24 completed, 4 unknown, 2 withdrawn, 1 not yet recruiting. 29 Not applicable, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 29 | Completed 22, Unknown 4, Withdrawn 2, Not yet recruiting 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Automated Insulin Delivery Versus Daily Injections for Hospital Diabetes Care automated insulin delivery system, GlucoTab, Control-arm - Diabetes Mellitus Type 2, Infection | Not applicable | Not yet recruiting | Steno Diabetes Center Copenhagen | 92 | 2026-07-01 | 2026-06-12 |
| Dual-hormone Artificial Pancreas Versus Single-hormone Under Exercise and a Meal Challenge Automated insulin delivery system algorithm with a dual-hormone configuration (insulin and glucagon) for glucose control, Automated insulin delivery system with a single-hormone configuration (insulin) with rescue carbohydrate recommendations for glucose control - Type 1 Diabetes | Not applicable | Completed | Universitat Politècnica de València | 15 | 2024-05-15 | 2025-12-18 |
| Safety and Effectiveness of Automated Insulin Delivery (AID) Systems in Physically Active Adults With Type 1 Diabetes Automated insulin delivery system - Type 1 Diabetes | Completed | Institut de Recherches Cliniques de Montreal | 76 | 2022-12-01 | 2026-03-05 | |
| Portable Artificial Pancreas Applied for Youth and Adolescents Bi-hormonal closed-loop control, Open-loop control - Diabetes Mellitus, Type 1 | Not applicable | Completed | Inreda Diabetic B.V. | 20 | 2022-10-28 | 2023-08-14 |
| A Fully-closed Loop, Pramlintide and Insulin, Artificial Pancreas Clinical Trial for Adults With Type 1 Diabetes Fiasp, Artificial Pancreas, Pramlintide - Type 1 Diabetes | Not applicable | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 12 | 2022-02-21 | 2023-10-25 |
| Co-administration of Pramlintide and Insulin Via an Automated Dual-hormone Artificial Pancreas System in Adults With Type 1 Diabetes Rapid-Acting Insulin, Placebo, Pramlintide Acetate - Diabetes Mellitus, Type 1, Type 1 Diabetes | Not applicable | Unknown | McGill University | 26 | 2021-11-12 | 2023-03-15 |
| Artificial Pancreas With Carbohydrate Suggestion for Patients With Type 1 Diabetes Prone to Hypoglycemia Automated Insulin Delivery System (SAFE-AP) - Type 1 Diabetes Mellitus Prone to Hypoglycemia | Not applicable | Completed | Hospital Clinic of Barcelona | 12 | 2021-10-22 | 2022-11-29 |
| Evaluation of Satisfaction Regarding Home Healthcare Provider (HHP) Management of Type 1 Diabetic Patients Using a Closed-loop Automatic Insulin Delivery System any closed-loop automatic insulin delivery system (or artificial pancreas) European Conformity (CE)-marking - Diabetes type1 | Not applicable | Completed | Air Liquide Santé International | 35 | 2021-05-10 | 2024-10-15 |
| Use of Closed Loop Insulin Delivery for Glucose Control in Patients With Insulin Dependent Diabetes Mellitus After Kidney Transplantation Artificial Pancreas, Multiple Daily Injections - Type 1 Diabetes, Insulin-requiring Type 2 Diabetes Mellitus | Not applicable | Withdrawn | University of Virginia | 2021-04-01 | 2021-11-10 | |
| Artificial Pancreas - Adolescent Physiology & Psychology Longitudinal Evaluation Artificial Pancreas (AP) - Type 1 Diabetes | Not applicable | Completed | University of Virginia | 42 | 2020-11-19 | 2025-12-10 |
| Efficacy of Closed-loop Insulin Therapy in Adults Prone to Hypoglycemia Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions, Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring - Type 1 Diabetes Mellitus With Hypoglycemia | Not applicable | Unknown | University Hospital, Montpellier | 72 | 2020-05-13 | 2021-12-15 |
| Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas Fiasp, Pramlintide Acetate, Placebo - Type 1 Diabetes, Type 1 Diabetes Mellitus | Not applicable | Completed | McGill University | 36 | 2020-02-14 | 2022-10-10 |
| Safety of Artificial Pancreas Therapy in Preschoolers, Age 2-6 Tandem t:slim X2 with Control-IQ Technology + Dexcom G6 - Type 1 Diabetes | Not applicable | Completed | University of Virginia | 12 | 2019-09-26 | 2023-03-22 |
| Effect of SGLT2i in Conjunction With the Artificial Pancreas on Improving the Glycemia in T1DM in the Outpatient Setting empagliflozin, artificial pancreas - Type1 Diabetes Mellitus | Phase 3 | Completed | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 28 | 2019-08-01 | 2022-06-07 |
| Algorithm to Control Postprandial, Post Exercise and Night Glucose Excursions in a Portable Closed Loop Format, Insulin pump therapy (with or without glucose sensor), Artificial pancreas (Inreda Diabetic) - Diabetes Mellitus, Type 1 | Not applicable | Completed | J.H. DeVries | 36 | 2019-03-10 | 2019-10-22 |
| Efficacy of Closed-loop Insulin Therapy in Prepubertal Child in Free-life Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions - Type 1 Diabetes Mellitus in Prepubertal Children | Not applicable | Unknown | University Hospital, Montpellier | 122 | 2018-11-05 | 2021-12-16 |
| Efficacy of Closed-Loop Strategy With and Without a Learning Component in Children and Adolescents With Type 1 Diabetes at a Diabetes Camp Artificial Pancreas - Diabetes, Type 1 Diabetes Mellitus | Not applicable | Completed | McGill University | 45 | 2018-07-02 | 2018-11-29 |
| Artificial Pancreas and Remote Monitoring During a T1DM Youth Ski Camp Tandem t:slim X2 with Control-IQ Technology + Dexcom G6, Dexcom CGM G5, Continuous Subcutaneous Insulin Infusion - Type 1 Diabetes Mellitus | Not applicable | Completed | University of Virginia | 48 | 2017-12-18 | 2024-10-01 |
| The International Diabetes Closed Loop (iDCL) Trial: Protocol 1 Artificial Pancreas, Sensor Augmented Therapy - Type1 Diabetes Mellitus | Not applicable | Completed | University of Virginia | 127 | 2017-10-27 | 2022-12-05 |
| Feasibility Evaluation of an Artificial Pancreas With Glucose Prediction Trust Index Artificial Pancreas Device - Type 1 Diabetes Mellitus | Not applicable | Completed | Sansum Diabetes Research Institute | 15 | 2017-03-20 | 2018-07-12 |
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Diabetes Mellitus, Type 1 (26) · Diabetes Mellitus (3) · Diabetes Mellitus, Type 2 (2) · Hyperglycemia (2) · Hypoglycemia (2) · Insulin Resistance (2) · Cardiovascular Diseases (1) · Infections (1) · Kidney Failure, Chronic (1) · Pancreatic Diseases (1) · Pancreatic Neoplasms (1)
University of Virginia (6) · McGill University (3) · University Hospital, Montpellier (3) · J.H. DeVries (2) · Kochi University (2) · Sansum Diabetes Research Institute (2) · Air Liquide Santé International (1) · Boston University Charles River Campus (1) · Hospital Clinic of Barcelona (1) · Imperial College London (1) · Inreda Diabetic B.V. (1) · Institut de Recherches Cliniques de Montreal (1) · Insulet Corporation (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Samuel Lunenfeld Research Institute, Mount Sinai Hospital (1)
United States (10) · Canada (6) · France (5) · Netherlands (4) · Italy (2) · Japan (2) · Spain (2) · Austria (1) · Denmark (1) · United Kingdom (1)
Boris P. Kovatchev, PhD (2) · Marc Breton, PhD (2) · Stacey M. Anderson, MD (2) · Alejandro Leguna, PhD (1) · Arianne Bon, MD, PhD (1) · Bruce A. Buckingham (1) · Bruce Buckingham, MD (1) · Bruce Perkins, MD (1) · Daniela Bruttomesso, MD (1) · Desmond Johnston, MBChB,PhD,FRCP (1) · Eyal Dassau, PhD (1) · F. Javier Ampudia-Blasco, MD PhD (1)
PMID 22923666, PMID 23275350, PMID 24623024, PMID 24801544, PMID 25901023, PMID 27208335, PMID 29958023, PMID 31099946, PMID 31937608, PMID 33226837, PMID 33397767, PMID 36927054, PMID 37729080, PMID 38906614
UC4DK108483 (3), R01DK085633 (1), R01DK124886 (1)