12 completed, 3 terminated, 2 recruiting, 2 unknown. 19 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 19 | Completed 12, Terminated 3, Recruiting 2, Unknown 2 |
| Phase 2 | 3 | Completed 3 |
Follow Trigeminal Autonomic Cephalalgias: new trials by email Literature Review of Trigeminal Autonomic Cephalalgias trials Research Report on Trigeminal Autonomic Cephalalgias
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Civamide Nasal Solution for Cluster Headache Civamide nasal solution 0.01% - Episodic Cluster Headache | Phase 3 | Unknown | Winston Laboratories | 180 | 2023-11-01 | 2021-04-23 |
| Repeated GON Injections in CCH Methylprednisolone, Saline solution - Cluster Headache | Phase 3 | Recruiting | Leiden University Medical Center | 50 | 2022-11-07 | 2025-11-24 |
| A 1-year Trial to Inform About Long-term Exposure to Eptinezumab in Participants With Chronic Cluster Headache (cCH) Eptinezumab - Chronic Cluster Headache | Phase 3 | Completed | H. Lundbeck A/S | 131 | 2021-09-17 | 2024-08-06 |
| Eptinezumab in Participants With Episodic Cluster Headache Eptinezumab, Placebo - Cluster Headache, Episodic | Phase 3 | Completed | H. Lundbeck A/S | 231 | 2020-12-23 | 2024-08-09 |
| Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache Botulinum toxin type A, placebo - Cluster Headache | Phase 3 | Recruiting | Norwegian University of Science and Technology | 112 | 2019-11-01 | 2024-11-19 |
| Double-Blind Comparison of the Efficacy and Safety of C213 to Placebo for the Acute Treatment of Cluster Headaches C213 Microneedle System, Placebo - Cluster Headache | Phase 2 / Phase 3 | Completed | Zosano Pharma Corporation | 42 | 2019-10-03 | 2022-06-14 |
| A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache Fremanezumab - Cluster Headache | Phase 3 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 275 | 2017-04-27 | 2021-11-09 |
| A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH) Fremanezumab, Placebo - Episodic Cluster Headache | Phase 3 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 169 | 2017-01-19 | 2021-11-09 |
| A Study Comparing the Efficacy and Safety of Fremanezumab (TEV-48125) for the Prevention of Chronic Cluster Headache (CCH) Fremanezumab, Placebo - Chronic Cluster Headache | Phase 3 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 259 | 2017-01-17 | 2021-11-09 |
| A Study of LY2951742 (Galcanezumab) in Participants With Cluster Headache Galcanezumab - Episodic Cluster Headache, Chronic Cluster Headache | Phase 3 | Completed | Eli Lilly and Company | 165 | 2016-07-13 | 2022-02-10 |
| Sodium Oxybate in Patients With Episodic and Chronic Cluster Headache Sodium Oxybate, Placebo - Cluster Headache | Phase 3 | Unknown | Ramin Khatami | 60 | 2015-12-01 | 2015-12-22 |
| A Study of Galcanezumab in Participants With Chronic Cluster Headache Galcanezumab 300 mg, Placebo - Chronic Cluster Headache | Phase 3 | Completed | Eli Lilly and Company | 240 | 2015-06-18 | 2020-08-25 |
| A Study Of Galcanezumab In Participants With Episodic Cluster Headache Galcanezumab, Placebo - Episodic Cluster Headache | Phase 3 | Completed | Eli Lilly and Company | 109 | 2015-05-22 | 2019-09-09 |
| Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache tDCS - Chronic Cluster Headache | Phase 2 / Phase 3 | Completed | University of Liege | 32 | 2014-09-01 | 2016-12-07 |
| Occipital Nerve Stimulation in Medically Intractable Chronic Cluster Headache occipital nerve stimulation - Chronic Cluster Headache | Phase 3 | Completed | Leiden University Medical Center | 130 | 2010-10-01 | 2020-02-28 |
| Cluster Headache Cortivazol Injection (CHCI) ALTIM, cortivazol injections, PROAMP, subcutaneous serum physiological saline, Verapamil - Cluster Headache | Phase 2 / Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 43 | 2008-12-01 | 2012-11-27 |
| Study Of Sumatriptan Succinate Injection Kit In Patients With Migraine or Cluster Headache In Japan Sumatriptan Succinate - Migraine Disorders | Phase 3 | Completed | GlaxoSmithKline | 75 | 2006-06-20 | 2018-09-04 |
| Intranasal Civamide for Episodic Cluster Headache Civamide (Zucapsaicin), Sodium Chloride - Episodic Cluster Headache | Phase 3 | Completed | Winston Laboratories | 2 | 2003-08-01 | 2011-06-10 |
| A Phase III Study of Civamide Nasal Solution (Zucapsaicin) for the Treatment of Episodic Cluster Headache Civamide (Zucapsaicin) - Episodic Cluster Headache | Phase 3 | Completed | Winston Laboratories | 60 | 2002-01-01 | 2011-06-10 |
Cluster Headache (19) · Headache (4) · Brain Diseases (1) · Central Nervous System Diseases (1) · Headache Disorders (1) · Headache Disorders, Primary (1) · Migraine Disorders (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Pain (1)
Brain Diseases (18) · Central Nervous System Diseases (18) · Headache Disorders (18) · Headache Disorders, Primary (18) · Nervous System Diseases (18) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Neurologic Manifestations (3) · Pain (3)
fremanezumab (3) · galcanezumab (3) · Sodium Chloride (2) · eptinezumab (2) · zucapsaicin (2) · Botulinum Toxins, Type A (1) · Methylprednisolone (1) · Saline Solution (1) · Sodium Oxybate (1) · Sumatriptan (1) · Transcranial Direct Current Stimulation (1) · Verapamil (1)
Eli Lilly and Company (3) · Teva Branded Pharmaceutical Products R&D, Inc. (3) · Winston Laboratories (3) · H. Lundbeck A/S (2) · Leiden University Medical Center (2) · Assistance Publique - Hôpitaux de Paris (1) · GlaxoSmithKline (1) · Norwegian University of Science and Technology (1) · Ramin Khatami (1) · University of Liege (1) · Zosano Pharma Corporation (1)
United States (11) · Germany (10) · Netherlands (10) · Italy (9) · Spain (9) · United Kingdom (9) · Finland (8) · Belgium (6) · Canada (6) · France (6) · Denmark (5) · Greece (4) · Sweden (4) · Australia (3) · Israel (3)
Delphine Magis, MD (1) · Don Kellerman, PharmD (1) · Michel Ferrari, MD PhD (1) · Ramin Khatami, MD (1) · Scott B Phillips, M.D. (1) · Scott B Phillips, MD (1) · Scott B. Phillips, M.D. (1)
PMID 38162453, PMID 21903477, PMID 31291515, PMID 32050782, PMID 34146510, PMID 34267550, PMID 35633025, PMID 36739508, PMID 40252664, PMID 40388178
2016 (3), 2015 (2), 2014 (1), 2018 (1)