4 completed, 4 unknown, 1 terminated, 1 withdrawn. 10 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 4, Unknown 4, Terminated 1, Withdrawn 1 |
Follow Stevens-Johnson Syndrome: new trials by email Literature Review of Stevens-Johnson Syndrome trials Research Report on Stevens-Johnson Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study To Evaluate The Efficacy Of Tofacitinib In Patients With SJS/TEN Tofacitinib - Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis | Not applicable | Completed | Chang Gung Memorial Hospital | 20 | 2022-08-01 | 2025-09-16 |
| Meibomian Gland Probing in the Sub-Acute Phase of Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Maskin Probe - Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses | Not applicable | Unknown | Massachusetts Eye and Ear Infirmary | 30 | 2021-12-01 | 2021-12-06 |
| Evaluation of Tangible Boost for Patients With Stevens Johnson Syndrome, Sjogren's Syndrome, and Graft Vs Host Disease Tangible Boost, Placebo - Stevens-Johnson Syndrome, Graft Versus Host Disease in Eye | Not applicable | Terminated | Tangible Science | 28 | 2020-02-24 | 2026-10-28 |
| HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions HLA screening before commencing aromatic AEDs - Epilepsy, Neuropathy | Not applicable | Unknown | Second Affiliated Hospital of Guangzhou Medical University | 4000 | 2017-08-01 | 2018-09-05 |
| Evaluating the Effect of Isotretinoin in Regulatory T-cell Function in Adverse Cutaneous Drug Eruptions (ACDEs): A Pilot Study Isotretinoin, Placebo - Toxic Epidermal Necrolysis | Not applicable | Withdrawn | Massachusetts General Hospital | 2016-11-01 | 2023-06-07 | |
| Minor Salivary Gland Transplantation for Cicatrizing Conjunctivitis minor salivary gland transplantation - Cicatrizing Conjunctivitis, Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum | Not applicable | Unknown | National Taiwan University Hospital | 30 | 2016-09-01 | 2019-02-15 |
| HLA-B*5801 Screening to Prevent Allopurinol-induced Severe Cutaneous Adverse Reaction HLA-B*5801 test - Stevens-Johnson Syndrome, Kidney Failure, Chronic | Not applicable | Unknown | Seoul National University Hospital | 600 | 2016-02-24 | 2017-02-08 |
| Safety and Performance Study of the ARGOS-IO System in Patients Undergoing Boston Keratoprosthesis Implantation ARGOS-IO system - Graft vs Host Disease, Congenital Aniridia | Not applicable | Completed | Implandata Ophthalmic Products GmbH | 13 | 2015-03-01 | 2025-02-27 |
| Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome. Salivary Gland and Labial Mucous Membrane Transplantation - Symblepharon, Dry Eye | Not applicable | Completed | Federal University of São Paulo | 19 | 2008-12-01 | 2016-08-11 |
| Cultivated Stem Cell Transplantation for the Treatment of Limbal Stem Cell Deficiency Cultivated limbal stem cell graft transplantation - Limbal Stem Cell Deficiency | Not applicable | Completed | Veerle Van Gerwen | 21 | 2008-07-01 | 2026-06-18 |
Dry Eye Syndromes (3) · Aniridia (2) · Sjogren's Syndrome (2) · Blepharospasm (1) · Bronchiolitis Obliterans Syndrome (1) · Burns, Chemical (1) · Epilepsy (1) · Graft vs Host Disease (1) · Hydrophthalmos (1) · Kidney Failure, Chronic (1) · Limbal Stem Cell Deficiency (1) · Meibomian Gland Dysfunction (1) · Meibomitis (1) · Mental Disorders (1)
Chemically-Induced Disorders (10) · Dermatitis (10) · Drug Eruptions (10) · Drug Hypersensitivity (10) · Drug-Related Side Effects and Adverse Reactions (10) · Erythema (10) · Erythema Multiforme (10) · Hypersensitivity (10) · Hypersensitivity, Delayed (10) · Immune System Diseases (10) · Mouth Diseases (10) · Skin Diseases (10) · Skin Diseases, Vesiculobullous (10) · Skin and Connective Tissue Diseases (10) · Stomatitis (10)
Isotretinoin (1) · tofacitinib (1)
Chang Gung Memorial Hospital (1) · Federal University of São Paulo (1) · Implandata Ophthalmic Products GmbH (1) · Massachusetts Eye and Ear Infirmary (1) · Massachusetts General Hospital (1) · National Taiwan University Hospital (1) · Second Affiliated Hospital of Guangzhou Medical University (1) · Seoul National University Hospital (1) · Tangible Science (1) · Veerle Van Gerwen (1)
United States (3) · Taiwan (2) · Belgium (1) · Brazil (1) · China (1) · Germany (1) · South Korea (1)
Arturo Saavedra, MD, PhD (1) · Carina Koppen, MD, PhD (1) · Chun Bing Chen (1) · Hsiao-Sang Chu, MD, MS (1) · Karen Carrasquillo, OD, PhD (1) · Marie J Tassignon, MD, PhD (1) · Nadia Zakaria, MBBS, PhD (1) · Thomas Neuhann, Prof. MD (1) · Wei-Ping Liao, M.D.,Ph.D. (1) · Zwi Berneman, MD,PhD (1)