16 completed, 2 recruiting. 9 Not applicable, 6 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 9 | Completed 7, Recruiting 2 |
| Phase 3 | 6 | Completed 6 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Tourette's Disorder: new trials by email Literature Review of Tourette's Disorder trials Research Report on Tourette's Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Remote Delivery of a Mindfulness-based Intervention for Tics mindfulness-based intervention for tics (MBIT), psychoeducation with relaxation and supportive therapy (PRST) - Tourette Syndrome, Tourette's Disorder | Not applicable | Recruiting | Johns Hopkins University | 150 | 2024-05-23 | 2026-05-11 |
| Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder Forehead Temperature-Regulating Therapy - Tourette's Disorder, Insomnia | Not applicable | Recruiting | University of California, Los Angeles | 25 | 2023-04-27 | 2025-03-17 |
| Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder Exposure and response prevention (ERP), Education on tics - Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder | Not applicable | Completed | Karolinska Institutet | 221 | 2019-04-26 | 2022-08-23 |
| Investigating Circadian Rhythms in Youth With Persistent Tic Disorders Wearable short wavelength light therapy - Tourette's Disorder | Not applicable | Completed | University of California, Los Angeles | 35 | 2018-01-18 | 2023-12-12 |
| Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Internet-delivered habit reversal training, Internet-delivered exposure and response prevention - Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder | Not applicable | Completed | Karolinska Institutet | 23 | 2016-08-01 | 2018-03-06 |
| TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) TicHelper, Internet Based Resources - Tourette's Disorder, Persistent (Chronic) Motor or Vocal Tic Disorder | Not applicable | Completed | University of Utah | 55 | 2015-08-01 | 2017-12-18 |
| Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Aripiprazole - Tourette's Disorder, Tic Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 110 | 2013-01-01 | 2015-10-16 |
| Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Aripiprazole, Placebo - Tourette's Disorder, Tic Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 133 | 2012-11-01 | 2015-02-13 |
| Proof-of-Concept Safety Study of CPP-109 (Vigabatrin) for Treatment Refractory Tourette's Disorder vigabatrin - Tourette's Disorder | Phase 1 / Phase 2 | Completed | Barbara J. Coffey | 4 | 2012-07-01 | 2018-01-19 |
| ABF Tourette's Disorder Post Marketing Surveillance Study Tourette's Disorder | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 692 | 2012-06-01 | 2019-04-01 | |
| Psychosocial Intervention for Young Children With Chronic Tics Comprehensive Behavioral Intervention for Tics (CBIT) - Tourette's Syndrome, Tourette's Disorder | Not applicable | Completed | Weill Medical College of Cornell University | 15 | 2012-01-20 | 2019-07-30 |
| Safety and Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Aripiprazole - Tourette's Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 170 | 2011-10-19 | 2021-10-07 |
| Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder (TD) Aripiprazole, Placebo - Tourette's Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 83 | 2011-08-02 | 2021-10-07 |
| Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Aripiprazole, Placebo - Tourette's Disorder | Phase 3 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 135 | 2011-07-27 | 2021-10-07 |
| Assessment of Children With Tic Onset in the Past 6 Months Tourette Syndrome, Tourette's Disorder | Completed | Washington University School of Medicine | 99 | 2010-08-01 | 2023-11-27 | |
| Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder aripiprazole, placebo - Chronic Motor or Vocal Tic Disorder, Tourette's Disorder | Phase 3 | Completed | Korea Otsuka Pharmaceutical Co., Ltd. | 61 | 2008-10-01 | 2013-07-26 |
| Internet-based Coaching for Young Adults With Neuropsychiatric Disorders Habilitation (Internet-based support and coaching) - Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder | Not applicable | Completed | Vardalinstitutet The Swedish Institute for Health Sciences | 12 | 2008-09-01 | 2014-12-12 |
| Omega-3 Fatty Acids in Tourette's Disorder Omega-3 Fatty Acids, Olive oil - Tourette's Disorder | Not applicable | Completed | NYU Langone Health | 33 | 2003-05-01 | 2014-07-01 |
Tourette Syndrome (18) · Tic Disorders (11) · Tics (8) · Bronchiolitis Obliterans Syndrome (3) · Attention Deficit Disorder with Hyperactivity (2) · Basal Ganglia Diseases (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Mental Disorders (2) · Movement Disorders (2) · Autism Spectrum Disorder (1) · Obsessive-Compulsive Disorder (1) · Sleep Initiation and Maintenance Disorders (1)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (18) · Genetic Diseases, Inborn (18) · Heredodegenerative Disorders, Nervous System (18) · Nervous System Diseases (18) · Neurodegenerative Diseases (18) · Neurodevelopmental Disorders (18) · Basal Ganglia Diseases (16) · Brain Diseases (16) · Central Nervous System Diseases (16) · Mental Disorders (16) · Movement Disorders (16) · Dyskinesias (8) · Neurologic Manifestations (8) · Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8)
Aripiprazole (6) · Fatty Acids, Omega-3 (1) · Hormone Replacement Therapy (1) · Olive Oil (1) · Palliative Care (1) · Rehabilitation (1) · Vigabatrin (1)
Otsuka Pharmaceutical Development & Commercialization, Inc. (5) · Karolinska Institutet (2) · Korea Otsuka Pharmaceutical Co., Ltd. (2) · University of California, Los Angeles (2) · Barbara J. Coffey (1) · Johns Hopkins University (1) · NYU Langone Health (1) · University of Utah (1) · Vardalinstitutet The Swedish Institute for Health Sciences (1) · Washington University School of Medicine (1) · Weill Medical College of Cornell University (1)
United States (12) · Canada (4) · Hungary (4) · South Korea (4) · Germany (3) · Mexico (3) · Romania (3) · Sweden (3) · Bulgaria (2) · Italy (2) · Taiwan (2) · Ukraine (2) · Spain (1)
Eva Kohegyi, MD (5) · Emily J Ricketts, PhD (2) · Barbara J Coffey, MD, MS (1) · David Mataix-Cols, PhD (1) · David Mataix-Cols, Professor (1) · Douglas W Woods, Ph.D. (1) · Elisabet Wentz, MD, PhD (1) · Hannah Reese, PhD (1) · Jonathan D Brodie, PhD,MD (1) · Joseph F McGuire, PhD (1) · Kevin J. Black, MD (1) · Michael B Himle, Ph.D. (1) · Shannon Bennett, PhD (1) · Soochurl Cho, MD. Ph.D (1) · Suzanne Mouton-Odum, Ph.D. (1)
PMID 22585765, PMID 24021518, PMID 27445874, PMID 28686474, PMID 30772854, PMID 34593015, PMID 35969401, PMID 38700867
K23MH113884 (1), K24MH087913 (1), R01AT012455 (1)