28 completed, 11 recruiting, 6 unknown, 5 not yet recruiting. 38 Not applicable, 9 Phase 2, 7 Phase 3, 3 Phase 1, 1 Early Phase 1.
Follow Uncontrolled Hypertension: new trials by email Literature Review of Uncontrolled Hypertension trials Research Report on Uncontrolled Hypertension
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase IIIb Study to Investigate the Effect of Baxdrostat in Chinese Participants With Uncontrolled Hypertension. baxdrostat 2mg, Placebo 2mg - Uncontrolled Hypertension | Phase 3 | Recruiting | AstraZeneca | 286 | 2026-09-17 | 2026-10-15 |
| A Phase II Study of VB19055 in Uncontrolled or Resistant Hypertension VB19055 Dose A QD, VB19055 Dose B QD, VB19055 Dose C QD - Hypertension, Resistant Hypertension | Phase 2 | Not yet recruiting | Zhejiang Yangli Pharmaceutical Technology Co., Ltd. | 240 | 2026-09-01 | 2026-09-22 |
| Netrod-Pilot Study of Renal Denervation With NetrodTM Sixelectrode Radiofrequency RDN System Netrod™ six-electrode radiofrequency renal denervation system - Uncontrolled Hypertension | Not applicable | Not yet recruiting | Shanghai Golden Leaf MedTec Co. Ltd | 20 | 2026-04-01 | 2026-02-11 |
| Implementation of Effective Hypertension Management Approaches: OSF HealthCare Uncontrolled Hypertension | Enrolling by invitation | Colleen J Klein | 130 | 2026-03-06 | 2026-03-17 | |
| Renal Pelvic Denervation Pilot Trial RPD, Active hypertension medical therapy - Uncontrolled Hypertension | Not applicable | Recruiting | Verve Medical, Inc | 60 | 2026-01-30 | 2026-10-15 |
| A Food Effect Study of QLS1410 in Healthy Chinese Adults QLS1410 - Uncontrolled Hypertension | Phase 1 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 12 | 2026-01-23 | 2026-01-22 |
| A Phase II Clinical Trial of Efficacy and Safety of SAL0140 at Different Doses in Patients With Uncontrolled Hypertension SAL0140, Placebo - Uncontrolled Hypertension | Phase 2 | Recruiting | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 252 | 2025-12-09 | 2026-06-17 |
| A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension RTN-001, Matching placebo control - Uncontrolled Hypertension | Phase 2 | Recruiting | Retension Pharmaceuticals. Inc. | 280 | 2025-10-31 | 2026-10-02 |
| Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension iloperidone, Placebo - Hypertension, Uncontrolled Hypertension | Phase 2 | Recruiting | Vanda Pharmaceuticals | 240 | 2025-09-15 | 2026-02-27 |
| A Phase I Trial of QLS1410 in Healthy Chinese Adults and Participants With Mild Essential Hypertension QLS1410 (CYP11B2 inhibitor), placebo - Uncontrolled Hypertension | Phase 1 | Not yet recruiting | Qilu Pharmaceutical Co., Ltd. | 78 | 2025-09-01 | 2025-09-03 |
| EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System Netrod™ six-electrode radiofrequency renal denervation system, Sham Procedure - Uncontrolled Hypertension | Not applicable | Withdrawn | Shanghai Golden Leaf MedTec Co. Ltd | 2025-08-30 | 2025-07-31 | |
| Sequential Multiple Assignment Randomized Trial to Reduce Food Insecurity Resource information, Community Health Worker (CHW) assistance, Medically-tailored Meals (MTM) - Uncontrolled Hypertension | Not applicable | Recruiting | Wake Forest University Health Sciences | 224 | 2025-08-18 | 2026-05-06 |
| SAL0140 Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Study in a Healthy Chinese Population SAL0140, SAL0140 placebo - Uncontrolled Hypertension | Phase 1 | Recruiting | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 82 | 2025-06-09 | 2025-07-04 |
| Wearable Evaluation of Ambulatory Readings for Blood Pressure ABPMPro, Spacelabs Ambulatory Blood Pressure Monitoring, Aktiia Blood Pressure - Normal Blood Pressure, Controlled Hypertension | Not applicable | Recruiting | Stephen Juraschek | 100 | 2025-06-06 | 2026-06-11 |
| Community Health Workers Reduce Social Barriers That Affect the Health of Patients With High Blood Pressure and Diabetes. CHC-level cluster randomized control trial - Uncontrolled Diabetes, Uncontrolled Hypertension | Not applicable | Completed | Morehouse School of Medicine | 72726 | 2025-05-01 | 2026-07-09 |
| REGN5381 in Adult Participants With Uncontrolled Hypertension REGN5381, Placebo - Uncontrolled Hypertension | Phase 2 | Terminated | Regeneron Pharmaceuticals | 34 | 2025-04-16 | 2025-10-23 |
| SMART Study in Real World SyMapCath I™ catheter and SYMPIONEER S1™ Stimulator/Generator - Hypertension, Uncontrolled Hypertension | Not yet recruiting | SyMap Medical (Suzhou), Ltd. | 1000 | 2025-02-01 | 2025-02-17 | |
| Remote Hypertension Management for Black Patients RHYTHM (Remote Hypertension Tracking Help Management), Enhanced usual care (UC) - Uncontrolled Hypertension | Not applicable | Recruiting | Wake Forest University Health Sciences | 864 | 2024-12-13 | 2026-06-02 |
| Engaging Patients in Adherence Interventions Using Behavioral Science Primer postcard, Control recruitment letter, Behavioral theory-informed recruitment letter - Uncontrolled Hypertension | Not applicable | Enrolling by invitation | Columbia University | 584 | 2024-11-08 | 2025-12-09 |
| A Study to Evaluate the Efficacy and Safety in Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension SAL0120, Placebo - Uncontrolled Hypertension, Resistant Hypertension | Phase 3 | Completed | Shenzhen Salubris Pharmaceuticals Co., Ltd. | 256 | 2024-10-29 | 2026-08-27 |
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Hypertension (30) · Renal Insufficiency, Chronic (5) · Medication Adherence (4) · Cardiovascular Diseases (2) · Diabetes Mellitus (2) · Atrial Fibrillation (1) · Diabetic Nephropathies (1) · Health Behavior (1) · Heart Failure (1) · Heart Murmurs (1) · Hypertension Resistant to Conventional Therapy (1) · Kidney Failure, Chronic (1) · Patient Compliance (1) · Polycystic Kidney, Autosomal Dominant (1) · Pulmonary Disease, Chronic Obstructive (1)
Cardiovascular Diseases (29) · Vascular Diseases (29) · Female Urogenital Diseases (8) · Female Urogenital Diseases and Pregnancy Complications (8) · Kidney Diseases (8) · Male Urogenital Diseases (8) · Pathological Conditions, Signs and Symptoms (8) · Urogenital Diseases (8) · Urologic Diseases (8) · Pathologic Processes (7) · Chronic Disease (6) · Disease Attributes (6) · Renal Insufficiency (6) · Behavior (5) · Patient Acceptance of Health Care (5)
Telemedicine (2) · Blood Pressure Monitoring, Ambulatory (1) · Community Health Workers (1) · Denervation (1) · Drug Monitoring (1) · Ethnicity (1) · Gas Chromatography-Mass Spectrometry (1) · Insemination, Artificial, Heterologous (1) · Radionuclide Generators (1) · Standard of Care (1) · iloperidone (1)
AstraZeneca (5) · Medtronic Vascular (4) · Shenzhen Salubris Pharmaceuticals Co., Ltd. (3) · Vivek Reddy (3) · Abbott Medical Devices (2) · Qilu Pharmaceutical Co., Ltd. (2) · Shanghai Golden Leaf MedTec Co. Ltd (2) · University of Erlangen-Nürnberg Medical School (2) · University of Illinois at Urbana-Champaign (2) · Verve Medical, Inc (2) · Wake Forest University Health Sciences (2) · Akdeniz University (1) · Ankara University (1) · CVRx, Inc. (1) · Changi General Hospital (1)
United States (26) · China (9) · Germany (6) · Australia (5) · United Kingdom (5) · Czechia (4) · France (4) · Spain (4) · Turkey (Türkiye) (4) · Belgium (3) · Canada (3) · Italy (3) · Japan (3) · South Korea (3) · Argentina (2)
Vivek Reddy, MD (3) · George Bakris, MD (2) · Ajay K Gupta (1) · Andrew Sharp, Prof. (1) · Chongyuan Xu, Ph.D (1) · Christoph K Naber, MD (1) · Colleen Klein, PhD, APRN, FNP-BC (1) · Darrell J Gaskin, PhD (1) · Deepak L Bhatt, MD, MPH (1) · Deepak Palakshappa, MD, MSHP (1) · Dierk Scheinert, MD (1) · Felix Mahfoud, Prof. Dr. (1) · Fred Weaver, MD (1)
PMID 26558819, PMID 40850955, PMID 21093036, PMID 21358414, PMID 21518978, PMID 21884958, PMID 23248063, PMID 23780578, PMID 24678939, PMID 24858423, PMID 24898552, PMID 25400162, PMID 25835443, PMID 25912693, PMID 25982652, PMID 26873693, PMID 27788856, PMID 28158510, PMID 28611687, PMID 29162557, PMID 29627741, PMID 30964439, PMID 32526534, PMID 32749224, PMID 33319386, PMID 33377328, PMID 33566072, PMID 33781228, PMID 34275336, PMID 35080502, PMID 35612394, PMID 36130612, PMID 36254733, PMID 36322608, PMID 37490693, PMID 37500950, PMID 37651994, PMID 38530572, PMID 38606688, PMID 38713475, PMID 39138914, PMID 39356039, PMID 40198262, PMID 40616336, PMID 40802676, PMID 40813485, PMID 40888730, PMID 40913594, PMID 41660670, PMID 42028232
2023 (1), K01HL140288 (1), P30AG064198 (1), R01HL158622 (1), R01HL173064 (1), R34DK102166 (1), UH3HL130688 (1)