8 recruiting, 5 unknown, 4 completed, 1 suspended. 19 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Recruiting 8, Unknown 5, Completed 4, Suspended 1, Terminated 1 |
Follow Treatment-Resistant Depression: new trials by email Literature Review of Treatment-Resistant Depression trials Research Report on Treatment-Resistant Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stereotactic Radiotherapy Treatment for Treatment-Resistant Depression ZAP-X - Treatment-Resistant Depression, Depressive Disorder | Not applicable | Completed | Capital Medical University | 9 | 2026-01-26 | 2026-08-10 |
| Ultrasound Neuromodulation of Circuits and Negative Valence Systems in Treatment-Resistant Depression Low-intensity focused ultrasound - Treatment-Resistant Depression | Not applicable | Recruiting | Laureate Institute for Brain Research, Inc. | 140 | 2025-09-30 | 2026-03-02 |
| Focused Ultrasound Neuromodulation in Patients With Treatment-Resistant Depression Next Generation Dome Helmet (NGDH) - Treatment-Resistant Depression, Treatment-resistant Depression (TRD) | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 20 | 2025-07-11 | 2025-08-11 |
| Magnetic Resonance-Guided Focused Ultrasound Bilateral Capsulotomy for the Treatment of Refractory Bipolar Depression ExAblate Neuro 4000 - Treatment-Resistant Depression, Bipolar Depression | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 10 | 2025-06-25 | 2025-08-06 |
| Physical Activity Program for TRD PA program - MoveU.HappyU - Treatment-resistant Depression, Major Depressive Disorder | Not applicable | Recruiting | Unity Health Toronto | 30 | 2024-09-19 | 2025-04-30 |
| Transcranial Alternating Current Stimulation for Treatment-Resistant Depression transcranial alternating current stimulation (tACS), Sham tACS - Treatment-Resistant Depression | Not applicable | Unknown | Xuanwu Hospital, Beijing | 200 | 2024-02-01 | 2024-01-31 |
| Olfactory and Brain Stimulations in Treatment-resistant Depression Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) combined with pleasant odors delivered during the iTBS procol., Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) delivered alone. - Treatment-resistant Depression | Not applicable | Recruiting | Hôpital le Vinatier | 80 | 2024-01-27 | 2025-07-24 |
| pBFS Guided High-dose rTMS Therapy for Treatment-Resistant Depression Active rTMS with short inter-session interval, Sham rTMS with short inter-session interval, Active rTMS with long inter-session interval - Treatment-Resistant Depression | Not applicable | Suspended | Changping Laboratory | 60 | 2023-06-19 | 2026-05-06 |
| Adjuvant Accelerated piTBS for Reducing Suicidal Ideation in TRD Patients piTBS being delivered using the Magstim Rapid2 stimulator - Major Depressive Disorder, Treatment-Resistant Depression | Not applicable | Completed | Tri-Service General Hospital (TSGH) | 100 | 2023-03-29 | 2025-05-13 |
| Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology non-invasive transcranial deep brain stimulation, Sham stimulation, Motor cortex stimulation - Treatment-Resistant Depression | Not applicable | Unknown | First Affiliated Hospital of Zhejiang University | 400 | 2023-01-01 | 2023-03-21 |
| The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression active iTBS, sham rTMS - Treatment-resistant Depression | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 60 | 2023-01-01 | 2023-01-13 |
| Cortical Inhibition as a Biomarker of Response in a Comparison of Bilateral Versus Unilateral Accelerated Theta Burst Stimulation for Suicidal Ideation in Treatment-Resistant Depression -COMBAT-SI Accelerated Theta Burst Stimulation - Suicidal Ideation, Treatment-resistant Depression | Not applicable | Recruiting | University of California, San Diego | 76 | 2022-09-02 | 2025-11-05 |
| Dorsomedial Prefrontal Neuromodulation in Treatment-resistant Depression Prolonged intermittent theta burst stimulation (piTBS), 20Hz rTMS, sham control - Treatment-resistant Depression, Major Depressive Disorder | Not applicable | Unknown | Taipei Veterans General Hospital, Taiwan | 75 | 2022-06-07 | 2022-08-17 |
| A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients inpatient CBASP individual therapy, inpatient CBASP group therapy, inpatient CBASP nurse contact - Persistent Depressive Disorder, Treatment-resistant Depression | Not applicable | Recruiting | University of Greifswald | 396 | 2021-12-01 | 2026-05-26 |
| Cost-utility Analysis of Maintenance rTMS for Treatment-resistant Depression Systematic maintenance rTMS, rTMS course in case of relapse, sham rTMS - Treatment-resistant Depression | Not applicable | Unknown | Nantes University Hospital | 119 | 2018-11-05 | 2022-09-16 |
| Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression Vercise GEVIA deep brain stimulation (DBS) system - Treatment-resistant Depression | Not applicable | Completed | University Hospital Freiburg | 46 | 2018-09-03 | 2026-04-28 |
| SSM vs HEP in Late-Life Depression Sahaj Samadhi Meditation (SSM), Health Enhancement Program (HEP) - Late-life Depression, Treatment-resistant Depression | Not applicable | Terminated | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 95 | 2018-08-20 | 2022-04-20 |
| Psychosocial Characteristics and Non-pharmacological Intervention of Patients With Treatment-resistant Depression Nurse-led cognitive-behavioral-based group intervention - Treatment-resistant Depression | Not applicable | Completed | National Taiwan University Hospital | 46 | 2018-01-09 | 2021-05-10 |
| Focal Electrically Administered Seizure Therapy for the Treatment of Depression Focal Electrically Administered Seizure Therapy - Treatment-Resistant Depression | Not applicable | Unknown | Ziad Nahas | 30 | 2013-09-01 | 2016-04-06 |
Depressive Disorder, Treatment-Resistant (19) · Depression (6) · Depressive Disorder, Major (4) · Depressive Disorder (2) · Anhedonia (1) · Bipolar Disorder (1) · Motor Activity (1) · Suicidal Ideation (1)
Mental Disorders (19) · Mood Disorders (19) · Depressive Disorder (17) · Behavior (8) · Behavioral Symptoms (7) · Bipolar and Related Disorders (1) · Nervous System Diseases (1) · Neurobehavioral Manifestations (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Self-Injurious Behavior (1) · Signs and Symptoms (1) · Suicide (1)
Antidepressive Agents (1) · Deep Brain Stimulation (1) · Drug Delivery Systems (1) · Transcranial Direct Current Stimulation (1)
First Affiliated Hospital of Zhejiang University (2) · Sunnybrook Health Sciences Centre (2) · Capital Medical University (1) · Changping Laboratory (1) · Hôpital le Vinatier (1) · Laureate Institute for Brain Research, Inc. (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Nantes University Hospital (1) · National Taiwan University Hospital (1) · Taipei Veterans General Hospital, Taiwan (1) · Tri-Service General Hospital (TSGH) (1) · Unity Health Toronto (1) · University Hospital Freiburg (1) · University of California, San Diego (1) · University of Greifswald (1)
Canada (4) · China (4) · France (3) · Taiwan (3) · Germany (2) · United States (2) · Lebanon (1)
Chia-yi Wu, PhD (1) · Chih-Ming Cheng, M.D. (1) · Eva-Lotta Brakemeier, Prof. Dr. (1) · Gang Wang, Medical Doctor (1) · Hesheng Liu, Ph.D. (1) · Hongxing Wang, MD & PhD (1) · Hsin-An Chang, MD (1) · Longsheng Pan, Medical Doctor (1) · Manli Huang, Professor (1) · Samuel Bulteau, MD (1) · Ziad Nahas, MD, MSCR (1)
PMID 31651355, PMID 32248820, PMID 39744036, PMID 40892783, PMID 41922057