7 completed, 3 unknown, 2 not yet recruiting, 2 recruiting. 10 Not applicable, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 5, Not yet recruiting 2, Unknown 2, Recruiting 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow Work of Breathing: new trials by email Literature Review of Work of Breathing trials Research Report on Work of Breathing
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Role of Environmental Temperatures in Respiratory Control Thermoneutral temperature environment, Cold temperature environment, Hot temperature environment - Work of Breathing | Not applicable | Not yet recruiting | Indiana University | 15 | 2028-10-01 | 2026-03-13 |
| The Role of Breathing Perception in Respiratory Control Ambient Noise, Increased Auditory Feedback, Noise Distraction - Work of Breathing | Not applicable | Not yet recruiting | Indiana University | 15 | 2027-06-01 | 2026-03-13 |
| The Role of Heliox in Respiratory Control Heliox inspirate - Work of Breathing | Phase 4 | Recruiting | Indiana University | 15 | 2026-02-03 | 2026-03-12 |
| INSPIRatory Efforts Estimation Under High-flow Nasal Oxygen Non-invasive estimation of inspiratory effort - Oxygen, Respiratory Insufficiency | Not applicable | Completed | Poitiers University Hospital | 20 | 2025-11-29 | 2026-05-22 |
| Proportional Assist Ventilation Plus and Estimation of Respiratory Effort During the Transition to Spontaneous Ventilation Application of Proportional Assist Ventilation Plus (PAV+) at three support levels (20%, 50%, 70%) to assess ventilator-displayed work of breathing and its correlation with physiologic measures. - Respiratory Effort, Proportional Assist Ventilation | Active not recruiting | Argentinian Intensive Care Society | 35 | 2024-02-01 | 2025-06-08 | |
| Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA NAVA GROUP - Work of Breathing, Lung Transplantation | Not applicable | Recruiting | University of Padova | 40 | 2022-12-27 | 2025-07-08 |
| Work of Breathing in Term Infants Work of breathing observation - Work of Breathing, Term Infant | Completed | Christiana Care Health Services | 31 | 2022-04-22 | 2023-09-11 | |
| Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial Work of Breathing, ARDS | Unknown | Sanatorio de la Trinidad Mitre | 37 | 2019-04-01 | 2019-12-26 | |
| Work of Breathing and Kangaroo Mother Care Premature Infant, Work of Breathing | Completed | Christiana Care Health Services | 29 | 2018-11-01 | 2020-10-05 | |
| Comparison of Patient Work of Breathing and Tidal Volumes With High Flow Nasal Cannula Oxygen Therapy and NIV (Non-Invasive Ventilation) After Extubation in the ICU. High-Flow Nasal Oxygen / Non-invasive ventilation / Standard oxygen - ICU, Extubation | Not applicable | Unknown | Poitiers University Hospital | 25 | 2018-03-06 | 2019-07-31 |
| WOB and Paediatric Mechanical Ventilation Sprinting - Pediatric Respiratory Diseases, Ventilator Weaning | Not applicable | Completed | University Medical Center Groningen | 36 | 2017-11-29 | 2022-02-24 |
| Physiological Response in Lung Transplant Recipients Undergoing Neurally Adjusted Ventilatory Assist NAVA ventilation - Work of Breathing, Lung Transplant; Complications | Not applicable | Unknown | Policlinico Hospital | 20 | 2017-11-23 | 2017-12-08 |
| Gas Mask and Chronic Obstructive Pulmonary Disease (COPD): New Understanding on the Respiratory Index Impact? measurement of the work of breathing, Gas Mask - Work of Breathing | Not applicable | Completed | Laval University | 9 | 2016-06-01 | 2016-09-29 |
| The Gas Mask: the Effects on Respiration! measurement of the work of breathing, Gas mask - Work of Breathing | Not applicable | Completed | Laval University | 15 | 2015-06-01 | 2016-09-29 |
| Effort of Breathing Guided Ventilator Protocol Ventilator protocol, Esophageal Catheter - Ventilators, Mechanical, Work of Breathing | Not applicable | Completed | Children's Hospital Los Angeles | 32 | 2015-02-01 | 2024-10-30 |
Acidosis, Respiratory (2) · Hypoxia (2) · Respiratory Insufficiency (2) · Ventilator-Induced Lung Injury (2) · Dyspnea (1) · Lung Injury (1) · Premature Birth (1) · Pulmonary Disease, Chronic Obstructive (1) · Respiratory Aspiration (1)
Respiratory Tract Diseases (6) · Pathological Conditions, Signs and Symptoms (4) · Respiration Disorders (4) · Lung Diseases (3) · Signs and Symptoms (3) · Signs and Symptoms, Respiratory (3) · Acid-Base Imbalance (2) · Acidosis (2) · Metabolic Diseases (2) · Nutritional and Metabolic Diseases (2) · Pathologic Processes (2) · Respiratory Insufficiency (2) · Chronic Disease (1) · Disease Attributes (1) · Female Urogenital Diseases and Pregnancy Complications (1)
Respiratory Protective Devices (2) · EAP protocol (1) · Noninvasive Ventilation (1)
Indiana University (3) · Christiana Care Health Services (2) · Laval University (2) · Poitiers University Hospital (2) · Argentinian Intensive Care Society (1) · Children's Hospital Los Angeles (1) · Policlinico Hospital (1) · Sanatorio de la Trinidad Mitre (1) · University Medical Center Groningen (1) · University of Padova (1)
United States (6) · Argentina (2) · Canada (2) · France (2) · Italy (2) · Netherlands (1) · Switzerland (1)
Alberto Zanella, MD (1) · Antonio Pesenti, Prof (1) · Chiara Abbruzzese, MD (1) · Francois Lellouche, Doctorate (1) · Francois Lellouche, PhD (1) · Kelley Kovatis, MD (1) · Kelley Z Kovatis, MD (1) · Luigi Castagna, MD (1) · Nadia Corcione, MD (1) · Nicola Bottino, MD (1) · Robinder Khemani, MD (1) · Sebastian Fredes, RT (1)
PMID 32071135, PMID 30065082, PMID 33661521, PMID 33892948, PMID 35831900, PMID 36915106, PMID 40341100