblastoma (15) · Burkitt Lymphoma (14) · Hodgkin Disease (14) · Leukemia, Lymphocytic, Chronic, B-Cell (14) · Lymphoma, Follicular (14)
Mesonephroma (49) · Neoplasms by Histologic Type (49) · Urogenital Diseases (44) · Neoplasms by Site (42) · Neoplasms, Germ Cell and Embryonal (42) · Male Urogenital Diseases (41) · Urogenital Neoplasms (41) · Neoplasms (40) · Endocrine Gland Neoplasms (36) · Endocrine System Diseases (36) · Genital Diseases (36) · Genital Diseases, Male (36) · Genital Neoplasms, Male (36) · Gonadal Disorders (36) · Testicular Diseases (35)
Cisplatin (13) · Etoposide (10) · Ifosfamide (10) · Paclitaxel (10) · Bleomycin (8) · Filgrastim (8) · Carboplatin (7) · Granulocyte Colony-Stimulating Factor (3) · Peripheral Blood Stem Cell Transplantation (3) · pegfilgrastim (3) · Cyclophosphamide (2) · Drug Therapy (2) · Magnetic Resonance Spectroscopy (2) · Radiotherapy (2) · Therapeutics (2)
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