7 completed, 5 terminated, 2 unknown. 6 Phase 2, 3 Phase 3, 1 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 3, Terminated 3 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Protein C: new trials by email Literature Review of Protein C trials Research Report on Protein C
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who Completed a Sponsored SerpinPC Clinical Trial SerpinPC - Hemophilia a, Hemophilia B | Phase 3 | Terminated | ApcinteX Ltd | 15 | 2024-07-11 | 2025-02-10 |
| Thrombophilia In Beta Thalassemia PT, Protein C, Platelet aggregation by ADP and arachidonic acid - Beta-Thalassemia | Unknown | Assiut University | 100 | 2024-05-07 | 2024-05-07 | |
| A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitors SerpinPC - Hemophilia B with Inhibitor, Hemophilia B | Phase 2 | Terminated | ApcinteX Ltd | 3 | 2023-07-28 | 2025-03-11 |
| The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B SerpinPC - Hemophilia a, Hemophilia B | Phase 2 | Terminated | ApcinteX Ltd | 60 | 2023-07-06 | 2025-03-11 |
| Assessment of Antithrombin III, Protein C, Protein S and D-dimer in Acute Leukemia Antithrombin III, Protein C, Protein S - Acute Leukemia | Completed | Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy | 90 | 2023-06-01 | 2026-01-29 | |
| A Study of TAK-662 for Japanese Patients With Congenital Protein C Deficiency TAK-662 - Congenital Protein C Deficiency | Phase 1 / Phase 2 | Completed | Takeda | 5 | 2021-09-07 | 2025-05-07 |
| Haemostatic Imbalance in Patients With Chronic Liver Disease Laboratory investigations ( protein C, protein S , antithrombin III) - Haemostasis Imbalance in Chronic Liver Disease | Unknown | Assiut University | 100 | 2018-09-01 | 2018-07-18 | |
| Administration of Protein C Concentrates in Adult Critically Ill Septic Patients Protein C concentrate - Sepsis | Phase 3 | Terminated | Università Vita-Salute San Raffaele | 2012-09-01 | 2015-12-15 | |
| Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock. Human protein C concentrate, Activated protein C, Placebo comparator - Sepsis, Septic Shock | Phase 2 | Completed | University of Roma La Sapienza | 60 | 2011-01-01 | 2015-12-02 |
| Ceprotin Treatment Registry Protein C Concentrate (Human) - Protein C Deficiency | Completed | Baxalta now part of Shire | 43 | 2010-06-23 | 2021-03-17 | |
| Activated Protein C in Acute Stroke Trial Activated Protein C - Stroke | Phase 2 | Terminated | University of Rochester | 12 | 2007-09-01 | 2016-10-24 |
| Retrospective Study to Capture Dosing and Treatment Outcome Data in Participants With Severe Congenital Protein C Deficiency Who Were Treated With Protein C Concentrate Under an Emergency Use IND Protein C Concentrate (Human) Vapor Heated - Protein C Deficiency | Completed | Baxalta now part of Shire | 11 | 2005-06-01 | 2021-04-08 | |
| Efficacy and Safety Study of Protein C Concentrate in Subjects With Severe Congenital Protein C Deficiency Protein C Concentrate (Human) Vapor Heated - Protein C Deficiency | Phase 2 / Phase 3 | Completed | Baxalta now part of Shire | 18 | 2003-08-22 | 2021-05-05 |
| Activated Protein C in Severe Acute Pancreatitis Activated protein C - Acute Pancreatitis | Phase 4 | Completed | Helsinki University Central Hospital | 32 | 2003-06-01 | 2010-10-14 |
Hemophilia A (3) · Hemophilia B (3) · Protein C Deficiency (3) · Sepsis (2) · Ischemic Stroke (1) · Pancreatitis (1) · Shock, Septic (1) · Stroke (1) · beta-Thalassemia (1)
ApcinteX Ltd (3) · Baxalta now part of Shire (3) · Assiut University (2) · Helsinki University Central Hospital (1) · Muhamed Ahmed Abdelmoaty Muhamed Alhagrasy (1) · Takeda (1) · University of Rochester (1) · University of Roma La Sapienza (1) · Università Vita-Salute San Raffaele (1)
United States (6) · Italy (5) · Germany (3) · United Kingdom (3) · Armenia (2) · Australia (2) · France (2) · India (2) · Spain (2) · Taiwan (2) · Turkey (Türkiye) (2) · Austria (1) · Belgium (1) · Canada (1) · Egypt (1)
Andrea Morelli, MD (1) · Curtis Benesch, MD, MPH (1)
PMID 20663207, PMID 41859023, PMID 42745610
2023 (1), R01HL080107 (1)