18 completed, 3 recruiting, 2 terminated, 2 unknown. 8 Phase 1, 7 Phase 4, 5 Phase 2, 5 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Completed 7, Unknown 1 |
| Phase 4 | 7 | Completed 5, Recruiting 1, Terminated 1 |
| Phase 2 | 5 | Completed 2, Recruiting 1, Terminated 1, Withdrawn 1 |
| Phase 3 | 5 | Completed 3, Recruiting 1, Unknown 1 |
Follow iloperidone: new trials by email Literature Review of iloperidone trials Research Report on iloperidone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Efficacy and Safety of Iloperidone for the Treatment of Participants With Uncontrolled Hypertension iloperidone, Placebo - Hypertension, Uncontrolled Hypertension | Phase 2 | Recruiting | Vanda Pharmaceuticals | 240 | 2025-09-15 | 2026-02-27 |
| Randomized Withdrawal Study in Patients With Schizophrenia iloperidone, placebo - Schizophrenia | Phase 3 | Recruiting | Vanda Pharmaceuticals | 400 | 2025-05-14 | 2026-01-12 |
| Pharmacokinetic Study of VHX-896 and Iloperidone Tablets Under Steady-State Conditions VHX-896 and iloperidone, Iloperidone and VHX-896 - Schizophrenia, Bipolar I Disorder | Phase 1 | Completed | Vanda Pharmaceuticals | 26 | 2024-07-11 | 2025-09-19 |
| Safety and Tolerability of Open-Labeled Iloperidone in Adolescents Iloperidone - Schizophrenia, Bipolar I Disorder | Phase 4 | Recruiting | Vanda Pharmaceuticals | 100 | 2023-05-24 | 2026-10-01 |
| A Study to Evaluate Iloperidone for the Treatment of Parkinson's Disease Psychosis Iloperidone - Parkinson Disease Psychosis | Phase 2 | Withdrawn | Vanda Pharmaceuticals | 2022-06-01 | 2024-03-21 | |
| Bioequivalence Study Between VHX-896 Tablets and Iloperidone Tablets in Healthy Volunteers VHX-896 and iloperidone, Iloperidone and VHX-896 - Healthy | Phase 1 | Completed | Vanda Pharmaceuticals | 25 | 2021-06-30 | 2022-07-11 |
| Evaluation of Efficacy and Safety of Iloperidone in the Acute Treatment of Manic or Mixed Episodes Associated With Bipolar I Disorder Iloperidone, Iloperidone Placebo - Bipolar I Disorder | Phase 3 | Completed | Vanda Pharmaceuticals | 417 | 2021-03-22 | 2024-04-18 |
| A Study to Evaluate Iloperidone Long-acting Injection (LAI) for the Treatment of Schizophrenia Iloperidone - Schizophrenia | Phase 1 | Completed | Vanda Pharmaceuticals | 42 | 2021-01-13 | 2023-06-29 |
| Evaluating a New Iloperidone Titration Scheme in Bipolar I Disorder or Schizophrenia Iloperidone - Bipolar I Disorder, Schizophrenia | Phase 1 | Completed | Vanda Pharmaceuticals | 12 | 2019-10-07 | 2020-04-13 |
| Human Bioequivalence Test (Fasting & Postprandial) of Iloperidone Tablets Iloperidone 1 MG, Placebo, fasting - Bioequivalence | Phase 1 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 36 | 2017-11-17 | 2018-02-05 |
| Family Intervention in Recent Onset Schizophrenia Treatment (FIRST) Caregiver psycho-education and skills training, Caregiver support available at the study site, Paliperidone palmitate - Schizophrenia | Completed | Janssen Scientific Affairs, LLC | 296 | 2015-07-24 | 2019-01-23 | |
| Risperidone-controlled,Multicentre Clinical Trial of Iloperidone in Patients With Schizophrenia Iloperidone, Risperidone - Schizophrenia | Phase 3 | Unknown | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 288 | 2013-11-01 | 2015-05-27 |
| Iloperidone for Symptoms of Arousal in Post Traumatic Stress Disorder (PTSD) Iloperidone, Placebo - Post Traumatic Stress Disorder | Phase 2 | Terminated | University of Colorado, Denver | 1 | 2013-07-01 | 2020-02-11 |
| An Observational Drug Utilization Study of Asenapine in the United Kingdom (P08308) Asenapine, Aripiprazole, Quetiapine - Bipolar Disorder | Completed | Organon and Co | 42 | 2013-04-01 | 2022-02-04 | |
| Assessment and Comparison of Metabolic Changes in Non-psychotic Adults Taking Iloperidone or Olanzapine or Placebo olanzapine, iloperidone, Placebo - Healthy | Phase 4 | Completed | New York State Psychiatric Institute | 31 | 2012-11-01 | 2017-03-20 |
| Efficacy and Safety Study of Iloperidone Virus Risperidone to Treat Schizophrenia iloperidone, Risperidone - Schizophrenia, Iloperidone | Phase 2 | Completed | Jiangsu Hansoh Pharmaceutical Co., Ltd. | 260 | 2012-06-01 | 2013-11-19 |
| Iloperidone in Mixed States of Bipolar Disorder iloperidone - Bipolar Disorder | Phase 4 | Completed | The University of Texas Health Science Center at San Antonio | 41 | 2012-04-01 | 2018-02-08 |
| Iloperidone Augmentation of SSRIs for Patients With Major Depressive Disorder With Residual Anger and Irritability Iloperidone, Placebo - Major Depressive Disorder | Phase 4 | Completed | Maurizio Fava, MD | 20 | 2012-04-01 | 2017-04-11 |
| Assessing the Effects of Fanapt® on Social Cognition in Schizophrenia Iloperidone - Schizophrenia, Schizoaffective Disorder | Phase 4 | Terminated | Northwestern University | 19 | 2012-04-01 | 2015-07-10 |
| Tolerability and Pharmacokinetics of Iloperidone in Adolescent Patients iloperidone (oral tablet) - Safety and Tolerability of Iloperidone | Phase 1 | Completed | Vanda Pharmaceuticals | 33 | 2011-10-01 | 2016-06-13 |
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Schizophrenia (14) · Bipolar Disorder (3) · Psychotic Disorders (3) · Depressive Disorder, Major (1) · Hypertension (1) · Mental Disorders (1) · Obesity (1) · Stress Disorders, Post-Traumatic (1) · Tooth, Impacted (1) · Weight Gain (1)
Vanda Pharmaceuticals (12) · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. (2) · Novartis Pharmaceuticals (2) · Janssen Scientific Affairs, LLC (1) · Jiangsu Hansoh Pharmaceutical Co., Ltd. (1) · Johns Hopkins University (1) · Maurizio Fava, MD (1) · New York State Psychiatric Institute (1) · Northwestern University (1) · Novartis (1) · Organon and Co (1) · The University of Texas Health Science Center at San Antonio (1) · University of Colorado, Denver (1)
United States (22) · China (3) · India (2) · Bulgaria (1) · Poland (1) · Ukraine (1)
Charles Bowden, MD (1) · Christoph Correll, MD (1) · Gloria Reeves, MD (1) · Jeffrey Lieberman, MD (1) · John Csernansky, MD (1) · Linmarie Sikich, MD (1) · Mark A. Riddle, MD (1) · Marla Hochfeld, MD, MD (1) · Maurizio Fava, MD (1) · Michael H Allen, M.D. (1)
PMID 19573479, PMID 26913173, PMID 27379654, PMID 29444618, PMID 35436231, PMID 38236020, PMID 7726714
R01MH080270 (1)