16 completed, 7 unknown, 4 not yet recruiting, 3 recruiting. 24 Not applicable, 2 Phase 4, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 24 | Completed 13, Not yet recruiting 4, Recruiting 3, Unknown 3, Withdrawn 1 |
| Phase 4 | 2 | Active not recruiting 1, Terminated 1 |
| Phase 1 | 1 | Unknown 1 |
| Phase 2 | 1 | Active not recruiting 1 |
Follow TMD: new trials by email Literature Review of TMD trials Research Report on TMD
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Vagus Nerve Stimulation on Temporomandibular Disorders. nVNS Treatment - TMD, Temporomandibular Disorders (TMDs) | Not applicable | Recruiting | Arpana Church | 10 | 2026-12-01 | 2026-11-06 |
| Efficacy and Safety of HA35 Gel Nighttime Occlusive Application for TMD Pain 10% High-Concentration 35 kDa Hyaluronan (HA35) Topical Gel - Temporomandibular Joint Disorders, TMD | Not applicable | Completed | Nakhia Impex LLC | 30 | 2026-05-20 | 2026-09-22 |
| Evaluation of the Effect of the Erchonia® EVRL on Chronic Jaw Pain Arising From TMJ Erchonia® EVRL™, Placebo Device - TMJ, TMJ Pain | Not applicable | Withdrawn | Erchonia Corporation | 2026-05-14 | 2026-09-23 | |
| Occlusal Splint Combined With Granisetron Injection for Management of Myofascial Pain Related to Temporomandibular Disorders Granisetron, lidocaine, occlusal splint - TMD, TMD/Orofacial Pain | Phase 4 | Active not recruiting | Mansoura University | 48 | 2026-01-27 | 2026-03-05 |
| Effects of Core Strengthening Exercises for Treating TMD Experimental: Group 1: Core Strengthening, Group 2: Standard TMD PT - Temporomandibular Joint Dysfunction, TMD | Not applicable | Not yet recruiting | Loyola University | 50 | 2025-11-01 | 2025-11-10 |
| Assessment of Injectable PRF Versus Dextrose Injection in Temporomandibular Joint in Anterior Disc Displacement With Reduction PRF treatment group, Dextrose 20% Prolotherapy - TMD | Phase 2 | Active not recruiting | Cairo University | 24 | 2025-10-10 | 2026-09-01 |
| Arthroscopic Anterior Release Versus Discectomy as Treatments for Temporomandibular Joint Disc Displacement With Reduction TMJ - Injury of Meniscus of Temporomandibular Joint, TMD | Enrolling by invitation | Karolinska Institutet | 65 | 2025-09-16 | 2025-12-30 | |
| ARS vs ARS With Arthrocentesis and PRP Injection in DDWR arthrocentesis - PRP injection -ARS, ARS - TMJ Disc Displacement With Reduction, TMD | Not applicable | Not yet recruiting | Cairo University | 20 | 2025-09-01 | 2025-08-11 |
| Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions Exercise, Manual therapy - TMD, TMD/Orofacial Pain | Not applicable | Recruiting | Tayfun ISIK | 48 | 2025-06-19 | 2025-12-26 |
| Conventional, Additive and Subtractive Occlusal Splints for TMDs Conventional Stabilizing Splint, Milled Stabilizing Splint, 3D Printed Stabilizing Splint - TMD, Disc Displacement | Not applicable | Completed | Mansoura University | 30 | 2025-02-01 | 2026-08-18 |
| Digital Occlusal Analysis and Enamel Wear Assessment in Temporomandibular Disorder Patients Treated with Fully Digital Versus Conventional Stabilization Splints stabilization splint - TMD, Temporomandibular Disorders (TMD) | Not applicable | Not yet recruiting | Minia University | 20 | 2025-01-26 | 2025-01-17 |
| Exploring the Relationship Between Occlusion and Degenerative TMJ Disorders: A Comparative Clinical Study Occlusal Splint and Bite Correction Therapy, Conventional TMJ Therapy, Routine TMJ Care (Medication Only) - Degenerative Joint Disease, TMD | Not applicable | Completed | King Khalid University | 150 | 2025-01-10 | 2025-05-07 |
| Two Treatment Modalities for Myogenous Temporomandibular Disorders Stabilization Appliance, Ear Stent - TMD | Not applicable | Recruiting | Alexandria University | 32 | 2025-01-01 | 2026-01-20 |
| AMOUNT OF INTRAORAL OCCLUSAL ADJUSTMENTS IN OCCLUSAL SPLINTS FABRICATED USING FULLY DIGITAL VERSUS COMBINED DIGITAL WORKFLOW IN TMD PATIENTS Occlusal splints fabricated using a fully digital workflow including the use of a jaw tracking device., Occlusal splints fabricated using a combined digital workflow using a conventional bite technique - TMD | Not applicable | Not yet recruiting | Cairo University | 26 | 2025-01-01 | 2024-12-30 |
| Impact of Breather Device on Ventilatory Effort in Patient With MTMD the breather device, conventional exercise program - TMD | Not applicable | Unknown | Cairo University | 60 | 2024-09-01 | 2024-08-23 |
| Is PNF Application Effective on Temporomandibular Dysfunction Rocabado's 6x6 Exercises, PNF Exercises - TMD, TMJ Disorder | Not applicable | Completed | Istanbul Medipol University Hospital | 40 | 2023-09-05 | 2025-02-20 |
| Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain Diagnostic Criteria for Temporomandibular Disorders Clinical Examination, Blood test - TMD, Masticatory Muscle Pain | Enrolling by invitation | Wroclaw Medical University | 102 | 2023-09-01 | 2026-02-03 | |
| Laser Therapy and Temporomandibular Disorders Nd YAG laser, diode laser (980 nm), diode laser (940 nm) - TMD | Not applicable | Unknown | Hams Hamed Abdelrahman | 50 | 2022-11-30 | 2022-12-14 |
| Accuracy of Patient Specific Guide for TMJ Injection TMJ injection using patient specific guide - TMD | Not applicable | Completed | Al-Azhar University | 5 | 2022-04-19 | 2022-08-30 |
| Treatment Outcomes in Patients With Muscular Temporo-mandibular Joint Disorders Questionnaires administered to all study participants - TMD, TMD/Orofacial Pain | Completed | University of Pisa | 120 | 2022-01-10 | 2025-04-03 |
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Temporomandibular Joint Disorders (11) · Facial Pain (3) · Agnosia (2) · Bruxism (2) · Chronic Pain (1) · Joint Diseases (1) · Motor Activity (1) · Myofascial Pain Syndromes (1) · Pain (1) · Patient Satisfaction (1) · Sleep Bruxism (1) · Sleep Wake Disorders (1)
Stomatognathic Diseases (13) · Musculoskeletal Diseases (12) · Craniomandibular Disorders (11) · Jaw Diseases (11) · Joint Diseases (11) · Mandibular Diseases (11) · Muscular Diseases (11) · Neurologic Manifestations (7) · Pathological Conditions, Signs and Symptoms (7) · Signs and Symptoms (7) · Behavior (4) · Pain (4) · Nervous System Diseases (3) · Tooth Diseases (3) · Habits (2)
Occlusal Splints (4) · Exercise (2) · Cannabinoids (1) · Counseling (1) · Electromyography (1) · Glucose (1) · Granisetron (1) · Hematologic Tests (1) · Lasers, Semiconductor (1) · Lasers, Solid-State (1) · Lidocaine (1) · Low-Level Light Therapy (1) · Muscle Stretching Exercises (1) · Musculoskeletal Manipulations (1) · Naproxen (1)
Cairo University (6) · Al-Azhar University (2) · Mansoura University (2) · Pomeranian Medical University Szczecin (2) · Alexandria University (1) · Arpana Church (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Erchonia Corporation (1) · Hams Hamed Abdelrahman (1) · Istanbul Medipol University Hospital (1) · Istanbul University (1) · Karolinska Institutet (1) · King Khalid University (1) · Loyola University (1) · Minia University (1)
Egypt (9) · United States (5) · Turkey (Türkiye) (4) · Canada (2) · Italy (2) · Poland (2) · Argentina (1) · Australia (1) · China (1) · Germany (1) · Iran (1) · Saudi Arabia (1) · Sweden (1)
AbdElKader A Hyder, MSc (2) · Bahaa El-Din A Tawfik, PhD (2) · Wael A ElMohandes, PhD (2) · Amr Nagib, PhD (1) · Arpana Church, Ph.D. (1) · Azza Hussein, PhD (1) · Bilge Gokcen Rohlig, Prof. Dr. (1) · David A Seminowicz, PhD (1) · Dr. Allan Gordon, PhD (1) · Edward S Kijak, DSc (1) · Gilles Lavigne (1) · Gizem Ergezen, PhD (1) · Gwendolyn Reeve, DMD FACS (1) · Iman Radi, PhD (1)
PMID 25050363, PMID 31198477, PMID 32766469
2025 (1)