96 completed, 40 unknown, 23 terminated, 22 recruiting. 31 Phase 2, 29 Phase 3, 23 Not applicable, 9 Phase 4, 5 Phase 1.
Follow Thrombophilia: new trials by email Literature Review of Thrombophilia trials Research Report on Thrombophilia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safflower (Carthamus Tinctorius L.) Granules for Sepsis-associated Coagulopathy High-dose safflower granules, Medium-dose safflower granules, Placebo granules (one-tenth of medium-dose safflower) - Sepsis, Disseminated Intravascular Coagulation (DIC) | Not applicable | Not yet recruiting | Shanghai Jiao Tong University School of Medicine | 210 | 2026-11-01 | 2026-10-27 |
| A Study to Learn More About the Treatment of People With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Who Received Recombinant ADAMTS13 (rADAMTS13) as Part of the Early Access Program No Intervention - Thrombotic Thrombocytopenic Purpura (TTP) | Recruiting | Takeda | 94 | 2026-09-24 | 2026-10-20 | |
| EARLY DIAGNOSIS OF SEPTIC DIC Disseminated Intravascular Coagulation (DIC), Reanimation | Not yet recruiting | University Hospital, Strasbourg, France | 492 | 2026-06-15 | 2026-06-05 | |
| The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity Aspirin, Low-molecular-weight heparin - Venous Thromboembolism, Postpartum Period | Phase 3 | Recruiting | University of Calgary | 8805 | 2026-06-04 | 2026-07-27 |
| A Study in Children and, Adults With Congenital Thrombotic Thrombocytopenic Purpura (cTTP) Treated With Adzynma No Intervention - Thrombotic Thrombocytopenic Purpura (TTP) | Recruiting | Takeda | 50 | 2026-05-26 | 2026-10-02 | |
| Fluorescent Leukocytes as a Marker of Early Sepsis/Severity Sepsis, Disseminated Intravascular Coagulation (DIC) | Not yet recruiting | University Hospital, Strasbourg, France | 492 | 2026-05-12 | 2026-05-14 | |
| MICROVASCULAR DAMAGE IN THROMBOTIC THROMBOCYTOPENIC PURPURA Factor VIII (FVIII), Von Willebrand factor (VWF) antigen, VWF:RCo - TTP - Thrombotic Thrombocytopenic Purpura | Not applicable | Active not recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 79 | 2026-02-28 | 2026-06-09 |
| Evaluation of a Preventive Therapeutic Strategy for Postpartum Venous Thromboembolism in Women With Genetic Risk Factor Retrospective collection of health data, Phone call to every participant - Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation | Completed | Hospices Civils de Lyon | 86 | 2026-02-04 | 2026-04-06 | |
| Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects Saccharin, Sucralose, Erythritol - Prediabetic State, Metabolic Syndrome | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 80 | 2026-01-05 | 2026-01-29 |
| Role of Fibrinolytic Activity in Neoplastic Pathologies Complicated by Coagulopathy An additional volume of blood will be drawn as part of routine follow-up care - Hematologic Neoplasms, Solid Tumor Metastatic Cancer Advanced Cancer | Not yet recruiting | University Hospital, Strasbourg, France | 150 | 2026-01-01 | 2025-12-10 | |
| Observational Study to Evaluate the Effectiveness of DOACS for Secondary Thrombosis Prevention in Low-risk Thrombotic APS Patients Antiphospholipid Syndrome (APS), Venous Thrombosis (Disorder) | Recruiting | Infanta Leonor University Hospital | 600 | 2025-12-01 | 2026-01-30 | |
| Daratumumab in Immune-mediated Thrombotic Thrombocytopenic Purpura Thrombotic Thrombocytopenic Purpura, Acquired | Recruiting | Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico | 40 | 2025-10-01 | 2026-04-14 | |
| A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers. BAY 3389934, Matching Placebo / Diluent - Sepsis Associated Disseminated Intravascular Coagulation (DIC) | Phase 1 | Completed | Bayer | 16 | 2025-09-22 | 2026-06-05 |
| Effects of Lumbrokinase DLBS1033 on D-Dimer, Interleukin-6, and Clinical Outcomes in Patients With Pneumonia and Sepsis Placebo Tablet(s), DLBS1033 - Pneumonia, Sepsis | Phase 2 | Completed | Universitas Sebelas Maret | 50 | 2025-08-14 | 2026-10-23 |
| Hematological Disorders in EHPVO Patients No intervention (Observational Study) - Extrahepatic Portal Vein Obstruction (EHPVO), Thrombophilia | Not yet recruiting | Rahab Nady | 115 | 2025-08-01 | 2025-08-06 | |
| Belgian Antithrombin Deficiency Registry observation - Antithrombin III Deficiency | Not yet recruiting | Universitair Ziekenhuis Brussel | 1000 | 2025-05-01 | 2024-12-04 | |
| A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy BAY3389934 - Sepsis, Coagulopathy | Phase 1 | Recruiting | Bayer | 36 | 2025-03-12 | 2026-10-16 |
| Construction of a Multi-dimensional Risk Assessment System: a Clinical Study of Polycystic Ovary Syndrome Complicated With Thrombophilia Polycystic Ovary Syndrome (PCOS), Thrombophilia | Recruiting | Guangdong Women and Children Hospital | 100 | 2025-03-04 | 2026-07-30 | |
| An Observational Study in the United States to Learn How Venous Thromboembolism, Disseminated Intravascular Coagulation, and Sepsis Are Related Diagnosis of both VTE and sepsis - Sepsis, Venous Thromboembolism | Active not recruiting | Bayer | 10000 | 2025-01-06 | 2026-10-19 | |
| Predictive Value of Scoring System in Neonates with Disseminated Intravascular Coagulation Disseminated Intravascular Coagulation, Neonates | Not yet recruiting | Assiut University | 43 | 2025-01-01 | 2024-10-04 |
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Purpura, Thrombotic Thrombocytopenic (65) · Disseminated Intravascular Coagulation (41) · Thrombosis (20) · Venous Thrombosis (16) · COVID-19 (15) · Sepsis (15) · Hemostatic Disorders (13) · Venous Thromboembolism (11) · Antithrombin III Deficiency (10) · Pulmonary Embolism (9) · Shock, Septic (8) · Thrombocytopenia (8) · Antiphospholipid Syndrome (7) · Pre-Eclampsia (7)
Hemic and Lymphatic Diseases (207) · Hematologic Diseases (202) · Blood Coagulation Disorders (122) · Pathological Conditions, Signs and Symptoms (111) · Pathologic Processes (107) · Hemorrhage (68) · Signs and Symptoms (68) · Cytopenia (67) · Blood Platelet Disorders (65) · Purpura (65) · Skin Manifestations (65) · Purpura, Thrombocytopenic (64) · Cardiovascular Diseases (59) · Thrombocytopenia (59)
Rituximab (9) · Aspirin (8) · caplacizumab (8) · Plasma Exchange (6) · Dalteparin (5) · Enoxaparin (5) · Blood Specimen Collection (4) · Standard of Care (4) · ADAMTS13 protein, human (3) · Adrenal Cortex Hormones (3) · Heparin, Low-Molecular-Weight (3) · Observation (3) · Protein C (3) · ARC 1779 (2) · ART123 (2)
Assistance Publique - Hôpitaux de Paris (7) · Takeda (7) · Baxalta now part of Shire (5) · University Hospital, Strasbourg, France (5) · Bayer (4) · HaEmek Medical Center, Israel (4) · Kyowa Kirin Co., Ltd. (4) · Octapharma (4) · Assiut University (3) · Peking University People's Hospital (3) · Sanofi (3) · University College, London (3) · Ablynx, a Sanofi company (2) · Archemix Corp. (2) · Central Hospital, Nancy, France (2)
United States (50) · France (39) · Italy (22) · United Kingdom (22) · Germany (20) · Canada (17) · China (16) · Austria (15) · Spain (14) · Japan (13) · Belgium (9) · Israel (9) · Netherlands (9) · Turkey (Türkiye) (7) · Australia (6)
Ariel Koren, MD (2) · Leslie Skeith, MD (2) · Marc Rodger, MD (2) · Abimbola Aina, MD (1) · Adrian Covic, Professor (1) · Alex James Butwick (1)
PMID 33779986, PMID 22449204, PMID 24335249, PMID 32358837, PMID 33881463, PMID 35244208, PMID 11057854, PMID 12353309, PMID 14719181, PMID 1538192, PMID 15389904, PMID 15500369, PMID 15577929, PMID 16375711, PMID 16439370, PMID 17164349, PMID 17636190, PMID 17804043, PMID 17849048, PMID 17997389, PMID 18226126, PMID 18277138, PMID 18295303, PMID 18363820, PMID 18449420, PMID 18574602, PMID 18766260, PMID 18782260, PMID 19620844, PMID 19806251, PMID 20058208, PMID 20735725, PMID 21636861, PMID 21859903, PMID 21913128, PMID 21982959, PMID 22475545, PMID 22540524, PMID 22547583, PMID 22676992, PMID 23279219, PMID 2329037, PMID 23470153, PMID 23616916, PMID 23715103, PMID 23823859, PMID 23846249, PMID 23915256, PMID 24146249, PMID 24154514
2016 (2), 2015 (1), 2017 (1), 2018 (1), 2019 (1), 2023 (1), U01HL072268 (1), U54HL112303 (1)