3 not yet recruiting, 3 recruiting, 2 active not recruiting, 1 withdrawn. 5 Phase 2, 3 Not applicable, 1 Phase 1.
Follow Treatment-Resistant Major Depressive Disorder: new trials by email Literature Review of Treatment-Resistant Major Depressive Disorder trials Research Report on Treatment-Resistant Major Depressive Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Precision Closed-loop Brain-Computer Interface Neuromodulation for Treatment-Resistant Depression Closed-loop Deep Brain Stimulation (DBS), Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) - Treatment-Resistant Major Depressive Disorder, Major Depressive Disorder | Not applicable | Not yet recruiting | Shanghai Mental Health Center | 70 | 2026-08-01 | 2026-08-28 |
| Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) Ketamine Hydrochloride, Midazolam Hydrochloride, Dialectical Behavioral Therapy (DBT) - Borderline Personality Disorder (BPD), Treatment-Resistant Major Depressive Disorder | Phase 2 | Recruiting | Joshua Rosenblat | 120 | 2026-07-16 | 2026-07-29 |
| Triple-Blind Randomized Clinical Trial of Tocilizumab vs Placebo: Potential Use of an IL-6 Antagonist as an Adjuvant to Standard Treatment for Treatment-Resistant Major Depression in the Brazilian Public Health System (SUS) Tocilizumab, Normal Saline (0.9% NaCl) - Treatment-Resistant Major Depressive Disorder | Phase 2 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 32 | 2026-07-01 | 2026-05-15 |
| Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy Psilocybin 25mg, Music-centered psilocybin-assisted therapy, Mindfulness-centered psilocybin-assisted therapy - Treatment-Resistant Major Depressive Disorder | Phase 2 | Not yet recruiting | Kyle Greenway | 16 | 2026-05-01 | 2026-04-22 |
| Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression Virtual-Reality-based mindfulness intervention, Esketamine Treatment as Usual (ESK) - Depression - Major Depressive Disorder, Depression Disorder | Not applicable | Recruiting | Hospital Universitari Vall d'Hebron Research Institute | 30 | 2025-09-18 | 2026-02-27 |
| Personalized Ultrasonic Brain Stimulation for Depression (R61) LTFUS to SCC, LTFUS to ALIC - Major Depressive Episode, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Active not recruiting | Brian Mickey | 30 | 2025-03-10 | 2026-09-08 |
| Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study Major Depressive Disorder (MDD), Major Depressive Episode | Recruiting | Unity Health Toronto | 200 | 2024-12-16 | 2024-12-13 | |
| Avatar Therapy in Virtual Reality for Treatment-Resistant Major Depressive Disorder: A Pilot Study Avatar Therapy - Treatment-Resistant Major Depressive Disorder | Not applicable | Active not recruiting | Ciusss de L'Est de l'Île de Montréal | 15 | 2024-08-01 | 2025-08-08 |
| The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD Psilocybin - Treatment-Resistant Major Depressive Disorder | Phase 2 | Withdrawn | Massachusetts General Hospital | 2022-09-15 | 2024-01-24 |
Depressive Disorder, Treatment-Resistant (5) · Depressive Disorder, Major (4) · Bipolar Disorder (1) · Borderline Personality Disorder (1) · Patient Preference (1) · Rumination Syndrome (1) · Suicidal Ideation (1)
Depressive Disorder (6) · Mental Disorders (6) · Mood Disorders (6) · Behavior (2) · Behavioral Symptoms (1) · Bipolar and Related Disorders (1) · Digestive System Diseases (1) · Feeding and Eating Disorders (1) · Gastrointestinal Diseases (1) · Health Behavior (1) · Patient Satisfaction (1) · Personality Disorders (1) · Self-Injurious Behavior (1) · Suicide (1) · Treatment Adherence and Compliance (1)
Psilocybin (2) · Ketamine (1) · Midazolam (1) · Saline Solution (1) · tocilizumab (1)
Brian Mickey (1) · Ciusss de L'Est de l'Île de Montréal (1) · Hospital Universitari Vall d'Hebron Research Institute (1) · Hospital de Clinicas de Porto Alegre (1) · Joshua Rosenblat (1) · Kyle Greenway (1) · Massachusetts General Hospital (1) · Shanghai Mental Health Center (1) · Unity Health Toronto (1)
Canada (4) · United States (2) · Brazil (1) · Spain (1)
Alexandre Dumais, Md, PhD (1) · Brian J Mickey (1) · Dr. Srihar Krishnan, Ph.D., Peng., F.C.A.E. (1) · Dr. Wendy Lou, Ph.D. (1) · Joshua D. Rosenblat, MD, MSc (1) · Kyle T Greenway, MD (1) · Neusa Sica da Rocha, PhD (1) · Sharmin Ghaznavi, MD, PhD (1)
R61MH134943 (1)