37 completed, 17 recruiting, 8 active not recruiting, 7 unknown. 33 Phase 2, 15 Phase 3, 9 Not applicable, 7 Phase 1.
Follow Germinoma: new trials by email Literature Review of Germinoma trials Research Report on Germinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| China Treatment Trial for Tumor in Sellar Region With Unruptured Intracranial Aneurysm Tumor resection followed by aneurysm treatment, Aneurysm treatment followed by tumor resection, Observation - Unruptured Intracranial Aneurysms, Pituitary Neuroendocrine Tumor | Active not recruiting | Cheng sen | 608 | 2026-10-20 | 2026-10-21 | |
| PRISTINE Trial: PRoton Beam Therapy In Seminoma - Toxicity INvestigation and Evaluation of Outcome protontherapy - Seminoma | Not applicable | Not yet recruiting | Istituto Clinico Humanitas | 20 | 2026-05-01 | 2026-05-22 |
| Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors Vertebral Body-Sparing Craniospinal Proton Irradiation - Pediatric Central Nervous System Tumors, Medulloblastoma | Not yet recruiting | Ruijin Hospital | 38 | 2026-04-30 | 2026-05-15 | |
| Sentinel Node Identification Using Gamma and Near-Infrared Imaging in TesticulAr MaLignancies Standard treatment: orchiectomy followed by drug therapy and, if necessary, retroperitoneal lymphadenectomy, sentinel lymph node mapping using technetium-99m (Tc-99m) and indocyanine green (ICG) with subsequent orchiectomy - Germ Cell Tumor of Testis | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 60 | 2026-04-01 | 2026-08-27 | |
| Primary RPLND Versus Systemic Chemotherapy in Good-prognosis Metastatic Testicular Cancer primary RPLND for low-stage metasatatic seminoma, 3 courses of chemotherapy; Blemocin, Etoposide and Platinum (BEP) - Testicular Cancer, Seminoma | Not applicable | Recruiting | Sahlgrenska University Hospital | 160 | 2026-03-19 | 2026-03-27 |
| Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors Audiometric Test, Cisplatin, Computed Tomography - Hearing Loss, Metastatic Malignant Germ Cell Tumor | Phase 1 | Recruiting | City of Hope Medical Center | 44 | 2026-02-19 | 2026-04-17 |
| A Clinical Trial of Primary Retroperitoneal Lymph Node Dissection in Patients With Testicular Seminoma With Limited Retroperitoneal Metastases Retroperitoneal Lymph Node Dissection - Testicular Cancer | Phase 2 | Recruiting | Western University, Canada | 30 | 2025-07-17 | 2025-07-20 |
| A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma 3-Dimensional Conformal Proton Radiation Therapy, 3-Dimensional Conformal Radiation Therapy, Biospecimen Collection - Basal Ganglia Germinoma, Diabetes Insipidus | Phase 2 | Recruiting | Children's Oncology Group | 240 | 2024-10-22 | 2026-08-25 |
| THERApy De-escalation for TESTicular Cancer retroperitoneal lymph node dissection, Carboplatin AUC10 - Seminoma | Recruiting | Queen Mary University of London | 30 | 2024-06-24 | 2026-03-02 | |
| High-dose Chemotherapy as Second-line Drug Therapy for Relapsed Germ Cell Tumors High-dose chemotherapy (TI- 2 cycles, CE- 3 cycles ) - Germ Cell Tumor | Phase 2 | Recruiting | N.N. Petrov National Medical Research Center of Oncology | 25 | 2024-03-01 | 2025-08-03 |
| Assessment of Compliance With Monitoring Conducted by a Physician in Person or by a Nurse in Remote Monitoring Oncological Follow-up - Stage I Testicular Seminoma, Stage I Testicular Nonseminomatous Germ Cell Tumor | Phase 2 | Recruiting | Centre Oscar Lambret | 88 | 2024-02-28 | 2026-03-18 |
| Robot-assisted ICG-guided Sentinel Node Biopsy in Testicular Cancer Robot-assisted ICG-guided sentinel lymph node biopsy - Germ Cell Tumor, Seminoma | Not applicable | Recruiting | Heinrich-Heine University, Duesseldorf | 44 | 2023-09-06 | 2025-09-15 |
| Disorders of Sexual Development and Gonadal Tumor Risk Not applicable . Non-interventional retrospective study, only on datas. - Disorders of Sexual Development | Completed | Hospices Civils de Lyon | 80 | 2023-09-01 | 2025-04-13 | |
| PRIMETEST II - Clinical Stage II A/B Seminoma Treated With RA-RPLND Robot-assisted retroperitoneal lymph node dissection, Adjuvant therapy with one cycle of cisplatin, etoposide and bleomycin - Seminoma | Phase 2 | Recruiting | Heinrich-Heine University, Duesseldorf | 60 | 2023-08-28 | 2025-09-15 |
| Molecular Epidemiology of Pediatric Germ Cell Tumors Questionnaire Administration, Tumor Specimen Collection, Germline DNA Samples - Germ Cell Tumor, Germinoma | Recruiting | Children's Oncology Group | 1151 | 2023-04-12 | 2025-10-24 | |
| De-escalation Study for Stage IIa/IIb < 3 cm Seminoma Radiotherapy boost, Carboplatin AUC7, 3 cycles of EP - Seminoma, Stage II | Phase 2 | Recruiting | Centre Leon Berard | 90 | 2022-09-06 | 2026-09-15 |
| Development of Asian Consortium for Data Collection and Clinical Trial of CNS Tumors Radiation Therapy - CNS Germinoma, CNS Tumor | Recruiting | National Cancer Center, Korea | 400 | 2022-08-05 | 2023-08-08 | |
| R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma Robotic Retroperitoneal Lymph Node Dissection (RPLND) - Lymphadenopathy Retroperitoneal, Stage II Testicular Seminoma | Not applicable | Recruiting | University Health Network, Toronto | 25 | 2022-02-23 | 2025-12-19 |
| Radiotherapy vs Observation for Post Chemotherapy Residual Mass in Advanced Seminoma Radiotherapy - Seminoma | Not applicable | Recruiting | Tata Memorial Centre | 74 | 2021-12-01 | 2025-02-11 |
| A Phase II Trial of Cabozantinib With Patients With Refractory GCTs Cabozantinib - Germ Cell Tumor, Seminoma | Phase 2 | Completed | Jennifer King | 50 | 2021-06-10 | 2026-10-16 |
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Seminoma (62) · Testicular Neoplasms (40) · Endodermal Sinus Tumor (30) · Teratoma (28) · Carcinoma, Embryonal (26) · Testicular Germ Cell Tumor (21) · Teratoma, Testicular (18) · Carcinoma, Ovarian Epithelial (16) · Breast Neoplasms (15) · Burkitt Lymphoma (14) · Hodgkin Disease (14) · Leukemia, Lymphocytic, Chronic, B-Cell (14) · Lymphoma, Follicular (14) · Lymphoma, Large B-Cell, Diffuse (14) · Lymphoma, Large-Cell, Immunoblastic (14)
Neoplasms by Histologic Type (76) · Neoplasms, Germ Cell and Embryonal (66) · Neoplasms (65) · Neoplasms by Site (51) · Urogenital Diseases (50) · Endocrine System Diseases (49) · Endocrine Gland Neoplasms (46) · Gonadal Disorders (46) · Genital Diseases (45) · Urogenital Neoplasms (45) · Male Urogenital Diseases (44) · Genital Diseases, Male (41) · Genital Neoplasms, Male (41) · Testicular Diseases (40)
Etoposide (13) · Cisplatin (12) · Carboplatin (11) · Paclitaxel (8) · Bleomycin (7) · Filgrastim (7) · Ifosfamide (7) · Radiotherapy (6) · Magnetic Resonance Spectroscopy (5) · Cyclophosphamide (3) · Peripheral Blood Stem Cell Transplantation (3) · pegfilgrastim (3) · CTLA-4 Antigen (2) · Granulocyte Colony-Stimulating Factor (2) · Imatinib Mesylate (2)
Fred Hutchinson Cancer Center (7) · Memorial Sloan Kettering Cancer Center (6) · National Cancer Institute (NCI) (5) · European Organisation for Research and Treatment of Cancer - EORTC (4) · Children's Oncology Group (3) · Alliance for Clinical Trials in Oncology (2) · City of Hope Medical Center (2) · Harry T Whelan, MD (2) · Heinrich-Heine University, Duesseldorf (2) · Medical Research Council (2) · N.N. Petrov National Medical Research Center of Oncology (2) · Swiss Cancer Institute (2) · AHS Cancer Control Alberta (1) · Barts & The London NHS Trust (1) · Cambridge University Hospitals NHS Foundation Trust (1)
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Robert J. Motzer, MD (4) · Alexandros Papachristofilou, MD (2) · Darren Feldman, MD (2) · Harry T Whelan, MD (2) · A Mendez Romero (1) · Aleksei M Belyaev, MD,DSc,Prof. (1) · Alex Chehrazi-Raffle (1) · Anastasios Raptis, MD (1) · Christopher Ryan (1) · Claude Sportes, MD (1) · Craig R Nichols (1) · Danielle Eekers (1) · David Hockenbery, MD (1)
PMID 15459300, PMID 16039331, PMID 16849762, PMID 17235042, PMID 17634488, PMID 18728566, PMID 18974373, PMID 19451433, PMID 19547919, PMID 19706807, PMID 21059637, PMID 21282539, PMID 22752346, PMID 23845268, PMID 30563754, PMID 31136925, PMID 31969335, PMID 32502506, PMID 33362722, PMID 33882143, PMID 34380663, PMID 34716198, PMID 35298280, PMID 35599187, PMID 36228644, PMID 36913642, PMID 38243705, PMID 38358334, PMID 38875730, PMID 39028926, PMID 39067873, PMID 39343510, PMID 39417692, PMID 39583952, PMID 39649870, PMID 39856213, PMID 40203124, PMID 40402690, PMID 40588371, PMID 41672597, PMID 41823372, PMID 41892875, PMID 41995270, PMID 42499790
P30CA033572 (2), U10CA031946 (2), 2009 (1), 2014 (1), 2019 (1), P30CA008748 (1), P30CA014089 (1), R01CA093891 (1), U10CA101165 (1), U10CA180821 (1), U10CA180886 (1), U10CA180888 (1), UG1CA189974 (1)