483 completed, 60 recruiting, 52 unknown, 44 terminated. 281 Not applicable, 129 Phase 2, 110 Phase 1, 66 Phase 3, 47 Phase 4.
Follow Type 1 Diabetes Mellitus: new trials by email Literature Review of Type 1 Diabetes Mellitus trials Research Report on Type 1 Diabetes Mellitus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. Recombinant Zoster Vaccine (Shingrix; RZV), Semaglutide (Ozempic®), Placebo (saline injection) - Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | Ministry of Health, Saudi Arabia | 240 | 2027-01-01 | 2026-05-29 |
| Sequential Immune Modulation and Antigen-Specific Tolerance Induction for Disease Modification in Recent-Onset Type 1 Diabetes Teplizumab, Intralymphatic Insulin Immunotherapy (ILIT) - Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus | Phase 1 | Not yet recruiting | Abdullah Kars | 60 | 2027-01-01 | 2026-05-27 |
| Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity Tirzepatide - Type 1 Diabetes Mellitus, Overweight and Obesity | Phase 2 | Not yet recruiting | Royal North Shore Hospital | 40 | 2026-12-01 | 2025-07-29 |
| A Phase 2 Two-Part Study of Oral PS1 in Healthy Volunteers and Adults With Newly Diagnosed Type 1 Diabetes PS1, Placebo - Type 1 Diabetes Mellitus | Phase 2 | Not yet recruiting | Pharmasaga Co. Ltd. | 36 | 2026-11-21 | 2026-10-22 |
| DiaBuddy: AI-Enabled Digital Self-Management for Youth With Type 1 Diabetes DiaBuddy: AI-Enabled Digital Self-Management Intervention, Usual Diabetes Care - Type 1 Diabetes Mellitus, Diabetes Self-Management Education | Not applicable | Not yet recruiting | Dr. Juwayria Omar | 140 | 2026-10-02 | 2026-10-06 |
| Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT) - Type 1 Diabetes Mellitus, Exercise Physiology | Not applicable | Not yet recruiting | Stanford University | 20 | 2026-10-01 | 2026-08-12 |
| VV-14299 and VV-14300 for the Treatment of Type 1 Diabetes VV-14300, VV-14299 - Type 1 Diabetes Mellitus | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 29 | 2026-10-01 | 2026-10-05 |
| VV-14300 for the Treatment of Type 1 Diabetes VV-14300 - Type 1 Diabetes Mellitus | Phase 1 / Phase 2 | Recruiting | Kriya Therapeutics, Inc. | 29 | 2026-10-01 | 2026-10-05 |
| Gastrointestinal Symptoms in Children With Type 1 Diabetes Type 1 Diabetes Mellitus | Not yet recruiting | Assiut University | 254 | 2026-09-26 | 2026-09-28 | |
| Exploring Skin Barrier Function, Recurrence of Diabetes Device-Related Contact Dermatitis, and Evaluation of Hydrocolloid and Silicone-Based Patches for Its Prevention in Children and Adolescents With Type 1 Diabetes hydrocolloid patch as patch used in the Sandwich method, Silicone-based patch as patch used in the Sandwitch method - Contact Dermatitis, Type 1 Diabetes Mellitus | Not applicable | Recruiting | Steno Diabetes Center Copenhagen | 30 | 2026-09-04 | 2026-08-25 |
| How Abnormal Function of Fat Tissue in Type 1 Diabetes Contributes to Fat in the Liver Imaging PET/MRI, Stable isotope infusions, meal test - Metabolic Dysfunction-Associated Steatotic Liver Disease, Non-Alcoholic Steato-Hepatitis (NASH) | Not applicable | Not yet recruiting | Université de Sherbrooke | 32 | 2026-09-01 | 2025-08-21 |
| Feasibility and Effectiveness of an AI-Powered Carbohydrate Counting Educational Platform to Support Parents of Children With Type 1 Diabetes AI-Powered Carbohydrate Counting Educational Platform - Type 1 Diabetes Mellitus | Not applicable | Not yet recruiting | Sultan Qaboos University | 80 | 2026-09-01 | 2026-06-30 |
| Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring. Sotagliflozin initiation - Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM) | Phase 2 | Not yet recruiting | HealthPartners Institute | 80 | 2026-09-01 | 2026-08-27 |
| Omnipod 5 Implementation in Belgian Paediatric Diabetes Care Tubeless Hybrid Closed-Loop Insulin Delivery System - Type 1 Diabetes Mellitus | Not yet recruiting | Queen Fabiola Children's University Hospital | 200 | 2026-09-01 | 2026-08-25 | |
| "Ultrasound-Enhanced Propolis Therapy for Healing Diabetic Foot Wounds" Sham ultrasound (placebo), Propolis gel (10%) - Diabetic Foot Ulcer t, Type 1 Diabetes Mellitus | Not applicable | Not yet recruiting | Sinai University | 80 | 2026-08-30 | 2026-08-04 |
| Oral Verapamil Among Newly Diagnosed Children and Adolescents With Type 1 Diabetes Verapamil oral, Placebo - Type 1 Diabetes Mellitus | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 70 | 2026-08-20 | 2026-09-04 |
| Cardiometabolic Effects of Non-Nutritive Sweeteners (NNS) in Type 1 Diabetes (T1D) Cherry Sports Drink - Non-Nutritive Sweetener, Type 1 Diabetes | Not applicable | Recruiting | Medical College of Wisconsin | 20 | 2026-08-05 | 2026-10-20 |
| Safety and Performance Evaluation of the SAVA Continuous Glucose Monitor for Effective Glucose Detection CGM Devices - Type 1 Diabetes Mellitus | Not applicable | Not yet recruiting | SAVA Technologies Ltd. | 20 | 2026-08-01 | 2026-07-07 |
| Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATG Antithymocyte Globulin (ATG), Teplizumab - Type 1 Diabetes Mellitus | Phase 2 | Recruiting | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 60 | 2026-07-29 | 2026-09-09 |
| Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes Tirzepatide 2.5mg weekly, Placebo injection (normal saline) - Type 1 Diabetes Mellitus | Phase 2 | Recruiting | Victor Chang Cardiac Research Institute | 44 | 2026-07-07 | 2026-09-16 |
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Diabetes Mellitus, Type 1 (721) · Diabetes Mellitus (85) · Hypoglycemia (50) · Diabetes Mellitus, Type 2 (45) · Insulin Resistance (33) · Motor Activity (29) · Autoimmune Diseases (14) · Hyperglycemia (13) · Diabetic Nephropathies (7) · Metabolic Diseases (7) · Overweight (6) · Diabetes Complications (5) · Diabetic Ketoacidosis (5) · Endocrine System Diseases (5) · Glucose Metabolism Disorders (5)
Nutritional and Metabolic Diseases (721) · Immune System Diseases (718) · Endocrine System Diseases (716) · Glucose Metabolism Disorders (716) · Metabolic Diseases (714) · Autoimmune Diseases (707) · Diabetes Mellitus (636) · Behavior (39) · Hyperinsulinism (33) · Pathological Conditions, Signs and Symptoms (29) · Urogenital Diseases (25) · Female Urogenital Diseases and Pregnancy Complications (23) · Male Urogenital Diseases (19) · Female Urogenital Diseases (17) · Pathologic Processes (16)
Insulin Lispro (41) · Insulin (30) · Insulin Glargine (30) · Insulin Aspart (27) · Continuous Glucose Monitoring (11) · Islets of Langerhans Transplantation (11) · insulin degludec (11) · Pancreas, Artificial (9) · pramlintide (9) · teplizumab (9) · Glucagon (8) · dapagliflozin (8) · Antilymphocyte Serum (7) · insulin glulisine (7) · (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triol (6)
Sanofi (28) · University of Virginia (27) · Eli Lilly and Company (14) · Medtronic MiniMed, Inc. (14) · Sansum Diabetes Research Institute (12) · University of Colorado, Denver (12) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (11) · National Institute of Allergy and Infectious Diseases (NIAID) (10) · Adocia (9) · AstraZeneca (9) · Mannkind Corporation (8) · Nemours Children's Clinic (8) · Stanford University (8) · Institut de Recherches Cliniques de Montreal (7) · University of Ljubljana, Faculty of Medicine (7)
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Bruce Buckingham, MD (9) · Sue Brown, MD (9) · Eyal Dassau, PhD (7) · Jordan E Pinsker, MD (6) · Rodolfo Alejandro, MD (6) · Grit Andersen, MD (5) · Remi Rabasa-Lhoret (5) · Steven J Russell, MD, PhD (5) · Howard Zisser, MD (4) · Rubina A Heptulla, MD (4) · Bernhard J. Hering, M.D. (3) · Boris Kovatchev, PhD (3)
PMID 39735417, PMID 42459945, PMID 19005394, PMID 23801798, PMID 33481552, PMID 35403243, PMID 19064853, PMID 19636033, PMID 20150283, PMID 20448066, PMID 20536518, PMID 21030684, PMID 21500267, PMID 21947298, PMID 22077236, PMID 22688340, PMID 22729476, PMID 22990096, PMID 23027646, PMID 23212717, PMID 23265339, PMID 23438305, PMID 23474588, PMID 23520132, PMID 23761102, PMID 24170751, PMID 24264395, PMID 24309189, PMID 24459159, PMID 24722493, PMID 24836354, PMID 24934506, PMID 25043685, PMID 25204977, PMID 25218922, PMID 25562265, PMID 25584994, PMID 25923552, PMID 25980755, PMID 25984873, PMID 26068866, PMID 26192006, PMID 26341632, PMID 26559501, PMID 26584339, PMID 26641212, PMID 26718501, PMID 26861924, PMID 26864236, PMID 26895792
2015 (5), 2014 (3), 2017 (3), 2018 (3), R01DK085623 (3), U01DK061055 (3), UC4DK097835 (3), 2019 (2), UC4DK108483 (2), 1DP3DK094292-01 (1), 1DP3DK101055 (1), 1DP3DK113235-01 (1), 1UC4DK095300-01 (1), 1UC4DK100238-01 (1), 1UC4DK106955-01 (1)