29 completed, 6 terminated, 5 not yet recruiting, 5 recruiting. 51 Phase 2, 9 Phase 3, 2 Phase 1.
Follow Thinness: new trials by email Literature Review of Thinness trials Research Report on Thinness
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II Clinical Study Evaluating the Efficacy and Safety of SXRN Injection in Patients With Cancer Cachexia SXRN Injection, Placebo - Cachexia-Anorexia Syndrome, Cachexia; Cancer | Phase 2 | Not yet recruiting | Jiangsu Guiqiong Pharmaceutical Co., Ltd. | 96 | 2026-12-01 | 2026-10-26 |
| Master Protocol for the Study of Rilogrotug for the Treatment of Weight Loss and Anorexia in Patients With Cancer Cachexia and mCRC or mNSCLC Rilogrotug, Placebo - Cachexia; Cancer, Cachexia | Phase 2 / Phase 3 | Not yet recruiting | AVEO Pharmaceuticals, Inc. | 950 | 2026-11-01 | 2026-10-28 |
| Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and Immunotherapy Nanocrystalline megestrol acetate, Placebo - Hepatocellular Carcinoma (HCC), Cachexia | Phase 2 | Not yet recruiting | Nanfang Hospital, Southern Medical University | 88 | 2026-06-22 | 2026-05-04 |
| Phase 2 Cachexia Clinical Trial to Evaluate the Efficacy and Safety of ASCA101 Active Comparator, ASCA101 24.32mg/kg, ASCA101 32.43mg/kg - Cachexia; Cancer | Phase 2 | Recruiting | MetaFines | 135 | 2026-05-08 | 2026-06-17 |
| Intestinal Microbiota Transplantation for Treating Advanced Tumor Cachexia FMT capsule - Cachexia; Cancer, Fecal Microbiota Transplantation (FMT) | Phase 2 | Not yet recruiting | Hua Jiang | 66 | 2026-05-01 | 2026-04-16 |
| Study of the Safety and Efficacy of DS010 in Patients With Cancer Cachexia DS010 injection - Cancer, Cachexia | Phase 1 / Phase 2 | Not yet recruiting | Dartsbio Pharmaceuticals Ltd. | 58 | 2026-04-30 | 2026-04-15 |
| Visugromab in Cachexia International Trial Visugromab (CTL-002), Placebo - Cancer-associated Cachexia | Phase 2 / Phase 3 | Recruiting | CatalYm GmbH | 518 | 2026-04-16 | 2026-09-22 |
| A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue ponsegromab, placebo - Cachexia, Metastatic Pancreatic Ductal Adenocarcinoma | Phase 2 / Phase 3 | Recruiting | Pfizer | 982 | 2025-10-03 | 2026-10-14 |
| Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy TCMCB07, Placebo - Cancer Weight Loss | Phase 2 | Recruiting | Endevica Bio | 120 | 2025-04-28 | 2026-07-15 |
| Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer Olanzapine, Placebo Administration, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 66 | 2024-07-17 | 2026-07-16 |
| Anamorelin Study for Advanced Pancreatic Cancer Anamorelin Hydrochloride, Placebo - Metastatic Pancreatic Cancer | Phase 2 | Terminated | Lahey Clinic | 4 | 2023-04-01 | 2025-11-17 |
| Study of the Efficacy and Safety of Ponsegromab in Patients With Cancer, Cachexia and Elevated GDF-15 ponsegromab, Placebo for ponsegromab - Non-small Cell Lung Cancer, Pancreatic Cancer | Phase 2 | Completed | Pfizer | 187 | 2022-11-21 | 2026-06-03 |
| ComPAS Low-WAZ RCT Mali Simplified dose of ready-to-use therapeutic food (RUTF), Standard dose of ready-to-use therapeutic food (RUTF), No nutritional treatment - Acute Malnutrition in Infancy, Acute Malnutrition in Childhood | Phase 2 / Phase 3 | Unknown | International Rescue Committee | 1500 | 2022-09-01 | 2024-01-03 |
| Mirtazapine Versus Megestrol Acetate in Treatment of Anorexia-cachexia in Advanced Cancer Patients. Mirtazapine, Megestrol Acetate - Anorexia | Phase 2 | Unknown | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 80 | 2022-06-01 | 2022-05-18 |
| Effect of Multi-modal Intervention Care on Cachexia in Patients With Advanced Cancer Compared to Conventional Management (MIRACLE) Multi-modal intervention - Gastric Cancer, Colorectal Cancer | Phase 2 | Unknown | Kil Yeon Lee | 112 | 2020-01-31 | 2021-06-01 |
| Comparison Between Mirtazapine and Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care. Mirtazapine, Megestrol - Cachexia; Cancer, Anorexia | Phase 2 | Completed | University of Sao Paulo | 52 | 2019-03-26 | 2023-07-07 |
| Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD) GSK2881078, Matching Placebo - Cachexia | Phase 2 | Completed | GlaxoSmithKline | 97 | 2018-02-28 | 2020-07-15 |
| The Effect of Cannabis in Pancreatic Cancer THC and CBD Mixture - Neoplasms Pancreatic, Cachexia; Cancer | Phase 2 | Withdrawn | Jens Rikardt Andersen | 2017-10-06 | 2023-12-18 | |
| Is Clarithromycin a Potential Treatment for Cachexia in People With Lung Cancer? Clarithromycin, Placebo - Cachexia, Lung Cancer | Phase 2 | Terminated | University of Nottingham | 1 | 2015-04-01 | 2016-09-16 |
| Reformulated F75 Milk to Treat Severe Acute Malnutrition Standard F75 Milk, Modified F75 Milk - Malnutrition, Diarrhoea | Phase 2 / Phase 3 | Completed | University of Oxford | 842 | 2014-12-01 | 2016-04-14 |
Showing 20 of 51. Sign in to see all of them.
Cachexia (51) · Anorexia (19) · Neoplasms (16) · Weight Loss (10) · Pancreatic Neoplasms (8) · Colorectal Neoplasms (6) · Carcinoma, Non-Small-Cell Lung (5) · Fatigue (4) · HIV Infections (4) · Lung Neoplasms (4) · Malnutrition (4) · Pulmonary Disease, Chronic Obstructive (4) · Acquired Immunodeficiency Syndrome (3) · Emaciation (2) · Growth Disorders (2)
Pathological Conditions, Signs and Symptoms (51) · Signs and Symptoms (51) · Body Weight (50) · Body Weight Changes (50) · Weight Loss (41) · Signs and Symptoms, Digestive (20) · Neoplasms by Site (17) · Respiratory Tract Diseases (14) · Lung Diseases (13) · Digestive System Diseases (12) · Digestive System Neoplasms (12) · Neoplasms (11) · Pathologic Processes (9) · Respiratory Tract Neoplasms (9)
Megestrol Acetate (6) · Infliximab (2) · Mirtazapine (2) · Olanzapine (2) · bimagrumab (2) · Clarithromycin (1) · Cyproheptadine (1) · Etanercept (1) · Fecal Microbiota Transplantation (1) · Flurandrenolone (1) · GSK2881078 (1) · Gemcitabine (1) · Ghrelin (1) · Ibuprofen (1) · Megestrol (1)
Novartis Pharmaceuticals (4) · Pfizer (2) · AVEO Pharmaceuticals, Inc. (1) · Acacia Pharma Ltd (1) · Akamis Bio (1) · Anaborex (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Bristol-Myers Squibb (1) · CSL Behring (1) · Cantonal Hospital of St. Gallen (1) · CatalYm GmbH (1) · Celgene Corporation (1) · Center for Integrated Rehabilitation and Organ Failure Horn (1) · Centocor, Inc. (1) · Centre for Food and Nutrition Research, Yaounde (1)
United States (23) · United Kingdom (7) · Canada (6) · China (6) · Germany (6) · India (6) · Poland (5) · Romania (4) · Australia (3) · Bangladesh (3) · Bulgaria (3) · South Korea (3) · Spain (3) · Switzerland (3) · Taiwan (3)
Abu Ahmed Shamim, MS (1) · Alain B Labrique, PhD (1) · Alexander Ginting (1) · Andrew Wilcock (1) · Biswa Mohan Biswal (1) · Britta Schumacher, PhD (1) · Chang-yao Tsao (1) · Cheng-ta Yang (1) · Chung-kong Kwan (1) · Dae-ho Lee (1)
PMID 11786587, PMID 12457271, PMID 12648025, PMID 15778874, PMID 15857739, PMID 16317825, PMID 16376734, PMID 16408219, PMID 1666930, PMID 16849753, PMID 17566383, PMID 17589370, PMID 17662149, PMID 18257397, PMID 18402303, PMID 18728826, PMID 18989154, PMID 19587829, PMID 19883531, PMID 19896326, PMID 20076976, PMID 21343383, PMID 21475692, PMID 22076835, PMID 23141881, PMID 23499390, PMID 25524795, PMID 26883879, PMID 27252077, PMID 27403414, PMID 27680994, PMID 28644348, PMID 29550881, PMID 30095981, PMID 30184222, PMID 30807589, PMID 31037340, PMID 31775877, PMID 32240304, PMID 32875267, PMID 33154417, PMID 34538239, PMID 35410294, PMID 36283827, PMID 3774823, PMID 38191436, PMID 38500292, PMID 38641716, PMID 39007915, PMID 39282907
2017 (1), 2023 (1), 2025 (1), P30CA069533 (1), U10CA081920 (1)